Artery Research
Volume 16, Issue C, December 2016
Research Article
1. Experimental verification of the healthy and atherosclerotic coronary arteries incompressibility via Digital Image Correlation
Alireza Karimi, Toshihiro Sera, Susumu Kudo, Mahdi Navidbakhsh
Pages: 1 - 7
So far there is no study to measure the Poisson’s ratio of the human coronary arteries in order to verify their incompressibility regardless of being healthy or atherosclerosis. It has been reported that atherosclerosis alters the elastin content of the arterial wall which is responsible for the elastic...
Case Report
2. A case report: How a failure of reversal in arterial flow during development lead to the hypoplasia of a posterior cerebral artery and a resulting incomplete Circle of Willis
Timothy Patterson, Matthew O’Donnell, Samantha Taylor, Sarah Patterson
Pages: 8 - 10
Research Article
3. Concomitance of atherosclerotic lesions in arteries of the lower extremities and carotid arteries in patients with abdominal aorta aneurysm
Piotr Kaźmierski, Michał Pająk, Katarzyna Bogusiak
Pages: 11 - 17
Atherosclerosis was considered the main cause of abdominal aorta aneurysms. Many researchers suggest the presence of the association between these two entities. The aim of this paper was to evaluate the presence of atherosclerosis in the aorta and the arteries of the lower extremities, as well as stenoses...
Research Article
4. Estimates of arterial stiffness and central blood pressure in patients with type 2 diabetes: A comparison of SphygmoCor and Arteriograph
Christoffer Krogager, Niklas B. Rossen, Klavs W. Hansen, Søren T. Knudsen, Christian D. Peters, Hans Erik Bøtker, Per L. Poulsen, Esben Laugesen
Pages: 18 - 24
Background: The Arteriograph is a cuff-based oscillometric device for non-invasive assessment of central systolic blood pressure (cSBP), aortic augmentation index (Aix) and aortic pulse wave velocity (PWV). Reproducibility of Arteriograph measurements and the agreement with SphygmoCor in diabetic patients...
Review Article
5. Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen
Siana Jones, Scott T. Chiesa, Nishi Chaturvedi, Alun D. Hughes
Pages: 25 - 33
Purpose of review: Continuous wave near infrared spectroscopy (CW NIRS) provides non-invasive technology to measure relative changes in oxy- and deoxy-haemoglobin in a dynamic environment. This allows determination of local skeletal muscle O2 saturation, muscle oxygen consumption (
V˙O2
) and blood...
Research Article
6. Antiretroviral treatment and time since HIV-1 diagnosis are associated with large artery stiffness in sub-Saharan African HIV-1 patients
Titus F. Msoka, Gary P. Van Guilder, Yvo M. Smulders, Marceline van Furth, John A. Bartlett, Michiel A. van Agtmael
Pages: 34 - 41
Background: HIV-1 infection in northern populations is associated with increased large artery stiffness, both in the absence and presence of combination antiretroviral treatment (cART). It is unclear if similar changes occur in sub-Sahara African HIV-infected persons. The study aimed to determine whether...
Short Communication
7. Aggressive renal sympathetic denervation approach to treating resistant hypertension: A fresh start?
Márcio Galindo Kiuchi, Luis Marcelo Rodrigues Paz, Shaojie Chen
Pages: 42 - 44
A multivariable analysis identified predictors of systolic blood pressure change in SYMPLICITY HTN-3 trial. Additional analyses examined the influence of medication changes, results in selected subgroups and procedural factors. Greater reductions in office and ambulatory systolic blood pressure, and...
Conference Abstract
8. REMODELLING SMALL ARTERIES AND PHD TRAINING: A JOURNEY
Michael J. Mulvany
Pages: 45 - 45
Biomedical research is increasingly based on the efforts of PhD students. This talk will trace the development of the author’s research, and show how this experience can be used to optimize PhD training. The basis of the research has been that essential hypertension is associated with increased peripheral...
Conference Abstract
9. STEM CELL THERAPY FOR CARDIOVASCULAR DISEASES
Jean Sebastien Silvestre
Pages: 45 - 45
Stem cell-based therapies for vascular regeneration in patients with cardiovascular ischemic diseases initially relied on a very simple concept: therapeutic stem/progenitor cells might differentiate into vascular cells, mainly of endothelial phenotype, increasing new vessel formation and tissue perfusion...
Conference Abstract
10. ARTERIAL PROTEOMICS: LESSONS IN RELATION TO STIFFNESS, ANEURYSMS, DIABETES AND OTHER CONDITIONS
Lars Melholt Rasmussen
Pages: 45 - 45
Proteins are the main molecular components of the arterial wall. Alterations in the amounts of specific proteins in both the extracellular matrix and in vascular cells are believed to be associated with different arterial pathologies, however only sparse data is currently available, particularly in relation...
Conference Abstract
11. WAVE POTENTIAL: A UNIFIED MODEL OF ARTERIAL WAVES, RESERVOIR PHENOMENA AND THEIR INTERACTION
Jonathan P. Mynard, Joseph J. Smolich
Pages: 45 - 46
Models of haemodynamics play a central role in current research directed to understanding and addressing cardiovascular disease. Although conventional windkessel and wave models are very useful, they are incompatible due to conflicting assumptions and neither comprehensively explain the basis and interdependencies...
Conference Abstract
12. VASCULAR DYSFUNCTION: AT THE HEART OF CARDIOVASCULAR DISEASE, COGNITIVE IMPAIRMENT AND DEPRESSIVE SYMPTOMS
Thomas van Sloten
Pages: 46 - 46
Vascular dysfunction may be an important pathway through which ageing and other factors, such as diabetes and obesity, can cause diseases of the heart and brain. Vascular dysfunction includes dysfunction of large arteries (due to arterial stiffness), the microcirculation (microvascular dysfunction) and...
Conference Abstract
13. ARTERIAL INFLAMMATION, BLOOD PRESSURE AND CENTRAL HEMODYNAMICS – THE ABC OF DIABETIC ANGIOPATHY
Simone Theilade
Pages: 46 - 46
Aim: In diabetes patients, we explored relationships between markers of diabetic angiopathy, diabetic complications and adverse outcome.
Methods: Patients were recruited from 3 observational studies from Steno Diabetes Center, Denmark and one randomized, double-blind, international, multicentre study.
We...
Conference Abstract
14. WHY DOES NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) CONTRIBUTE TO CARDIOVASCULAR OUTCOMES?
Hannele Yki-Järvinen
Pages: 46 - 47
Take home messages
1.Both ‘Metabolic NAFLD’ and the features of insulin resistance/the metabolic syndrome (MetS) increase the risk of cardiovascular disease (CVD), even independent of obesity
2.‘Metabolic NAFLD’ and insulin resistance share common pathophysiology, which may explain their link with...
Conference Abstract
15. CONSTITUENT BASED MODELLING OF ARTERIAL WALL MECHANICS
Lydia Aslanidou, Rodrigo Araujo Fraga da Silva, Patrick Segers, Nikos Stergiopulos
Pages: 47 - 47
In the preclinical setting, Angiotensin-II infusion has been the most popular model for mouse aneurysm research in the last 15 years. Nonetheless, little is known about the ascending aortic aneurysm pathobiology of this model and several lingering questions regarding the abdominal aortic aneurysm pathology...
Conference Abstract
16. ARTERIAL STIFFNESS IN INFLAMMATORY DISEASE
Kaisa Maki-Petaja
Pages: 47 - 47
Many inflammatory conditions are associated with an increased risk of cardiovascular disease (CVD) and mortality. As well as accelerated atherosclerosis, increased plaque instability and endothelial dysfunction; arterial stiffness has been proposed as one of the potential mechanisms underlying the increased...
Conference Abstract
17. 1.1 DIABETES AND CENTRAL BLOOD PRESSURE IN CORONARY PATIENTS
Piotr Jankowski, Dorota Debicka-Dabrowska, Malgorzata Kloch-Badelek, Leszek Bryniarski, Kalina Kawecka-Jaszcz, Danuta Czarnecka
Pages: 48 - 48
Background: Relative (represented by pulsatility) as well as absolute (pulse pressure) changes of central blood pressure (BP) were shown to predict cardiovascular (CV) complications in coronary patients. However, the influence of diabetes (a major CV risk factor) on the values of BP-derived indices is...
Conference Abstract
18. 1.2 HOW DOES OBESITY INFLUENCE ARTERIAL STIFFNESS IN ASYMPTOMATIC ADULTS?
Bela Benczur, Renata Bocskei, Attila Cziraki
Pages: 48 - 48
Central obesity is an important cause of cardiovascular disease. It’s well-known that aortic pulse wave velocity (aoPWV) is a strong predictor of cardiovascular events. However the potential correlation between fat accumulation and increased arterial stiffness is poorly investigated. The aim of this...
Conference Abstract
19. 1.3 CENTRAL PRESSURES AND WAVE REFLECTIONS ARE INDEPENDENTLY ASSOCIATED WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS IN MEN WITH ERECTILE DYSFUNCTION
Nikitas Skliros, Nikolaos Ioakeimidis, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Athanasios Aggelis, Dimitrios Toulousis
Pages: 48 - 49
Purpose: Erectile dysfunction (ED) confers an independent risk for cardiovascular events and total mortality. Central pressures and wave reflection indices independently predict cardiovascular events. Aim of this study is to investigate whether central haemodynamics predict major adverse cardiovascular...
Conference Abstract
20. 2.1 THE RELATIVE IMPORTANCE OF CENTRAL AND BRACHIAL BLOOD PRESSURE IN PREDICTING CARDIOVASCULAR EVENTS: AN INDIVIDUAL PARTICIPANT META-ANALYSIS OF PROSPECTIVE OBSERVATIONAL DATA FROM 22,433 SUBJECTS
Carmel McEniery, Yoav Ben-Shlomo, Margaret May, Melissa Spears, Lyndia Brumback, James Cameron, Chen-Huan Chen, Julio Chirinos, Danuta Czarnecka, Anthony Dart, Richard Devereux, Neeraj Dhaun, Daniel Duprez, Shih-Jen Hwang, David Jacobs, Piotr Jankowski, Julie Janner, Peter Lacy, Gary Mitchell, Riccardo Pini
Pages: 49 - 49
Systolic blood pressure (SBP) differs between the brachial artery and aorta. Prospective data suggest that central pressure predicts future cardiovascular events, but it is unclear if it is superior to brachial pressure.
Methods and Results: A systematic review and individual participant data meta-analysis...
Conference Abstract
21. 2.2 CENTRAL-TO-PERIPHERAL DIASTOLIC BLOOD PRESSURE ATTENUATION IN HEALTHY ADOLESCENTS AND THE EFFECTS OF HEART RATE. THE MACISTE STUDY
Giacomo Pucci, Francesca Battista, Leandro Sanesi, Sara Alessio, Giuseppe Schillaci
Pages: 49 - 49
Background: Heart rate (HR) is directly associated to central-to-peripheral pulse wave amplification. We aimed at evaluating the associations between heart rate and each BP component in a cohort of healthy adolescents.
Objective: 470 healthy adolescents (17±1.4 years, 56% boys, brachial BP 123/67±11/7...
Conference Abstract
22. 2.3 DETERMINANTS OF INAPPROPRIATELY HIGH PULSE WAVE VELOCITY IN HYPERTENSIVE PATIENTS: A RETROSPECTIVE CROSS-SECTIONAL COHORT STUDY
Marina Di Pilla, Rosa Maria Bruno, Simona Buralli, Melania Sgro’, Piero Amedeo Modesti, Stefano Taddei, Lorenzo Ghiadoni
Pages: 49 - 50
Background: Age and blood pressure (BP) are known to be the main determinants of large artery stiffness. However other factors may lead to an inappropriately high pulse wave velocity (PWV). We investigated the determinants of inappropriately high PWV in hypertensive patients and their possible role in...
Conference Abstract
23. 2.4 SODIUM CONSUMPTION, CENTRAL AND PERIPHERAL BLOOD PRESSURE, AND FOOD HABITS IN A POPULATION OF HEALTHY ADOLESCENTS. THE MACISTE STUDY
Giacomo Pucci, Francesca Battista, Marco D’Abbondanza, Leandro Sanesi, Giuseppe Schillaci
Pages: 50 - 50
Objective: The relationship between sodium consumption, central BP and the main dietary sources of daily sodium intake in adolescence has been poorly explored. We have evaluated sodium intake, central and peripheral BP in a population of Italian adolescents.
Methods: 401 healthy adolescents aged 17±1...
Conference Abstract
24. 2.5 THE EFFECT OF RENAL DENERVATION ON CENTRAL BLOOD PRESSURE AND ARTERIAL STIFFNESS IN TREATMENT RESISTANT ESSENTIAL HYPERTENSION: A SUBSTUDY OF A RANDOMIZED SHAM-CONTROLLED DOUBLE-BLINDED TRIAL (THE RESET TRIAL)
Christian D. Peters, Ole N. Mathiasen, Henrik Vase, Jesper Bech, Kent L. Christensen, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Ulla Kampmann, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Hans E. Bøtker, Morten Engholm, Jannik B. Bertelsen, Jens F. Lassen, Erling B. Pedersen, Anne Kaltoft, Niels H. Buus
Pages: 50 - 50
Background: A recent sham-controlled trial (ReSET) showed no sustained effect of renal denervation (RDN) on 24-hour ambulatory blood pressure (24hA-BP) measurements in patients with treatment resistant hypertension.1 The aim of this substudy was to investigate, whether RDN affects central blood pressure...
Conference Abstract
25. 2.7 NON-INVASIVE EVALUATION OF END SYSTOLIC LEFT VENTRICULAR ELASTANE ACCORDING TO PRESSURE-VOLUME CURVE MODELLING DURING EJECTION IN ARTERIAL HYPERTENSION
Benjamin Bonnet, Frank Jourdan, Guilhem du Cailar, Pierre Fesler
Pages: 50 - 50
Objective: Non invasive methods have been proposed to assess end systolic left ventricular (LV) elastance (Ees), but clinical application remains complex. The aim of the present study was to 1) estimate Ees according to modeling of LV pressure-volume (P-V) curve during ejection and validate our method...
Conference Abstract
26. 3.1 REDUCING ARTERIAL STIFFNESS INDEPENDENTLY OF BP: PROOF OF CONCEPT? CAVI, PWV AND CARDIAC DATA IN THE 6-MONTH VASERA TRIAL
Charlotte Mills, Luca Faconti, Virginia Govoni, Steve Morant, Maria-Linda Casagrande, Haotian Gu, Benyu Jiang, Andrew Webb, Kennedy Cruickshank
Pages: 51 - 51
Purpose/ background/ objectives: People with or at risk of Type II diabetes (T2DM) are at increased risk of vascular disease and arterial stiffness (AS). We hypothesized that spironolactone and dietary nitrate (beetroot juice) separately and together would reduce AS, measured as cardiac-ankle vascular...
Conference Abstract
27. 3.2 VARIABILITY IN MEAN ARTERIAL PRESSURE AND DIASTOLIC BLOOD PRESSURE FROM CENTRAL TO PERIPHERAL LARGE ARTERIES: RELEVANCE TO ARTERIAL PHYSIOLOGY AND ESTIMATED CENTRAL BLOOD PRESSURE
Martin Schultz, Dean Picone, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Phillip Roberts-Thomson, James Sharman
Pages: 51 - 51
Background: Mean arterial pressure (MAP) and diastolic blood pressure (DBP) are thought to consistently decline approximately 1–3 mmHg from the aorta to peripheral large arteries, thus providing a small pressure gradient to aid blood flow. The magnitude of this gradient is important for correct waveform...
Conference Abstract
28. 3.3 DISCOVERY OF A NEW BLOOD PRESSURE PHENOTYPE FROM INVASIVE CENTRAL-TO-PERIPHERAL RECORDINGS: IMPLICATIONS FOR BRACHIAL CUFF ACCURACY AND CARDIOVASCULAR RISK ASSESSMENT
Dean Picone, Martin Schultz, Xiaoqing Peng, Andrew Black, Nathan Dwyer, Phil Roberts-Thomson, Velandai Srikanth, James Sharman
Pages: 51 - 51
Background: Accuracy of brachial cuff blood pressure (BP) may be influenced by individual variability in central-to-peripheral systolic BP (SBP)-amplification, but this has never been determined. We aimed to achieve this by characterising SBP-amplification phenotypes and examining associations with cuff...
Conference Abstract
29. 3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION
Junjing Su, Charlotte Manisty, Kim H. Parker, Soren Mellemkjaer, Luke Howard, Ulf Simonsen, Alun Hughes
Pages: 51 - 52
Background: The objective of the study was to apply wave intensity analysis (WIA) in the pulmonary artery to characterise the magnitude, origin, type and timing of arterial waves in individuals with and without pulmonary hypertension (PH).
Methods: Right heart catheterisation was performed using a pressure...
Conference Abstract
30. 3.5 NON-INVASIVE US-BASED WAVE INTENSITY ANALYSIS IN MICE
Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesca Lenzarini, Francesco Faita
Pages: 52 - 52
Wave Intensity Analysis (WIA) can provide information about the interaction between vascular and cardiac system. WIA-derived indexes have quantitative physiological meaning. We investigated age-associated changes in WIA-derived parameters in mice and correlated them with biomarkers of cardiac function.
Sixteen...
Conference Abstract
31. 3.6 LONGITUDINAL CHANGES IN AORTIC RESERVOIR FUNCTION INDEPENDENTLY PREDICT DECLINING RENAL FUNCTION AMONG HEALTHY INDIVIDUALS
Rachel Climie, Dean Picone, James Sharman
Pages: 52 - 52
Objectives: Aortic reservoir function independently predicts end organ damage in cross sectional analyses. However, longitudinal associations are more important regarding causation, but this has never been examined and was the goal of this study.
Methods: Aortic reservoir function (excess pressure integral...
Conference Abstract
32. 3.7 ARTERIAL STIFFNESS FOR THE EARLY PREDICTION OF PRE-ECLAMPSIA COMPARED WITH CLINICAL CHARACTERISTICS, UTERINE ARTERY DOPPLER INDICES, AND ANGIOGENIC BIOMARKERS
Kim Phan, Yessica Haydee Gomez, Jessica Gorgui, Amira El-Messidi, Robert Gagnon, Stella Daskalopoulou
Pages: 52 - 52
Objective: To develop a model for the 1st trimester prediction of pre-eclampsia.
Methods: In this prospective longitudinal study, women with high-risk singleton pregnancies were recruited and arterial stiffness was measured using applanation tonometry (SphygmoCor, AtCor) and compared between women who...
Conference Abstract
33. 3.8 CAN ARTERIAL WAVE AUGMENTATION IN YOUNG ADULTS EXPLAIN VARIABILITY OF CARDIOVASCULAR RISK IN ETHNIC MINORITIES?
Luca Faconti
Pages: 52 - 53
Objective: Traditional cardiovascular (CV) risk factors do not fully explain ethnic differences in CV disease [1,2]. We tested if pulse wave velocity (PWV) and Augmentation Index (AIx) and their determinants from childhood may underlie ethnic variability in CV risk as young adults in the ‘DASH’ longitudinal...
Conference Abstract
34. 3.9 ASSOCIATIONS OF BLOOD PRESSURE THROUGHOUT CHILDHOOD WITH LEFT VENTRICLE MASS IN ADOLESCENCE
Chloe Park, Nish Chaturvedi, Alun Hughes
Pages: 53 - 53
Background: High blood pressure (BP) is a major risk factor for elevated LV mass (LVM) in adults. Evidence suggests that BP tracks from childhood into adolescence and adulthood, however findings on the association between childhood BP and LVM are inconsistent and the temporal relationship between BP...
Conference Abstract
35. 4.1 TNF- ANTAGONISTS IMPROVE ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS: A META-ANALYSIS
Georgios Georgiopoulos, Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Athanasios Gravos, Panagiota Pietri, Christos Georgakopoulos, Kimon Stamatelopoulos, Dimitrios Tousoulis
Pages: 53 - 54
Purpose/Background/Objectives: Patients with rheumatoid arthritis (RA) have a higher arterial stiffness than their age-matched healthy counterparts and an increased inflammatory burden that might be associated with their increased cardiovascular risk. Tumor necrosis factor alpha (TNF)-antagonists have...
Conference Abstract
36. 4.2 WITHDRAWAL OF STATINS THERAPY IN PATIENTS AFTER CAROTID ENDARTERECTOMY ASSOCIATED WITH INCREASING RISK OF SIGNIFICANT RESTENOSIS
Olga Tereshina, Alexcey Vachev
Pages: 54 - 54
Background: The benefit of carotid revascularization is decreased by the occurrence of restenosis at the site of surgery, which is associated with a modestly increased risk of stroke. Preventing restenosis plays pivotal role in the overall treatment and prevention of stroke in patients with carotid artery...
Conference Abstract
37. 4.3 ELECTRONIC CIGARETTE SMOKING INCREASES AORTIC STIFFNESS IN YOUNG SMOKERS
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Mahmud Abdelrasoul, Christos Georgakopoulos, Panagiota Pietri, Christodoulos Stefanadis, Dimitrios Tousoulis
Pages: 54 - 54
Purpose/Background/Objectives: Smoking increases aortic stiffness which is an important predictor of cardiovascular risk. Electronic cigarettes (EC) simulate tobacco cigarette (TC) and have been advocated as a less harmful alternative. We investigated the acute effect of EC smoking on aortic stiffness...
Conference Abstract
38. 4.4 ARTERIAL PHENOTYPE MODULATION AND REGULATION OF VASCULAR FIBROSIS IN MICE BY CONDITIONAL INACTIVATION OF INTEGRIN AV SUBUNIT IN VASCULAR SMOOTH MUSCLE CELLS
Ekaterina Belozertseva, Huguette Louis, Zhenlin Li, Mustapha Bourhim, Dominique Dumas, Veronique Regnault, Patrick Lacolley
Pages: 54 - 55
Integrin αv functions as a receptor for adhesion proteins and is expressed at high density in vascular smooth muscle cells (VSMC)1,2,3,4,5 whose phenotypic modulation plays a crucial role in arterial ageing and atherosclerosis.6,7.
Our aim was to define the arterial phenotype in mice conditionally inactivated...
Conference Abstract
39. 4.5 U-SHAPED RELATIONSHIP OF RESERVOIR PRESSURE TO CARDIOVASCULAR EVENTS IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Stephanie Parragh, Bernhard Hametner, Christopher Mayer, Siegfried Wassertheurer, Thomas Weber
Pages: 55 - 55
Objectives: Parameters of aortic stiffness are considered important indicators of cardiovascular risk. However, in heart failure with reduced ejection fraction (HFrEF), their association to outcome was found to be inversed. The aim of this work was to analyze the relationship of the amplitude of reservoir...
Conference Abstract
40. 4.6 BEAT-BY-BEAT ASSESSMENT OF CARDIAC AFTERLOAD USING AORTIC PU LOOP – A PILOT STUDY
Arthur Le Gall, Jona Joachim, Joaquim Mateo, Alexandre Mebazaa, Etienne Gayat, Fabrice Vallée
Pages: 55 - 56
Purpose/Background/Objectives: Cardiac afterload evaluation is crucial during general anesthesia (GA) especially during hypotension episode. Using beat to beat aortic pressure (P) / flow velocity (U) loop constructed from routine signals recorded during GA might allow to track afterload changes.
Methods:...
Conference Abstract
41. 4.7 MEASUREMENT OF ARTERIAL STIFFNESS USING A CONNECTED BATHROOM SCALE: CALIBRATION AGAINST SPHYGMOCOR
Pierre Boutouyrie, Hakim Khettab, David Campo, Roger Yu, Nadine Buard
Pages: 56 - 56
Background: Measurement of arterial stiffness (AS) is still considered difficult. We developed a non-invasive technique to assess AS from a connected bathroom scale, based on ballistocardiography (BCG) and impedance plethysmography (IPG).
Methods: We included 198 subjects and patients, 111 for calibration...
Conference Abstract
42. 4.8 INCREASED CARDIAC WORKLOAD IN THE UPRIGHT POSTURE IN MALE SUBJECTS: NON-INVASIVE HEMODYNAMICS IN MEN VERSUS WOMEN
Pauliina Kangas, Anna Tahvanainen, Antti Tikkakoski, Jenni Koskela, Marko Uitto, Jari Viik, Mika Kahonen, Tiit Koobi, Emeritus Jukka Mustonen, Ilkka Porsti
Pages: 56 - 56
Background: Men and women differ in the risk of cardiovascular disease, but the underlying mechanisms are not completely understood. We examined possible sex-related differences in supine and upright cardiovascular regulation.
Methods: Hemodynamics were recorded from 167 men and 167 women of matching...
Conference Abstract
43. 4.9 PROPORTIONAL PRESSURE RELATIONS IN THE PULMONARY ARTERIAL SYSTEM
Nico Westerhof, Louis Handoko
Pages: 56 - 56
Background – Objectives: The pulmonary arterial system can be characterized by:
1.A constant product of Pulmonary Vascular Resistance (PVR) and Total Arterial Compliance (TAC) with Tau=PVRxTAC≈0.7 seconds (1).
2.A proportional relation exits between systolic and diastolic pulmonary artery pressure,...
Conference Abstract
44. 5.1 MILD REDUCTION OF GLOMERULAR FILTRATION RATE IS ASSOCIATED WITH INCREASED SYSTEMIC VASCULAR RESISTANCE INDEPENDENT OF CHANGES IN CARDIAC AUTONOMIC TONE
Ilkka Porsti, Kati Vaaraniemi, Pauliina Kangas, Antti Tikkakoski, Jenni Koskela, Anna Tahvanainen, Arttu Eraranta, Jukka Mustonen
Pages: 56 - 57
Objective: Our aim was to evaluate the influence of mild impairment in kidney function on hemodynamics and cardiac autonomic tone.
Methods: We studied 561 (50% male) normotensive and hypertensive subjects without kidney or other cardiovascular diseases or antihypertensive treatment. Supine and upright...
Conference Abstract
45. 5.2 AN ASSOCIATED WITH FAMILIAL HEMIPLEGIC MIGRAINE TYPE 2 MUTATION IN THE ALPHA-2 ISOFORM NA,K-ATPASE DISTURBS VASCULAR RESPONSES IN MOUSE BRAIN
Christian Staehr, Lise Hangaard, Karin Lykke-Hartmann, Elena Bouzinova, Christian Aalkjaer, Vladimir Matchkov
Pages: 57 - 57
Objectives: Migraine attack is associated with severe changes in brain perfusion vasoconstriction-induced hypoxemia during aura and rebound vasodilation in subsequent headache. Familial Hemiplegic Migraine Type 2 is associated with point mutations (including G301R) in the α2 isoform Na,K-ATPase. Heterozygote...
Conference Abstract
46. 5.3 REVERSIBILITY OF ARTERIAL STIFFNESS AFTER KIDNEY TRANSPLANTATION: SYSTEMATIC REVIEW AND META-ANALYSIS
Aboubacar Sidibe, Catherine Fortier, Marie-Pier Desjardins, Fabrice Mac-Way, Sacha De Serres, Mohsen Agharazii
Pages: 57 - 57
Background: Chronic kidney disease is associated with increased arterial stiffness. Correction of the uremic milieu by kidney transplantation (KTx) may be improve arterial stiffness. However, results from clinical studies are not uniformly convincing. This could be related to small sample size of studies,...
Conference Abstract
47. 5.4 HIGH PWV IS ASSOCIATED WITH NANO-SCALE CHANGES IN THE MEDIAL LAYER OF THE INTERNAL MAMMARY ARTERY
Riaz Akhtar, Zhuo Chang, Maria Lyck Hansen, Lars Melholt Rasmussen
Pages: 57 - 57
Background: Arterial stiffening occurs as part of the natural ageing process. Degradation of the extracellular matrix (ECM) in the medial layer is typically implicated in arterial stiffening. However, little is known about how localised changes in arteries in terms of both structure and mechanical properties...
Conference Abstract
48. 5.5 AGE-DEPENDENT TELOMERE ATTRITION, SHORT TELOMERES AND ATHEROSCLEROSIS
Simon Toupance, Anna Kearney-Schwartz, Mohamed Temmar, Cécile Lakomy, Carlos Labat, Patrick Rossignol, Faiez Zannad, Patrick Lacolley, Abraham Aviv, Athanase Benetos
Pages: 57 - 58
Background: Short leukocyte telomere length (LTL) is associated with atherosclerosis. The prevailing view is this association exists since LTL is a biomarker of cumulative inflammation and oxidative stress during adult life. However recent studies show that LTL in adults is defined mainly by LTL at birth...
Conference Abstract
49. 5.6 CARDIOVASCULAR CONSEQUENCES OF EXTREME PREMATURITY: A FOLLOW-UP FROM THE EPICURE STUDY
Carmel McEniery, Joanne Beckman, Ian Wilkinson, Neil Marlow, John Cockcroft
Pages: 58 - 58
Background: Long-term outcomes following extremely preterm (EP) birth are becoming increasingly relevant, given improved survival rates. We previously reported altered arterial haemodynamics in 11 year olds who were <25 weeks gestation. The same individuals have now been re-evaluated in young adulthood.
Methods:...
Conference Abstract
50. 6.1 PERIPHERAL ARTERY DISEASE AND CENTRAL HEMODYNAMIC MODIFICATION
Mariella Catalano, Gabriel Dimitrov, Giovanni Scandale, Marzio Minola, Martino Recchia, Francesca Galli, Maria Carotta, Gianni Carzaniga
Pages: 59 - 59
Peripheral arterial disease (PAD) affects the hemodynamics of the lower limbs1 and is associated with increased cardiovascular risk and mortality2. The aim of this study was to evaluate central hemodynamics and to test the relationships between lower ankle-pressure index (ABI) and Augmentation index...
Conference Abstract
51. 6.2 IMPACT OF DIABETES ON ARTERIAL STIFFNESS
Rogerio Toshiro Passos Okawa, Jorge Juarez Vieira Teixeira, Alex Cardoso Perez, Eigi Wilton de Souza, Giovanna Chiqueto Duarte, Guilherme Norio Hayakawa, Lorena Lima Gargaro, Marina Franciscon Gomes da Cruz, Michel Lima Moro Alves, Milene Cripa Pizatto de Araujo, Patrick Sadao Nishikawa, Rafaela Pelisson Regla, Rafael Campos do Nascimento
Pages: 59 - 59
Objectives/Background: The purpose of our study was to examine the impact of diabetes on arterial stiffness.
A systematic review, published by Cecelja and Chowienczyk (1), describes that pulse wave velocity (PWV), is highly predictive of cardiovascular events, and PWV is associated with age and blood-pressure,...
Conference Abstract
52. 6.3 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOW-DENSITY NON-CALCIFIED CORONARY PLAQUES IN PATIENTS WITH TYPE 2 DIABETES AND HEALTHY CONTROLS
Kristian L. Funck, Esben Laugesen, Kristian Oevrehus, Jesper M. Jensen, Bjarne L. Noergaard, Damini Dey, Troels K. Hansen, Per L. Poulsen
Pages: 59 - 60
Background: Arterial stiffness may provide non-invasive information about cardiovascular risk in patients with type 2 diabetes. We investigated the association between arterial stiffness and subclinical coronary atherosclerosis in patients with type 2 diabetes and healthy controls.
Methods: Patients...
Conference Abstract
53. 6.4 LARGE AND SMALL ARTERY CROSSTALK IN PATIENTS WITH TYPE 2 DIABETES
Jonathan Mathias Baier, Esben Laugesen, Søren Tang Knudsen, Per Løgstrup Poulsen, Toke Bek
Pages: 60 - 60
Background: Vascular complications to diabetes mellitus have, traditionally, been divided in to micro- and macroangiopathy. However, a growing body of evidence has put this categorical division into question, as large artery stiffness has been associated with microvascular complications in diabetics,...
Conference Abstract
54. 6.5 ASSOCIATION BETWEEN INCREASED ARTERIAL STIFFNESS AND HBA1C AND LDL CHOLESTEROL LEVEL IN TYPE 2 DIABETES PATIENTS
Ilona Hegyi, Terez Szabo, Eszter Szele, Istvan Vasas
Pages: 60 - 60
Background: In patient with type 2 diabetes mellitus (T2DM) the atherosclerosis apper in younger age, in both gender and the cardiovascular risk is much higher. The aim of our study was to examine the association between pulse wave velocity (PWV) and glycated haemoglobin (HbA1c) and low density lipoprotein...
Conference Abstract
55. 6.6 AORTIC-BRACHIAL STIFFNESS MISMATCH IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS
Ekaterina Starostina, Elena Troitskaya, Yulia Kotovskaya, Zhanna Kobalava
Pages: 60 - 61
Background: Patients with type 2 diabetes have a high risk of CVD. Arterial stiffness gradient is a new prognostic predictor of mortality previously assessed only in dialysis population1–2.
The aim of the study was to assess arterial stiffness and stiffness gradient in diabetic patients with arterial...
Conference Abstract
56. 6.7 FIRST EVIDENCE OF PULSATILE PRESSURE INTERACTION BETWEEN THE MACRO-VASCULATURE AND MICRO-VASCULATURE: PROOF-OF-CONCEPT BY ASSOCIATION WITH KIDNEY DYSFUNCTION AMONG PATIENTS WITH TYPE 2 DIABETES
Rachel Climie, Dean Picone, Sarah Blackwood, Ahmad Qasem, Stephen Rattigan, James Sharman
Pages: 61 - 61
Objectives: It is widely thought that excess pulsatile pressure energy from increased stiffness of large central arteries (macro-vasculature) is transmitted to capillary networks (micro-vasculature) and causes end-organ damage (i.e. kidneys). However, this hypothesis has never been tested, and we sought...
Conference Abstract
57. 6.8 THE RELATIONSHIP BETWEEN DIASTOLIC FUNCTION AND CENTRAL HEMODYNAMICS IN DIABETIC HYPERTENSIVE PATIENTS
Davide Agnoletti, Filippo Valbusa, Ari Lieber, Guido Arcaro, Michel Safar, Jacques Blacher
Pages: 61 - 61
Background: Diabetic hypertensives patients present different hemodynamic pattern than only hypertensive patients. We aimed to investigate the relationship between the diastolic function and the pulse pressure amplification (PPA), an index combining both arterial stiffness and wave reflexion, in diabetic...
Conference Abstract
58. 6.9 ANTIPLATELET AND VASCULAR EFFECTS OF ASPIRIN IN HEALTHY PERSONS AND PATIENTS WITH TYPE 2 DIABETES
Liv Vernstroem Hald, Anne-Mette Hvas, Erik Lerkevang Grove, Esben Laugesen, Kristian Loekke Funck, Per Loegstrup Poulsen
Pages: 61 - 61
Background: Treatment with aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) in diabetes, whereas its place in primary prevention remains controversial.
The effect of once-daily aspirin on platelet aggregation is unclear in patients with diabetes. Furthermore, the...
Conference Abstract
59. 6.10 PERIPHERAL SENSORY NEUROPATHY AND VASCULAR ANGIOGENIC FACTORS IN TYPE 2 DIABETES PATIENTS IN GHANA
Kwame Yeboah, Daniel A. Antwi, Ben Gyan
Pages: 61 - 62
Background: Impaired angiogenesis may be amongst the possible mechanism underlining the development of peripheral sensory neuropathy (PSN) in type 2 diabetes (T2DM) patients.(1) Angiogenesis is regulated by circulating vascular growth factor, notably, angiopoietin (Ang)-1, Ang-2 and vascular endothelial...
Conference Abstract
60. 7.1 THE DETRIMENTAL EFFECTS OF LIVE FIREFIGHTING ON ARTERIAL FUNCTION IN FIREFIGHTERS
Alexander Rosenberg, Kanokwan Bunsawat, Tommy Wee, Tracy Baynard, Gavin Horn, Denise Smith, Bo Fernhall
Pages: 62 - 62
Background: Aging is associated with increased arterial stiffness and wave reflection, which is predictive of all-cause cardiovascular (CV) mortality (1–3). Firefighters have the highest cardiovascular mortality of any occupational group (4). High levels of heat stress, physical exertion, and elevated...
Conference Abstract
61. 7.2 POOR SLEEP QUALITY RELATED TO WORSE VASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS
Thessa Hilgenkamp, Garett Griffith, Robert Motl, Tracy Baynard, Bo Fernhall
Pages: 62 - 62
Background: Poor sleep quality has been related to poor vascular function and higher risk of cardiovascular disease in the general population. Persons with multiple sclerosis (MS) exhibit a high cardiovascular risk, and report poor sleep quality. To date, the association between sleep quality and vascular...
Conference Abstract
62. 7.3 ASSESSMENT OF BLOOD PRESSURE AND HEART RATE VARIABILITY IN MULTIPLE SCLEROSIS
Fatemeh Shirbani, Edward Barin, Mark Butlin, Alberto Avolio
Pages: 63 - 63
Background: Reported cardiovascular autonomic dysfunction (CAD) prevalence in Multiple Sclerosis (MS) varies between studies. As CAD lowers quality of life and may contribute to sudden death in MS, early CAD detection may assist treatment and risk identification.
Methods: In 23 MS patients and age and...
Conference Abstract
63. 7.4 HIGHER CAROTID STRAIN IN INDIVIDUALS WITH DOWN SYNDROME AT REST AND DURING HYPOVOLEMIC SYMPATHOEXCITATION
Sang Ouk Wee, Alexander Rosenberg, Bunsawat Kanokwan, Garett Griffith, Tracy Baynard, Bo Fernhall
Pages: 63 - 63
Background: Arterial stiffness and large artery function are independent risk factors for cardiovascular disease.(1) Individuals with Down Syndrome (DS) have autonomic dysfunction and known to have lower incidence of cardiovascular disease.(2) Limited literatures showed no difference in arterial stiffness...
Conference Abstract
64. 7.5 RETINAL VESSEL RESPONSES TO FLICKERING LIGHT PROVOCATION IN A COHORT OF BLACK AND WHITE TEACHERS: THE SABPA STUDY
Wayne Smith, Walthard Vilser, Konstantin Kotliar
Pages: 63 - 63
Background: Retinal microvascular function can be assessed using flicker light induced provocation (FLIP). Reduced vessel dilation responses to FLIP are noted in various disease conditions. Comparative studies between ethnic groups are scarce, while the importance of different phases of the vessel responses...
Conference Abstract
65. 7.6 THE DIFFERENCE IN GLUTATHIONE PEROXIDASE ACTIVITY ON ARTERIES OF A BI-ETHNIC POPULATION: THE SABPA STUDY
Johannes van Rooyen, Zurietta Schoeman, Carina Mels
Pages: 63 - 63
Background and objectives: From the literature it is evident that increased oxidative stress is integral in the development of cardiovascular disease. We therefore aimed to compare glutathione peroxidase (GPx) and glutathione reductase (GR) activity between black and white Africans, and to investigate...
Conference Abstract
66. 7.7 THE EFFECT OF MARINE N-3 POLYUNSATURATED FATTY ACIDS ON CARDIAC AUTONOMIC AND HEMODYNAMIC FUNCTION IN PATIENTS WITH PSORIATIC ARTHRITIS: A RANDOMISED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL
Salome Kristensen, Erik Berg Schmiddt, Annette Schlemmer, Claus Rasmussen, Esther Lindgreen, Martin Berg Johansen, Jeppe Hagstrup Christensen
Pages: 64 - 64
Background: Patients with psoriatic arthritis are at high cardiovascular risk. Marine n-3 polyunsaturated fatty acids (PUFA) may reduce the incidence of cardiovascular disease. The aim of this study was to investigate the effect of marine n-3 PUFA on cardiac autonomic function and vascular function in...
Conference Abstract
67. 7.8 ARTERIAL STIFFNESS AND SYSTEMIC INFLAMMATION IN COPD PATIENTS
Renata Marietta Bocskei, Lilla Tamasi, Bela Benczur, Attila Cziraki, Gyorgy Losonczy, Aniko Bohacs
Pages: 64 - 64
Background: COPD is one of the leading causes of mortality worldwide. Systemic low-grade inflammation is a common finding in COPD. Soluble urokinase-type plasminogen activator receptor (suPAR) indicates an inflammatory state and it has an association with atherosclerosis and cardiovascular disease (CVD)....
Conference Abstract
68. 7.9 CAROTID ARTERY STIFFNESS IS ASSOCIATED WITH CT-MEASURED LUNG AIR-TRAPPING IN COPD PATIENTS AND CONTROLS INDEPENDENT OF AGE, BLOOD PRESSURE AND SMOKING HISTORY
Gary Pierce, John Newell, Alejandro Comellas, Eric Hoffman, Kelsey Warner, Anna Croghan, Lyndsey DuBose, Peg Nopoulos, Vince Magnotta, Stephan Arndt, Karin Hoth
Pages: 64 - 64
Background: Early stages of chronic obstructive pulmonary disease (COPD) are characterized by loss of the terminal bronchioles and ‘air trapping’ often before overt emphysema manifests (1). COPD patients are also at risk for cardiovascular disease (CVD), therefore, we hypothesized that the degree of...
Conference Abstract
69. 7.10 AORTIC STIFFNESS AND BODY MASS INDEX (BMI) IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
Nichola Gale, Ali Albarrati, Margaret Munnery, Dennis Shale, John Cockcroft
Pages: 64 - 65
Background: Patients with COPD have increased Cardiovascular (CV) risk and commonly present with altered body composition. Patients with COPD and a low BMI have poorer health outcomes1, while obesity may increase CV risk2. The aim of this analysis was to explore BMI, CV risk, exercise capacity and systemic...
Conference Abstract
70. 8.1 ARTERIAL STIFFNESS, BLOOD PRESSURE AND CARDIAC OUTPUT STUDY
Suzanne Holewijn, Erik Groot Jebbink, Wim Aengevaeren, Jasper Martens, Marcel Hovens, Michel Reijnen
Pages: 65 - 65
We are planning a prospective study in 200 patients with an abdominal artery aneurysm (AAA). Non-invasive measurements will be performed including tonometry-based pulse wave analysis (PWA) and pulse wave velocity (PWV), echocardiography, and 24-hour blood pressure measurements.
This study will provide...
Conference Abstract
71. 8.3 QUANTIFYING HEART AND ARTERIAL CONTRIBUTIONS TO CENTRAL BLOOD PRESSURE IN SYSTOLE
Samuel Vennin, Ye Li, Marie Willemet, Henry Fok, Brian Clapp, Jordi Alastruey, Phil Chowienczyk
Pages: 65 - 65
Background: A recent study has shown that the central pressure waveform could be determined by a very small set of parameters accounting for the physical properties of the heart and the arteries [1]. Particularly, main pressure features like first systolic shoulder (P1) and systolic (P2) pressures were...
Conference Abstract
72. 8.4 DIURNAL CHANGES IN CENTRAL PRESSURE AND PULSE WAVE PARAMETERS IN HEALTHY SUBJECTS
Bernhard Hametner, Christopher Mayer, Jelena Köster, Johannes Weber, Michael Reppel, Klaas Franzen, Eugenijus Kaniusas, Siegfried Wassertheurer, Kai Mortensen
Pages: 65 - 65
Purpose: The feasibility of pulse wave analysis (PWA) over 24 hours with oscillometric devices has already been shown and first studies indicate additional information compared to single measurements. Nevertheless, diurnal patterns of PWA parameters in healthy subjects, which can potentially serve as...
Conference Abstract
73. 8.5 HEMODYNAMICS DURING INTRA- AND INTERDIALYTIC PERIODS DEPEND ON ULTRAFILTRATION VOLUME
Christopher Mayer, Stephan Geilert, Julia Matschkal, Uwe Heemann, Marcus Baumann, Christoph Schmaderer
Pages: 66 - 66
Introduction: Parameters of arterial stiffness are independent cardiovascular risk factors for end-stage renal disease patients. Significant changes of these parameters between intra- and interdialytic periods have been reported previously [1]. The aim of this cross-sectional study is to describe the...
Conference Abstract
74. 8.6 AEROBIC FITNESS LEVEL AND PERIPHERAL ARTERIAL COMPLIANCE – THE ROLE OF AUTONOMIC NERVOUS SYSTEM TONE
Nejka Potocnik, Ziva Melik, Ksenija Cankar, Martin Strucl
Pages: 66 - 66
Physical activity has beneficial effects on prevention of cardiovascular disease. Aerobic fitness is associated with higher central arterial compliance, but its effect on peripheral arterial compliance (pC) is controversial. We aimed to test the hypotheses that aerobic training augments pC at rest and...
Conference Abstract
75. 8.7 CHANGES IN CARDIAC FUNCTION BUT NOT STRUCTURE IN HEALTHY SUBJECTS WITH PREMATURE VASCULAR AGEING
Oscar Mac Ananey, Vincent Maher
Pages: 66 - 67
Purpose: Changes in myocardial and arterial wall properties/function are consistently reported in patients with established cardiovascular disease1. However, few studies have reported these changes in early subclinical disease. The aim of the present study was to examine cardiac and vascular changes...
Conference Abstract
76. 8.8 SYMPATHETIC VASOCONSTRICTOR RESPONSE TO LOWER BODY NEGATIVE PRESSURE IN YOUNG OBESE ADULTS: THE PRELIMINARY FINDING
Kanokwan Bunsawat, Georgios Grigoriadis, Bo Fernhall, Tracy Baynard
Pages: 67 - 67
Background: Elevations in muscle sympathetic nerve activity (MSNA) and sympathetic vasoconstrictor responsiveness to sympathoexcitation are associated with increased cardiovascular risks, which affect hemodynamics, and have been reported in obese adults with metabolic syndrome (1–3). It remains unclear...
Conference Abstract
77. 8.9 REDUCTION IN MYOCARDIAL WALL STRESS AND DELAYED MYOCARDIAL RELAXATION DURING EXERCISE
Haotian Gu, Xiaoli Zhang, Benyu Jiang, Sally Brett, Phil Chowienczyk
Pages: 67 - 67
Introduction: Myocardial wall stress (MWS) is thought to be the mechanical stimulus to ventricular hypertrophy (1,2). The objective of this study was to examine the effect of exercise on time-varying MWS (3).
Methods: Twelve subjects, aged 42.0 ± 16.8 (mean ± SD) years, systolic blood pressure (BP)...
Conference Abstract
78. 8.10 BRACHIAL ARTERY FLOW-MEDIATED DILATATION: DIFFERENT PATTERNS OF WALL SHEAR RATE INCREASE DURING REACTIVE HYPERAEMIA
Kunihiko Aizawa, Sara Sbragi, Alessandro Ramalli, Piero Tortoli, Francesco Casanova, Carmela Morizzo, Clare Thorn, Angela Shore, Phillip Gates, Carlo Palombo
Pages: 67 - 68
Background: Wall shear rate (WSR) is considered an important stimulus for flow-mediated dilatation (FMD). However, its estimation by conventional ultrasound is challenging due to inherent difficulties of velocity estimation near the arterial wall. To evaluate how WSR influences brachial artery FMD, we...
Conference Abstract
79. 8.11 CARDIO-ANKLE VASCULAR INDEX AND CAROTID-FEMORAL PULSE WAVE VELOCITY ARE CLOSELY ASSOCIATED WITH CHRONOLOGICAL AGE
L.B. Mendes, E. Bunting, K. Ali, J. Timeyin, C. Rajkumar
Pages: 68 - 68
Background: Vascular stiffening is part of the ageing process. However, it is not clear which vascular stiffness parameters are closely associated with chronological age.
Methods: Fifty-eight participants (38 men), age 69.57 ± 10.46 (mean ± SD, range = 47–90 years) who have had transient ischaemic attack...
Conference Abstract
80. 9.1 ULTRASOUND CHARACTERIZATION OF CARDIOVASCULAR ALTERATIONS IN YOUNG OB/OB MICE
Nicole Di Lascio, Claudia Kusmic, Francesco Stea, Francesco Faita
Pages: 68 - 68
Obesity is associated with diabetes and an increased cardiovascular risk. Leptin-deficient mice (ob/ob) are used as model of metabolic disease: they are characterized by obesity and insulin-resistance. Aim of this work is to identify early cardiovascular alterations in young ob/ob mice using micro-ultrasound...
Conference Abstract
81. 9.2 DELETION OF CHROMOSOME 9P21 NONCODING CARDIOVASCULAR RISK INTERVAL IN MICE INDUCES A PROTHROMBOTIC PHENOTYPE
Amel Mohamadi, Mustapha Bourhim, Gemma Basatemur, Huguette Louis, Athanase Benetos, Patrick Lacolley, Ziad Mallat, Veronique Regnault
Pages: 68 - 68
Background: SNPs on chromosome 9p21.3 risk locus have been associated with cardiovascular diseases. We have established a direct mechanistic link between 9p21 noncoding risk interval and susceptibility to aneurysm in a mouse model with a targeted deletion of the 9p21 noncoding cardiovascular disease...
Conference Abstract
82. 9.3 FUNCTIONAL AORTIC CHANGES INDUCED BY A HIGH SALT DIET
Kathleen Connolly, Mark Butlin, Bart Spronck, Carmel McEniery, Alberto Avolio, Ian Wilkinson
Pages: 68 - 69
Objective: This study examines effects of high salt diet on arterial blood pressure and aortic function in rats.
Methods: Sprague-Dawley rats were fed either high salt content chow or normal chow from weaning. Weight, tail-cuff systolic blood pressure (SBP), water and food intake, and urine output were...
Conference Abstract
83. 9.4 EVOLUTION OF CARDIAC FUNCTION AND METABOLISM DURING AGING IN A MURINE ANIMAL MODEL OF OBESITY
Delphine Lambert, Fatiha Maskali, Sylvain Poussier, Alexandra Clement, Jean-Loup Machu, Pierre-Yves Marie, Patrick Lacolley, Athanase Benetos, Laure Joly
Pages: 69 - 69
Purpose/Background/Objectives: Obesity is a well-known risk factor of cardiovascular diseases and a potentially modifiable determinant of arterial ageing. The objectives of this experimental study were to assess the effects of a long-term high fat diet (HFD) on metabolism, adipose tissues and phenotypes...
Conference Abstract
84. 9.5 COAGULATION CONTROL BY THE RHOA PATHWAY AND THE EXCHANGE FACTOR ARHGEF1
Camille Rouillon, Amel Mohammadi, Gervaise Loirand, Veronique Regnault, Patrick Lacolley
Pages: 69 - 69
Platelet activation by thrombin is an auto-amplification loop of thrombin generation, a major factor in the formation of atherosclerotic plaques. The small G protein RhoA, under the direct control of the exchange factor Arhgef1, modulates several cellular functions in inflammation. The objective was...
Conference Abstract
85. 9.6 VENTRICULAR VOLUME AND ARTERIAL FLOW DURING PRELOAD REDUCTION: AN MRI STUDY
Sandra Neumann, Gergely Szantho, Emma C. Hart, Nathan E. Manghat, Mark S. Turner, Mark C.K. Hamilton
Pages: 69 - 69
Lower body negative pressure (LBNP) has been used to assess the cardiovascular effect of preload reduction. We are the first to use MRI to investigate ventricular volumes and great vessel flow during LBNP.
13 volunteers (23–47 years) underwent LBNP at 0, −5 and −20mmHg. We acquired contiguous short...
Conference Abstract
86. 9.7 THORACIC AORTA PWV ASSESSMENT BY USING 4D FLOW IN MRI
Gilles Soulat, Umit Gencer, Nadjia Kachenoura, Konstantinos Stampoulis, Yousef Alattar, Emmanuel Messas, Olivier Villemain, Stéphane Laurent, Elie Mousseaux
Pages: 70 - 70
Purpose: In MRI, thoracic aorta pulse wave velocity (TAPWV) is usually estimated by 2D phase contrast (PC) with either in plane or through plane velocity acquisition. Thanks to technological improvement, 4D PC with full coverage of the TA and 3 dimension velocity encoding thought time can be now achievable...
Conference Abstract
87. 9.8 NEAR INFRARED SPECTROSCOPY (NIRS) CAN DETECT IMPROVEMENTS IN ARTERIAL FUNCTION FOLLOWING 6-MONTHS OF MARATHON TRAINING
Siana Jones, Andrew D’Silva, Alun Hughes
Pages: 70 - 70
Background: Endurance training improves vascular function and skeletal muscle perfusion. NIRS can measure changes in oxygenated haemoglobin (oxy-Hb) in the skeletal muscle microvascular bed. Therefore, combined with arterial occlusion, NIRS has the potential to assess microvascular function within skeletal...
Conference Abstract
88. 9.9 FLOW-MEDIATED SLOWING AS A NOVEL METHOD FOR THE NON-INVASIVE ASSESSMENT OF ENDOTHELIAL FUNCTION
Amedra Basgaran, Kaisa Maki-Petaja, Ian Wilkinson, Carmel McEniery
Pages: 70 - 70
Background: Flow-mediated slowing (FMS) assesses the slowing of pulse wave velocity (PWV) in response to reactive hyperaemia, to provide a measure of endothelial function. We assessed the reproducibility of FMS and whether the technique is sensitive to the influence of age. FMS was compared to the commonly...
Conference Abstract
89. 9.10 STRUCTURAL AND FUNCTIONAL ARTERIAL ABNORMALITIES IN FIBROMUSCULAR DYSPLASIA ARE IN THE CONTINUUM OF HYPERTENSION: AN IMAGING AND BIOMECHANICAL STUDY
Louise Marais, Pierre Boutouyrie, Hakim Khettab, Chantal Boulanger, Aurelien Lorthioir, Mickael Franck, Ralph Niarra, Jean-Marie Renard, Yann Chambon, Xavier Jeunemaitre, Mustapha Zidi, Pierre-François Plouin, Stéphane Laurent, Michel Azizi
Pages: 70 - 71
Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease of unknown origin. We previously showed the presence of triple signal (TS) at ultrasound within common carotid artery (CCA) wall. We aimed at coupling TS presence with microconstituents of the vessel wall.
We included...
Conference Abstract
90. 9.11 VASCULAR PHENOTYPING BY MEANS OF VERY HIGH-RESOLUTION ULTRASOUND IMAGING: A FEASIBILITY ANALYSIS
N. Di Lascio, R.M. Bruno, V. Gemignani, E. Bianchini, L. Ghiadoni, F. Faita
Pages: 71 - 71
Background: The study of medium and small-size arteries might be useful in the characterization of vascular adaptation, remodeling and wall ultrastructure modifications occurring with aging and in the presence of cardiovascular risk factors. However, to date, these districts have not been extensively...
Conference Abstract
91. 10.1 OPTIMAL AUTOMATED UNOBSERVED OFFICE BLOOD PRESSURE PROTOCOL: ONLY 6-MINUTES AND TWO READINGS MAY BE NEEDED
Myles Moore, Nathan Dwyer, Ella Hoban, Mark Nelson, Dean Picone, Martin Schultz, James Sharman
Pages: 71 - 71
Background: Automated office blood pressure (AutoBP) involving repeated, unobserved blood pressure (BP) readings during one clinic visit provides a practical alternative to daytime ambulatory blood pressure (ABP). However, the number of reading taken and measurement duration have varied across previously...
Conference Abstract
92. 10.2 EFFECTS OF INTER-ARM DIFFERENCES OF BRACHIAL SYSTOLIC BLOOD PRESSURE ON THE DERIVATION OF AORTIC SYSTOLIC PRESSURE
Alberto Avolio, Davis Theobald, Mitchel Cook, Karen Peebles, Mark Butlin
Pages: 71 - 71
Background: Inter-arm differences in brachial systolic blood pressure (SBP) should not theoretically translate to differences in calculated aortic SBP, there being only a single value of aortic blood pressure (BP) at any time.
Methods: This study assessed seated brachial and derived aortic SBP in 79...
Conference Abstract
93. 10.3 USE OF MICROLIFE BP WATCH IS A FEASIBLE APPROACH TO DETERMINE INTER-ARM BLOOD PRESSURE DIFFERENCES IN A CLINICAL SETTING
Christoffer Krogager, Esben Laugesen, Niklas B. Rossen, Per L. Poulsen, Mogens Erlandsen, Klavs W. Hansen
Pages: 71 - 72
Aim: The aim of this study is to evaluate the feasibility of Microlife Watch BP for measuring bilateral blood pressure (BP) in a clinical setting.
Method: 339 patients (85% diabetic) scheduled for ambulatory blood pressure monitoring at the outpatient clinic for endocrinology, Silkeborg Regional Hospital,...
Conference Abstract
94. 10.4 COMPARISON OF BLOOD PRESSURE VARIABILITY CALCULATED FROM PERIPHERAL AND DERIVED AORTIC BLOOD PRESSURE
Zahra Kouchaki, Mark Butlin, Ahmad Qasem, Alberto Avolio
Pages: 72 - 72
Background: Systolic blood pressure variability (SBPV), conventionally calculated from peripheral sites such as the arm or finger, may be of more utility when computed from central aortic values, as this has greater applicability to the heart and the baroreceptor function, due to central location of...
Conference Abstract
95. 10.5 COMPARISON OF ARTERIAL STIFFNESS ASSESSED BY POPMÈTRE® WITH ARTERIAL STIFFNESS ASSESSED BY APPLANATION TONOMETRY: A CLINICAL STUDY
Hasan Obeid, Hakim Khettab, Pierre Boutouyrie, Stephane Laurent, Magid Hallab
Pages: 72 - 72
Background: Large artery stiffness is recognized as a strong, independent marker of cardiovascular risk, mainly through aortic pulse wave velocity (PWV). pOpmètre® is a new non-invasive method, which estimates aortic PWV through finger-toe (FT) wave analysis. In a previous study, Alivon et al. have shown...
Conference Abstract
96. 10.6 VARIATION OF THE ASYMPTOTIC DIASTOLIC PRESSURE WITH DIFFERENT FITTING TECHNIQUES IN HEALTHY HUMANS
Nicola Pomella, Christina Kolyva, Ernst Rietzschel, Patrick Segers, Ashraf W. Khir, Madalina Negoita
Pages: 72 - 72
Background: Reservoir-wave model assumes the measured pressure (Pm) consists of two additive components: reservoir (Pr) and excess pressure (Pex)1–2. Calculation of Pr requires fitting the diastolic decay of Pm for calculating parameters P∞ (asymptotical value) and b (time constant)1. However, there...
Conference Abstract
97. 10.7 NON-INVASIVE ESTIMATION OF CENTRAL SYSTOLIC PRESSURE: A COMPARISON BETWEEN RADIAL ARTERY TONOMETRY AND A NEW DIRECT CENTRAL BLOOD PRESSURE ESTIMATION METHOD (DCBP)
Denis Chemla, Sandrine Millasseau, Edmund Lau, Nathalie Richard, Pierre Attal, Mabrouk Brahimi, Alain Nitenberg
Pages: 72 - 73
Background: We have developed a new proprietary method (DCBP® Direct Central Blood Pressure) to estimate central systolic blood pressure (cSBP) directly from peripheral pressure. In a previous meta-analysis of published high-fidelity pressure studies with simultaneous aortic and brachial pressure recordings,...
Conference Abstract
98. 10.8 SYSTOLIC AORTIC PRESSURE DERIVED FROM DIFFERENT CALIBRATION METHODS IN THE GENERAL POPULATION
Siegfried Wassertheurer, Bernhard Hametner, Christopher Mayer, Ahmed Hafez, Thomas Weber
Pages: 73 - 73
Background: There is recent evidence from different research groups that accuracy [1] and prognostic value [2,3,4] of systolic aortic pressure significantly depends on the method of calibration. Although these results consistently show superiority of mean pressure calibration (aSBP2) over both, traditional...
Conference Abstract
99. 10.9 ARTERIAL STIFFNESS INDEX BETA AND CARDIO-ANKLE VASCULAR INDEX INHERENTLY DEPEND ON BLOOD PRESSURE, BUT CAN BE READILY CORRECTED
Bart Spronck, Alberto Avolio, Isabella Tan, Mark Butlin, Koen Reesink, Tammo Delhaas
Pages: 73 - 73
Objectives: Arterial stiffness index β and cardio-ankle vascular index (CAVI) are widely accepted to quantify the blood pressure (BP)-independent, intrinsic exponent (β0) of the BP-diameter relationship. CAVI and β assume an exponential relationship between pressure (P) and diameter (d). We aim (1) to...
Conference Abstract
100. 10.10 HEMODYNAMIC CORRELATES OF THE LEFT VENTRICULAR MEAN EJECTION PRESSURE: A CAROTID TONOMETRY STUDY
Mathieu Jozwiak, Sandrine Millasseau, Jean-Louis Teboul, Jean-Emmanuel Alphonsine, Francois Depret, Nathalie Richard, Pierre Attal, Xavier Monnet, Denis Chemla
Pages: 74 - 74
Background: The systemic arterial load imposed to the left ventricle (LV) is a major determinant of normal/abnormal cardiovascular function. The LV mean ejection pressure (LVMEP) is the best estimate of load faced by the LV throughout ejection. The contribution of the steady and pulsatile blood pressure...
Conference Abstract
101. 11.1 ENDOTHELIAL FUNCTION IS IMPAIRED IN WOMEN WHO HAD PRE-ECLAMPSIA
Christian Delles, Catriona Brown, Joanne Flynn, Shona Kerr, David Carty
Pages: 74 - 74
Background: Women with a history of pre-eclampsia (PE) are at higher risk of cardiovascular disease later in life. We evaluated the cardiovascular health of women who had PE in comparison with women who had normotensive pregnancies.
Methods: We assessed heart rate-adjusted augmentation index (AIx SphygmoCor),...
Conference Abstract
102. 11.2 CORONARY ARTERY DISEASE TOPOGRAPHY IN RELATION TO RHEOLOGY OF THE PERIPHERAL SMALL ARTERIES IN MIDDLE AGED ERECTILE DYSFUNCTION MEN
Athanasios Angelis, Nikolaos Ioakimidis, Konstantinos Rokkas, Dimitrios Terentes, Ioanna Gourgouli, Christos Georgakopoulos, Konstantinos Aznaouridis, Charalampos Vlachopoulos, Dimitrios Tousoulis
Pages: 74 - 74
Background: Middle age represents a life period where incidence of cardiovascular events typically augments. Our aim is to investigate any association between peripheral vascular rheology and distribution of coronary artery disease (CAD) in middle aged erectile dysfunction (ED) population.
Methods:...
Conference Abstract
103. 11.3 ATHEROMATOSIS AND ENDOTHELIAL RESPONSE OF THE SMALL PERIPHERAL ARTERIES: A PERITONEAL DIALYSIS VERSUS HEMODIALYSIS PATIENTS MISMATCH
Athanasios Angelis, Nikolaos Ioakimidis, Penny Giannou, Ioannis Felekos, Vasiliki Kakiouzi, Konstantina Aggeli, Dimitrios Petras, Charalampos Vlachopoulos, Dimitrios Tousoulis
Pages: 74 - 74
Background: Peritoneal dialysis (PD) and hemodialysis (HD) are treatment options for end stage renal disease (ESRD). However, few are known on the cardiovascular impose of those therapeutic modalities. Our aim is to uncover endothelial damage and subclinical atheromatous process in male patients on chronic...
Conference Abstract
104. 11.4 RELATIONSHIP BETWEEN INFLAMMATORY CYTOKINES AND AORTIC STIFFNESS IN PATIENTS WITH CHRONIC KIDNEY DISEASE
Marie-Pier Desjardins, Aboubacar Sidibe, Catherine Fortier, Sacha De Serres, Richard Larivière, Mohsen Agharazii
Pages: 75 - 75
Introduction: Cardiovascular diseases are the primary cause of morbidity and mortality in patients with chronic kidney disease (CKD). Aortic stiffness is a non-traditional risk factor in these patients. Using an animal model of CKD with vascular calcification, we reported that inflammation is involved...
Conference Abstract
105. 11.5 DIFFERENCES OF HEART RATE VARIABILITY AND AUGMENTATION INDEX BETWEEN DIALYSIS AND POST-DIALYSIS PERIODS IN PATIENTS WITH END-STAGE RENAL DISEASE
Stefan Hagmair, Matthias Christoph Braunisch, Martin Bachler, Anna-Lena Hasenau, Axel Bauer, Konstantinos Rizas, Siegfried Wassertheurer, Marcus Baumann, Christopher Mayer, Christoph Schmaderer
Pages: 75 - 75
Introduction: Heart rate variability (HRV) analysis is a non-invasive tool for assessing the cardiac health. There is evidence that the cardiac autonomic system and central hemodynamics respond to hemodialysis. The aim of this work is to compare HRV parameters and augmentation index (AIx) between intra-...
Conference Abstract
106. 11.6 THE AORTIC-TO-BRACHIAL STIFFNESS GRADIENT AND AORTIC RESERVOIR-EXCESS PRESSURE IN A DIALYSIS POPULATION
Catherine Fortier, Marie-Pier Desjardins, Aboubacar Sidibe, Mathieu Allard, Martin G. Schultz, James E. Sharman, Mohsen Agharazii
Pages: 75 - 75
Background: Aortic reservoir function is associated with increased cardiovascular events. Patients with chronic kidney disease in need of dialysis have increased aortic stiffness and reversal of the aortic-to-brachial stiffness gradient, which could impair aortic reservoir function. The aim of this study...
Conference Abstract
107. 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE
Rasmus K. Carlsen, Christian D. Peters, Esben Laugesen, Simon Winther, Dinah S. Khatir, Hans E. Boetker, Morten Boettcher, Per Ivarsen, My Svensson, Niels H. Buus
Pages: 76 - 76
Background: We recently reported that central blood pressure (BP) obtained non-invasively in chronic kidney disease (CKD) patients significantly underestimated the central BP with decreasing eGFR in comparison with invasively measured true central BP in the aorta. This post-hoc analysis investigated...
Conference Abstract
108. 11.8 AORTIC SYSTOLIC BLOOD PRESSURE IS NO LONGER MARKER OF THE ARTERIAL STIFFNESS IN STABLE PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Evgeny Tyukhmenev, Svetlana Villevalde, Zhanna Kobalava
Pages: 76 - 76
The aim of the study was to assess arterial stiffness and its diagnostic and prognostic value in patients with arterial hypertension (AH) and heart failure with reduced ejection fraction (HFrEF).
Methods: In 93 stable patients (75% male, age 64±9 years (MSD), history of myocardial infarction 67%, diabetes...
Conference Abstract
109. 11.9 PARAMETERS OF ARTERIAL STIFFNESS HAVE INDEPENDENT PROGNOSTIC VALUE IN STABLE PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Evgeny Tyukhmenev, Svetlana Villevalde, Zhanna Kobalava
Pages: 76 - 76
The purpose of the study was to determine the prognostic value of ventricular-arterial coupling (VAC) in patients with arterial hypertension (AH) and stable heart failure with reduced ejection fraction (HFrEF).
Methods: In prospective study (follow-up 12–24 months, median 18 months) prognosis of 93...
Conference Abstract
110. 11.10 ARTERIAL ELASTANCE IS ASSOCIATED WITH CENTRAL BLOOD PRESSURE AND ARTERIAL PERIPHERAL RESISTANCE IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Evgeny Tyukhmenev, Svetlana Villevalde, Zhanna Kobalava
Pages: 76 - 76
Objective of the study was to assess ventricular-arterial coupling (VAC), parameters of left ventricular (LV) work efficiency and their determinants in patients with arterial hypertension (HTN) and stable heart failure with reduced ejection fraction (HFrEF).
Methods: In 93 stable patients with HTN and...
Conference Abstract
111. 12.1 EVALUATION OF ACUTE EFFECTS OF COFFEE CONSUMPTION ON ARTERIAL STIFFNESS IN HEALTHY ADULT PEOPLE USING AN OSCILLOMETRIC DEVICE
Pedro Forcada, Dario Echeverry, Alejandro Pizano, Felix Montes, Daniel Acuña
Pages: 77 - 77
Environment/Objectives: Several studies in different populations and conditions shown contradictory results about the effect of coffee on arterial stiffness (AS). Coffee consumption is high around the world and it is very important to define its CV effects.
To evaluate the acute effects on haemodynamic...
Conference Abstract
112. 12.2 HIGH PULSE WAVE VELOCITY IS ASSOCIATED WITH INCREASED VISIT-TO-VISIT SYSTOLIC BLOOD PRESSURE VARIABILITY IN CONTROLLED ARTERIAL HYPERTENSION
Elena Troitskaya, Yulia Kotovskaya, Zhanna Kobalava
Pages: 77 - 77
Background: Visit-to-visit blood pressure variability (BPV) is associated with adverse cardiovascular outcomes in different patients’ populations1–2. Arterial stiffness is a potential mechanism of increased visit-to-visit BPV3. Carotid–femoral PWV has become increasingly important for total cardiovascular...
Conference Abstract
113. 12.3 24 HOUR AMBULATORY BLOOD PRESSURE MONITORING AND PULSE WAVE VELOCITY PATTERNS IN KENYAN ADOLESCENTS
Anthony Etyang
Pages: 77 - 77
Background: There are no data on ambulatory blood pressure monitoring (ABPM) and arterial stiffness parameters in sub-Saharan African children. We performed 24-hour ABPM and pulse wave velocity (PWV) measurements in adolescents living in 2 slums in Nairobi, Kenya.
Methods: We selected 1,100 11–17 year...
Conference Abstract
114. 12.5 IMPAIRED REGULATION OF ARTERIAL WALL VISCOSITY DURING CHANGES IN BLOOD FLOW IN ESSENTIAL HYPERTENSIVE PATIENTS
Frederic Roca, Michele Iacob, Guillaume Feugray, Christian Thuillez, Jeremy Bellien, Robinson Joannides
Pages: 77 - 78
Background: Arterial wall viscosity (AWV) is a major source of cardiac energy dissipation along the arterial tree. Evolution of AWV during increase in blood flow and the impact of essential hypertension on this evolution have never been studied.
Methods: Radial artery diameter, wall thickness and arterial...
Conference Abstract
115. 12.6 THE ROLE OF NEURONAL NITRIC OXIDE SYNTHASE IN YOUNG ADULTS
Jessica Middlemiss, Sarah Evans, Joseph Cheriyan, Lucy Yang, Ian Wilkinson, Carmel McEniery
Pages: 78 - 78
Background: Early elevation in blood pressure are characterised by a hyperkinetic circulation, with an elevated cardiac index (CI) being the dominant feature. Neuronal NOS is a key regulator of vascular tone during mental stress and is attenuated in patients with established hypertension. However, the...
Conference Abstract
116. 12.7 THE RELATIONSHIP BETWEEN FUNCTIONAL ARTERIAL RESPONSE AND CIRCULATING BIOMARKERS OF PATIENTS WITH FIBROMUSCULAR DYSPLASIA
Thi-Phuong-Nhung Hoang, Pierre Boutouyrie, Hakim Hettab, Louise Marais, Aurelien Lorthioir, Michael Frank, Ralph Niarra, Jean-Marie Renard, Yann Chambon, Xavier Jeunemaitre, Pierre-François Plouin, Stéphane Laurent, Chantal Boulanger, Michel Azizi
Pages: 78 - 78
Background: Fibromuscular dysplasia (FMD) is a rare idiopathic, non-atherosclerotic non-inflammatory vascular disease. This work represents the first study of the pathophysiology of FMD. We investigated the relationships between circulating biomarkers and the non-invasive vascular parameters.
Methods:...
Conference Abstract
117. 12.8 VENTRICULAR-ARTERIAL UNCOUPLING DOES NOT DEPEND ON ARTERIAL ELASTANCE AFTER MYOCARDIAL INFARCTION
Elena Zharikova, Svetlana Villevalde, Zhanna Kobalava
Pages: 78 - 79
Objective: Ventricular remodeling may occur following myocardial infarction (MI) of the left ventricle (LV) and such remodeling has been shown to be correlated with increased patient morbidity and mortality. It is important to estimate the likelihood of remodeling from the state of the infarcted LV....
Conference Abstract
118. 12.9 VENTRICULAR ARTERIAL COUPLING IN ISOMETRIC HANDGRIP TEST IN UNTREATED HYPERTENSIVE PATIENTS
Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Pages: 79 - 79
Aim: To evaluate cardiovascular adaptation to increased afterload during handgrip isometric exercise (HIE) in untreated hypertensive patients.
Methods: 75 untreated hypertensive patients (age 54±7years, 44 males, BP 153/93 mmHg) underwent simultaneous EchoCG and blood pressure (BP) acquisition at rest...
Conference Abstract
119. 12.10 REDUCED VENTRICULAR-ARTERIAL COUPLING AS AN EARLY MARKER OF CARDIOVASCULAR REMODELING IN HYPERTENSIVE MEN
Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Pages: 79 - 79
Objective: To evaluate ventricular-arterial coupling (VAC), left ventricular hypertrophy (LVH), diastolic function and arterial stiffness in young and middle-aged men with uncomplicated arterial hypertension
Methods: 97 young men aged 18–27 years (21,2±1,9 years, BP 156,5±14,0/98,5±9,1 mmHg) and 68...
Conference Abstract
120. 12.11 SARCOPENIA AND VASCULAR RISK IN A HEALTHY ELDERLY UK POPULATION (BRAVES STUDY)
A. Nagy, I. Ramsay, J. Wright, C. Morrison, C. Bulpitt, F. Fantin, M. Zamboni, C. Rajkumar
Pages: 79 - 79
Introduction: Sarcopenia, the loss of skeletal muscle mass and strength that occurs with advancing age [1] is correlated with functional decline and disability but little is known about its relationship with cardiovascular risk. Bioimpedence analysis (BIA) is a validated technique for measuring muscle...
Conference Abstract
121. 13.1 THE EFFECTS OF ALPHA 1-ADRENOCEPTOR-BLOCKADE AND ANGIOTENSIN CONVERTING ENZYME-INHIBITION ON INDICES OF AORTIC STIFFNESS MEASURED BY AN OSCILLOMETRIC SINGLE CUFF METHOD IN HYPERTENSION: THE DOXAZOSIN RAMIPRIL STUDY
Andreas Jekell, Majid Kalani, Thomas Kahan
Pages: 79 - 80
Objectives: To study whether inhibition of the renin-angiotensin-aldosterone system has effects on arterial stiffness beyond blood pressure (BP) reduction alone.
Methods: Hypertensive patients (age 54±12 years, 34% women) were randomized double-blind to ramipril (10 mg od, n=32) or doxazosin (8 mg od,...
Conference Abstract
122. 13.2 EFFECTS ON VASCULAR STRUCTURE AND FUNCTION OF SINGLE AT1R BLOCKADE OR ITS COMBINATION WITH CCB, DIURETICS OR THEIR TRIPLE ASSOCIATION
Pedro Forcada, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon
Pages: 80 - 80
Conference Abstract
123. 13.3 SACUBITRIL/VALSARTAN THERAPY IS ASSOCIATED WITH DECREASE OF ARTERIAL ELASTANCE IN STABLE PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Zhanna Kobalava, Svetlana Villevalde, Olga Lukina, Evgenii Tyukhmenev
Pages: 80 - 80
Conference Abstract
124. 13.4 SACUBITRIL/VALSARTAN THERAPY IS ASSOCIATED WITH DECREASE OF PULSE WAVE VELOCITY IN STABLE PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
Zhanna Kobalava, Svetlana Villevalde, Olga Lukina
Pages: 80 - 80
Conference Abstract
125. 13.5 VENTRICULAR-ARTERIAL COUPLING DURING TREATMENT WITH BISOPROLOL AND BISIPROLOL/AMLODIPIN IN HYPERTENSIVE PATIENTS
Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Pages: 81 - 81
Conference Abstract
126. 13.6 SWITCHING TO BISOPROLOL/AMLODIPINE FDC ELIMINATES ADVERSE EFFECT OF A BETA-BLOCKER ON AORTIC PULSE PRESSURE AUGMENTATION
Anna Bogomaz, Yulia Kotovskaya, Zhanna Kobalava
Pages: 81 - 81
Conference Abstract
127. 13.7 RENAL DENERVATION IN TREATMENT RESISTANT HYPERTENSION: EFFECTS ON CORONARY FLOW RESERVE AND FOREARM DILATION CAPACITY. A RANDOMIZED, DOUBLE-BLINDED, SHAM-CONTROLLED CLINICAL TRIAL
Morten Engholm, Jannik B. Bertelsen, Ole N. Mathiassen, Henrik Vase, Jesper N. Bech, Anne P. Schroeder, Ole Lederballe, Hans Rickers, Christian D. Peters, Ulla Kampmannf, Per L. Poulsen, Sten Langfeldt, Gratien Andersen, Klavs W. Hansen, Erling B. Pedersen, Jens F. Lassen, Hans E. Boetker, Niels H. Buus, Anne Kaltoft, Kent L. Christensen
Pages: 81 - 81
Conference Abstract
128. 13.8 VENTRICULO-VASCULAR INTERACTIONS AND THE ARTERIAL WINDKESSEL: NEW INSIGHTS FROM CARDIOVASCULAR MAGNETIC RESONANCE IMAGING BEFORE AND AFTER RENAL DENERVATION
Giovanni Biglino, Amy Burchell, Jonathan Rodrigues, Robert D.M. Gray, Emma C. Hart, Julian F.R. Paton, Nathan E. Manghat, Andreas Baumbach, Angus K. Nightingale
Pages: 81 - 82
Conference Abstract
129. 13.9 THE EFFECT OF ROSUVASTATIN ADDED TO A STANDARD ANTIHYPERTENSIVE THERAPY ON ARTERIAL STIFFNESS IN PATIENTS WITH UNCONTROLLED HYPERTENSION
Anna Torunova
Pages: 82 - 82
Conference Abstract
130. 13.10 IMPACT OF THE GLYCEMIC CONTROL STATUS ON THE 2-YEAR PROGRESSION OF THE ARTERIAL STIFFNESS IN ADD-ON A DIPEPTIDYL PEPTIDASE 4 INHIBITOR TREATMENT
Hirofumi Tomiyama, Koichi Node, Akira Yamashina
Pages: 82 - 82
Conference Abstract
131. 13.11 EFFECTS OF DAPAGLIFLOZIN ON EARLY ALTERATIONS OF THE MICRO- AND MACROCIRCULATION
Christian Ott, Iris Kistner, Agnes Jumar, Stephanie Friedrich, Peter Bramlage, Roland Schmieder
Pages: 82 - 82
Conference Abstract
132. 14.1 MECHANISM OF AGE-RELATED INCREASES IN PULSE PRESSURE: LONGITUDINAL FOLLOW-UP OF THE TWINS UK COHORT
Ye Li, Benyu Jiang, Louise Keehn, Tim Spector, Phil Chowienczyk
Pages: 82 - 83
Conference Abstract
133. 14.2 LONGITUDINAL CHANGE IN VASCULAR STRUCTURE AND FUNCTION OVER A 5 YEAR PERIOD IN TWINS UK COHORT
Marina Cecelja, Benyu Jiang, Tim Spector, Phil Chowienczyk
Pages: 83 - 83
Conference Abstract
134. 14.3 IDEAL CARDIOVASCULAR HEALTH IS INVERSELY ASSOCIATED WITH INCREASED CAROTID-FEMORAL PULSE WAVE VELOCITY IN ITALIAN ADOLESCENTS. THE MACISTE STUDY
Giacomo Pucci, Francesca Battista, Marco D’Abbondanza, Leandro Sanesi, Giuseppe Schillaci
Pages: 83 - 83
Conference Abstract
135. 14.4 A POSITIVE FAMILY HISTORY OF DIABETES IS ASSOCIATED WITH ARTERIAL STIFFNESS: THE MALMO DIET CANCER STUDY
Mikael Gottsater, Peter Nilsson
Pages: 83 - 83
Conference Abstract
136. 14.5 LEVELS OF ANGIOPOIETIN-LIKE-2 ARE POSITIVELY ASSOCIATED WITH AORTIC STIFFNESS AND MORTALITY AFTER KIDNEY TRANSPLANTATION
Marie-Pier Desjardins, Nathalie Thorin-Trescases, Aboubacar Sidibe, Sacha De Serres, Richard Larivière, Eric Thorin, Mohsen Agharazii
Pages: 83 - 84
Conference Abstract
137. 14.6 RELATIONSHIP BETWEEN 24-HOUR BLOOD PRESSURE VARIABILITY AND 24-HOUR CENTRAL ARTERIAL PRESSURE, PULSE WAVE REFLECTION AND STIFFNESS IN HYPERTENSIVE PATIENTS
Stefano Omboni, Igor Posokhov, Anatoly Rogoza
Pages: 84 - 84
Conference Abstract
138. 14.7 HYALURONAN IS ASSOCIATED WITH AORTIC STIFFENING IN HEALTHY SUBJECTS
Kaisa Maki-Petaja, Kimberley Chan, Carmel McEniery, Ian Wilkinson
Pages: 84 - 84
Conference Abstract
139. 14.8 VASCULAR ABNORMALITIES RELATED WITH OBESITY
Pedro Forcada, Carlos Castellaro, Jorge Chiabaut, Sergio Gonzalez, Carol Kotliar, Sebastian Obregon
Pages: 84 - 84
Conference Abstract
140. 14.9 INCREASED ARTERIAL STIFFNESS PREDICTS LESS RECOVERY OF LEFT VENTRICULAR SYSTOLIC FUNCTION AFTER MYOCARDIAL INFARCTION
Elena Zharikova, Svetlana Villevalde, Zhanna Kobalava
Pages: 84 - 85
Conference Abstract
141. 14.10 INCREASED CENTRAL PRESSURE AUGMENTATION IS ASSOCIATED WITH REDUCED SLEEP DURATION IN INDIVIDUALS EXPOSED TO AIRCRAFT NOISE POLLUTION: THE SERA-CV STUDY
Rosa Maria Bruno, Ugo Faraguna, Enrica Bonanni, Marina Di Pilla, Marco Di Galante, Tommaso Banfi, Angelo Gemignani, Gaetano Licitra, Francesco Fidecaro, Stefano Berrettini, Maria Angela Vigotti, Stefano Taddei, Lorenzo Ghiadoni
Pages: 85 - 85
Conference Abstract
142. 14.11 TOTAL ARTERIAL COMPLIANCE AS A RISK FACTOR FOR ORGAN DAMAGE IN HYPERTENSION
Dimitrios Terentes-Printzios, Charalambos Vlachopoulos, Nikolaos Ioakeimidis, Panagiota Pietri, Panagiotis Xaplanteris, Eleftherios Paschalidis, Nikitas Skliros, Dimitrios Tousoulis
Pages: 85 - 86
Conference Abstract
143. 15.1 ANALYSIS OF THREE STATISTICAL METHODS TO PREDICT THE PRESENCE OF CAROTID ATHEROMATOUS PLAQUES
Daniel Schang, Mathieu Feuilloy, Magid Hallab, Mathieu Collette, Georges Leftheriotis
Pages: 85 - 86
Background: At least 15–20% of all ischemic strokes are attributable to atherosclerosis [1]. We analyzed three statistical methods for 12 traditional risk factors (TRF) i.e. age, sex, arterial pressure, Intima Media Tickness (IMT), Pulse Wave Velocity (PWV) in order to predict the presence of carotid...
Conference Abstract
144. 15.2 ESTIMATES OF ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN PATIENTS WITH TYPE 2 DIABETES: A COMPARISON OF SPHYGMOCOR AND ARTERIOGRAPH
Christoffer Krogager, Niklas B. Rossen, Klavs W. Hansen, Søren T. Knudsen, Christian D. Peters, Hans Erik Bøtker, Per L. Poulsen, Esben Laugesen
Pages: 86 - 86
Conference Abstract
145. 15.3 ARTERIAL STIFFNESS RECORDINGS WITH POPMÈTRE® IN A GENERAL PRIMARY CARE POPULATION: THE IPC COHORT
Hasan Obeid, Frederique Thomas, Pierre Boutouyrie, Magid Hallab, Philippe Coucke, Nicolas Danchin, Bruno Pannier
Pages: 86 - 86
Conference Abstract
146. 15.4 MEASURING ARTERIAL STIFFNESS WITH POPMÈTRE® IN CARDIAC REHABILITATION PROGRAM
Hasan Obeid, Bruno Pavy, Magid Hallab, Julie Darchis, Erick Merle
Pages: 86 - 86
Conference Abstract
147. 15.5 ASSOCIATION OF A NEW SURROGATE OF TOTAL ARTERIAL COMPLIANCE WITH LEFT VENTRICULAR MASS: THE SAFAR STUDY
Theodore Papaioannou, Athanase Protogerou, Antonis Argyris, Evangelia Aissopou, Eftymia Nasothymiou, Christos Tountas, Petros Sfikakis, Nikolaos Stergiopulos, Dimitrios Tousoulis
Pages: 86 - 87
Conference Abstract
148. 15.6 INFLUENCE OF THE PRESSURE MEASURING SITE FOR VELOCITY/PRESSURE LOOPS
Jona Joachim, Fabrice Vallée, Arthur Le Gall, Stéphanie Lenck, Alexandre Mebazaa, Étienne Gayat
Pages: 87 - 87
Conference Abstract
149. 15.7 STUDY OF WAVE DYNAMICS OF AN EXTRA-AORTIC COUNTERPULSATION DEVICE IN A ONE-DIMENSIONAL COMPUTER MODEL OF THE ARTERIAL SYSTEM
Daime Campos Arias, Francisco Londono, Tania Rodriguez Moliner, Dimitrios Georgakopoulos, Nikos Stergiopulos, Patrick Segers
Pages: 87 - 87
Conference Abstract
150. 15.8 AN EXTENDED ONE-DIMENSIONAL ARTERIAL NETWORK MODEL FOR THE SIMULATION OF PRESSURE AND FLOW IN UPPER AND LOWER LIMB EXTREMITIES
Hasan Obeid, Patrick Segers, Nikos Stergiopulos, Pierre Boutouyrie, Stephane Laurent, Magid Hallab, Elie Mousseaux
Pages: 87 - 88
Conference Abstract
151. 15.9 MODELLING ARTERIAL PULSE PRESSURE FROM HEART RATE DURING SYMPATHETIC ACTIVATION
Bjorn van der Ster, Berend Westerhof, Wim Stok, Feras Hatib, Jos Settels, Johannes van Lieshout
Pages: 88 - 88
Conference Abstract
152. 15.10 FORM FACTOR OF THE FEMORAL ARTERY: AN INVASIVE STUDY
Mathieu Jozwiak, Sandrine Millasseau, Xavier Monnet, Francois Depret, Jean-Emmanuel Alphonsine, Nathalie Richard, Pierre Attal, Jean-Louis Teboul, Denis Chemla
Pages: 88 - 88
Conference Abstract
153. 15.11 TOWARDS NONINVASIVE CARDIAC CATHETERISATION
Maarten Heusinkveld, Joost Lumens, Katherine March, Arthur Bouwman, Tammo Delhaas, Alun Hughes, Koen Reesink
Pages: 88 - 88
Conference Abstract
154. PO-01 ANIMAL MODELS OF LOCAL AORTIC STIFFENING: THE EFFECT OF SALT IN SHRSP
George Lindesay, Christophe Ragonnet, Nicole Villeneuve, Christine Vayssettes-Courchay
Pages: 89 - 89
Conference Abstract
155. PO-02 NO SEX DIFFERENCES IN THE CARDIOVASCULAR RESPONSE TO MENTAL-STRESS IN OLDER ADULTS
Wesley K. Lefferts, Jacqueline A. Augustine, Kayla M. Nunemacher, Kevin S. Heffernan
Pages: 89 - 90
Conference Abstract
156. PO-03 IMPROVEMENT IN POST-TRANSPLANT HYPERTENSION IN LIVING DONOR RENAL TRANSPLANTATION
Ekamol Tantisattamo, Weera Sukhumthammarat, Prapaipan Putthapiban, Wasawat Vutthikraivit, Siwadon Pitukweerakul
Pages: 90 - 90
Objectives: Since genetic factor determines part of hypertensive phenotype, we aim to demonstrate the role of transplanted kidney from normotensive living donors in post-transplant hypertension (HTN).
Methods: From 1.5-year-medical record review yielded 103 kidney transplant recipients in whom living-donor...
Conference Abstract
157. PO-04 REBOUND WEIGHT GAIN AND BLOOD PRESSURE CONTROL AFTER LIVING KIDNEY DONATION AND KIDNEY TRANSPLANTATION
Ekamol Tantisattamo, Weera Sukhumthammarat, Prapaipan Putthapiban, Wasawat Vutthikraivit, Siwadon Pitukweerakul
Pages: 90 - 91
Objective: Overweight and obesity are known risk factors of hypertension in both donors and recipients after kidney donation and transplantation, respectively. We aim to study the correlation between blood pressure (BP) and body mass index (BMI) in donor post-donation and in recipients post-transplantation.
Methods:...
Conference Abstract
158. PO-09 CENTRAL HEMODYNAMICS AND ARTERIAL STIFFNESS IN YOUNG OBESE ADULTS: THE PRELIMINARY FINDING
K. Bunsawat, G. Grigoriadis, T. Hilgenkamp, B. Fernhall, T. Baynard
Pages: 91 - 91
Changes in central hemodynamics and arterial stiffness are associated with augmented cardiovascular risks and have been reported in obese adults with metabolic syndrome. It is unclear whether this observation may also be present in young healthy obese adults with normal metabolic profile.
Objectives:...
Conference Abstract
159. PO-10 VASCULAR FUNCTION IN INDIVIDUALS WITH DOWN SYNDROME
Sang Ouk Wee, Alexander J. Rosenberg, Kanokwan Bunsawat, Garett Griffith, Tracy Baynard, Bo Fernhall
Pages: 91 - 92
Individuals with Down syndrome (DS) experience premature aging. Arterial stiffness increases with advancing biological age and predicts cardiovascular disease. However, only limited studies investigated arterial function in individuals with DS. Thus, the impact of DS on vascular function still remains...
Conference Abstract
160. PO-11 MULTIPLE SCLEROSIS PATIENTS EXPERIENCE MORE DECREMENTS IN CAROTID ARTERY FUNCTIONAL PROPERTIES WITH AGING THAN AGE-MATCHED PEERS
Garett Griffith, Thessa Hilgenkamp, Rachel E. Klaren, Sang Ouk Wee, Robert W. Motl, Tracy Baynard, Bo Fernhall
Pages: 92 - 92
Introduction: Peak prevalence of multiple sclerosis (MS) is approaching 60 years of age, suggesting an aging patient population compared to past reports. Aging is independently associated with increased cardiovascular disease risk. Additionally, arterial function is compromised with aging. Carotid artery...
Conference Abstract
161. PO-12 RELATIONS BETWEEN AORTIC STIFFNESS AND LEFT VENTRICULAR MECHANICAL FUNCTION
Vanessa C. Bell, Elizabeth L. McCabe, Martin G. Larson, Jian Rong, Allison A. Merz, Ewa Osypiuk, Birgitta T. Lehman, Plamen Stantchev, Jayashri Aragam, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan, Gary F. Mitchell, Susan Cheng
Pages: 92 - 92
Objectives: Left ventricular contraction produces longitudinal strain in the proximal aorta. As a result, aortic stiffening may impair optimal mechanical ventricular-vascular coupling and left ventricular (LV) systolic function, particularly in the long axis. LV global longitudinal strain (GLS) has recently...
Conference Abstract
162. PO-13 SEX DIFFERENCES IN VASCULAR FUNCTION FOLLOWING ANTIOXIDANT SUPPLEMENTATION
R.M. Kappus, K. Bunsawat, J.M. Haus, T. Baynard, S.A. Phillips, M.D. Brown, B. Fernhall
Pages: 93 - 93
Objectives: Sex differences in cardiovascular disease risk and progression are well established. Estrogen loss following menopause leads to vascular dysfunction, potentially due to elevations in oxidative stress and subsequent decrements in nitric oxide. It is possible a reduction in oxidative stress...
Conference Abstract
163. PO-14 PULSE WAVE VELOCITY IS INCREASED WITH EXPERIMENTAL SLEEP RESTRICTION IN HEALTHY HUMANS
Jacqueline K. Limberg, Naima Covassin, Michael J. Joyner, Virend K. Somers
Pages: 93 - 93
Objectives: Increased carotid-femoral pulse wave velocity is indicative of vascular stiffening of the central arterial tree. Aortic stiffness is a key risk factor for the development of hypertension and cardiovascular disease. Following acute (24-hour) sleep deprivation, healthy adults exhibit an increase...
Conference Abstract
164. PO-16 BLOOD PRESSURE VARIABILITY AND BARORECEPTOR SENSITIVITY IN NORMOTENSIVE OBESE IN RESPONSE TO AEROBIC EXERCISE
Georgios Grigoriadis, Kanokwan Bunsawat, Bo Fernhall, Tracy Baynard
Pages: 93 - 94
Background: Autonomic dysfunction, with increased sympathetic activity at rest has been reported in obese individuals. Indices of blood pressure variability (BPV) and baroreceptor sensitivity (BRS) can provide insight into aspects of autonomic function, particularly following an aerobic exercise bout.
Purpose:...
Conference Abstract
165. PO-17 ROLE OF NITRIC OXIDE IN β2-ADRENERGIC MEDIATED VASODILATION IN POSTMENOPAUSAL WOMEN
Sushant M. Ranadive, Roneé E. Harvey, Jacqueline K. Limberg, Timothy B. Curry, Wayne T. Nicholson, Michael J. Joyner
Pages: 94 - 94
Objectives: Postmenopausal (PM) women have a blunted β2-adrenergic receptor-mediated responsiveness when compared to young premenopausal women in part due to a reduction in the relative contribution of nitric oxide (NO) to β2-adrenergic mediated vasodilation. Hence, we tested the contribution of NO to...
Conference Abstract
166. PO-19 ASSOCIATIONS OF WALKING WITH SARCOPENIC OBESITY AND CARDIOVASCULAR DISEASE RISK FACTORS IN OLDER ADULTS
Duck-chul Lee, Nathan F. Meier, Esmée Bakker
Pages: 94 - 94
Objectives: To investigate the associations of walking (steps/day) with sarcopenic obesity (SO) and cardiovascular disease (CVD) risk factors in older adults.
Methods: This cross-sectional study included 297 older adults aged ≥65 years (mean age 72, ranged 65–95). Walking was assessed using an accelerometer...
Conference Abstract
167. PO-20 A HYDROGEN SULFIDE PRODRUG AUGMENTS ANGIOGENESIS IN A SWINE MODEL OF CRITICAL LIMB ISCHEMIA VIA A NITRIC OXIDE DEPENDENT MECHANISM
Amanda M. Rushing, Amy L. Scarborough, Sarah F. Boisvert, Erminia Donnarumma, Rishi Trivedi, David J. Polhemus, David J. Lefer, Traci T. Goodchild
Pages: 94 - 95
Introduction: Despite advances in revascularization, treatments for critical limb ischemia (CLI) have been largely unsuccessful. Hydrogen sulfide (H2S) and nitric oxide (NO), are endogenous gasotransmitters which exert potent vasodilatory and proangiogenic effects. Recent experimental evidence suggest...
Conference Abstract
168. PO-22 BODY MASS INDEX AS AN INDEPENDENT PREDICTOR OF CHANGE IN ARTERIAL STIFFNESS PARAMETERS WITH CHANGE IN BODY POSITION
Elizabeth C. Schroeder, Thessa I.M. Hilgenkamp, Alexander J. Rosenberg, Daniel W. White, Tracy Baynard, Bo Fernhall
Pages: 95 - 95
Changing from supine to a seated position creates an orthostatic challenge due to the effects of gravity on the distribution of blood. This redistribution of volume unloads baroreceptors and may evoke sympathetic activation. The sympathetic activation may lead to increases in arterial stiffness, but...
Conference Abstract
169. PO-23 A SYSTEMATIC REVIEW ON THE EFFECT OF ACUTE AEROBIC EXERCISE ON ARTERIAL STIFFNESS REVEALS A DIFFERENTIAL RESPONSE IN THE UPPER AND LOWER ARTERIAL SEGMENTS
Alexandra B. Cooke, Andrew F. Mutter, Oliver Saleh, Yessica-Haydee Gomez, Stella S. Daskalopoulou
Pages: 95 - 95
Objectives: The overall impact of resistance-type exercises and chronic physical activity on the modulation of arterial stiffness has been well characterized; however, the impact of acute aerobic exercise remains unclear. Therefore, we aimed to synthesize evidence pertaining to acute changes in arterial...
Conference Abstract
170. PO-24 RELATIONSHIP BETWEEN STEP COUNTS AND CAROTID FEMORAL PULSE WAVE VELOCITY IN ADULTS TREATED FOR HYPERTENSION AND DIABETES
Kaberi Dasgupta, Alexandra B. Cooke, Ellen Rosenberg, Lawrence Joseph, Stella S. Daskalopoulou
Pages: 95 - 96
Objectives: ‘Step counts’ captured by wearable physical activity tracking devices are associated with reductions in cardiovascular disease. However, in individuals on cardioprotective medications the impact of step counts may not be captured by the measurement of traditional cardiometabolic risk factors....
Conference Abstract
171. PO-25 HIGHER CENTRAL AND BRACHIAL SYSTOLIC BLOOD PRESSURE IS SELECTIVELY ASSOCIATED WITH WEAKER COGNTIVE PERFORMANCE IN POSTMENOPAUSAL WOMEN BUT NOT OLDER MEN
lyndsey E. Dubose, David J. Moser, Taylor Stecklein, Emily Harlynn, William G. Haynes, Gary L. Pierce
Pages: 96 - 96
Introduction: Higher aortic stiffness and central blood pressure (BP) are associated with reduced cognitive performance in older adults. Cognitive performance tends to be higher in older women compared with older men, unexplained by differences in years of formal education and/or presence of atherosclerotic...
Conference Abstract
172. PO-26 BILATERAL SYMMETRY OF BRACHIAL PULSE WAVEFORM ANALYSIS IN A CLINICAL POPULATION
Jumana Dakka, Timothy S. Phan, Izzah Vasim, Swapna Varakantam, Uzma Kewan, Ali Tariq, Harry G. Oldland, Amer Ahmed Syed, Zeba Hashmath, Scott R. Akers, Julio A. Chirinos
Pages: 96 - 97
Background: Pulse waveforms are modified as they propagate along the arterial tree. Small differences in the arterial pathways from the heart to the left and right brachial artery may impact pulse waveform analysis (PWA) for the purpose of hemodynamic assessment. The VaSera VS-1500AU (Fukuda Denshi)...
Conference Abstract
173. PO-27 A NEW SOFTWARE FOR DETERMINING CHANGES IN ARTERIAL DIAMETER OVER TIME
Ka Zuj, J. Deglint, A. Gawish, A. Wong, D.A. Clausi, R.L. Hughson
Pages: 97 - 97
Objectives: The purpose was to investigate the ability of a new software, developed by our group, to provide continuous measures of arterial diameter from recorded ultrasound video.
Methods: Software (MAUI) was developed to assess arterial diameter using active contours to accurately detect the vessel...
Conference Abstract
174. PO-30 EFFECT OF LOW-DOSE ACETYLSALICYLIC ACID ON ARTERIAL STIFFNESS IN HIGH-RISK PREGNANCIES: AN OBSERVATIONAL LONGITUDINAL STUDY
Kim Phan, Yessica-Haydee Gomez, Amira El-Messidi, Robert Gagnon, Stella S. Daskalopoulou
Pages: 97 - 97
Objectives: Low-dose acetylsalicylic acid (ASA) has been shown to reduce the risk for pre-eclampsia in high-risk pregnancies when prescribed before 16 weeks of gestation. It remains unknown whether this anti-inflammatory agent has effects on arterial stiffness. Our objective was to characterize arterial...
Conference Abstract
175. PO-31 EFFECT OF POOR GLYCEMIC CONTROL ON ARTERIAL STIFFNESS IN PREGNANCY
Kim Phan, Yessica-Haydee Gomez, Mohamed Salah Al-azzawi, Amira El-Messidi, Stella S. Daskalopoulou
Pages: 97 - 97
Objectives: Poor glycemic control during pregnancy is associated with increased adverse perinatal outcomes. Our objective was to characterize the association between glycemic control and arterial stiffness in pregnancy.
Methods: In this prospective longitudinal study, women with high-risk singleton...
Conference Abstract
176. PO-32 DIETARY CALCIUM INTAKE AND CARDIOVASCULAR HEALTH: IS THERE ANY RELATIONSHIP?
Shubhabrata Das, Yessica-Haydee Gomez, David Goltzman, Angel M. Ong, Yessica H. Gomez, Jessica Gorgui, Michelle Wall, Suzanne N. Morin, Stella S. Daskalopoulou
Pages: 97 - 98
Introduction: Calcium intake, recommended for osteoporosis prevention, has been associated with cardiovascular (CV) outcomes. We examined the association of dietary calcium intake (dCa) with surrogate CV markers, including carotid intima-media thickness (cIMT), arterial stiffness and hemodynamics in...
Conference Abstract
177. PO-33 STATIN THERAPY IN RHEUMATOID ARTHRITIS MAY IMPROVE ARTERIAL STIFFNESS IN WOMEN BUT NOT IN MEN: A PRELIMINARY ANALYSIS
Yessica-Haydee Gomez, Shubhabrata Das, Jessica Gorgui, Ines Colmegna, Stella S. Daskalopoulou
Pages: 98 - 98
Objectives: Patients with rheumatoid arthritis are at increased risk for cardiovascular disease. Statins have anti-inflammatory and immunomodulatory effects, thereby reducing cardiovascular risk. Arterial stiffness is a composite indicator of cardiovascular health and a predictor of cardiovascular risk....
Conference Abstract
178. PO-35 FIRST IN MAN MEASUREMENT OF ARTERIAL STIFFNESS USING A CONNECTED BATHROOM SCALE: CALIBRATION AGAINST SPHYGMOCOR
Pierre Boutouyrie, Hakim Khettab, David Campo, Roger Yu, Nadine Buard
Pages: 98 - 98
Background: Measurement of arterial stiffness (AS) is still considered difficult. We developed a non- invasive technique to assess AS from a connected bathroom scale, based on ballistocardiography (BCG) and impedance plethysmography (IPG).
Methods: We included 192 subjects and patients, 106 for calibration...
Conference Abstract
179. PO-36 EFFECTS OF FIXED VERSUS AUTO-TITRATING CONTINUOUS POSITIVE AIRWAY PRESSURE ON VASCULAR FUNCTION IN PATIENTS WITH RESISTANT HYPERTENSION AND OBSTRUCTIVE SLEEP APNEA
Karen Tran, R.J. Kimoff, S.S. Daskalopoulou
Pages: 98 - 99
Introduction: Obstructive sleep apnea (OSA) is a common cause of resistant hypertension. We investigated the effects of 2 modalities of positive airway pressure; fixed continuous airway pressure (fCPAP) versus auto-titrating positive airway pressure (APAP) on arterial function in subjects with resistant...
Conference Abstract
180. PO-37 THE IMPACT OF INTRADIALYTIC PEDALING EXERCISE ON ARTERIAL STIFFNESS IN A HEMODIALYSIS POPULATION
Alexandra B. Cooke, Vincent Ta, Yessica-Haydee Gomez, Sameena Iqbal, Stella S. Daskalopoulou
Pages: 99 - 100
Objectives: Hemodialysis patients are at greater risk of increased arterial stiffness. Regular aerobic exercise has been shown to reduce arterial stiffness in hemodialysis patients. However, the impact of a more realistic intradialytic form of exercise, such as pedaling, is unclear. Therefore, we aimed...
Conference Abstract
181. OR-04 DECREASED AORTIC INERTANCE INCREASES SUSCEPTIBILITY OF LATE-SYSTOLIC LEFT VENTRICULAR EJECTION TO ARTERIAL WAVE REFLECTIONS
Timothy S. Phan, John K.-J. Li, Amer Ahmed Syed, Harry G. Oldland, Uzma Kewan, Scott R. Akers, Julio A. Chirinos
Pages: 102 - 102
Background: Left ventricular (LV) afterload patterns consisting of late-systolic loading has been linked to LV remodeling and fibrosis in a number of studies. The contributions from arterial wave reflections (WR) has therefore garnered much interest. Aortic dilation may facilitate the adverse effects...
Conference Abstract
182. OR-02 EFFECT OF ACUTE ISOKINETIC RESISTANCE EXERCISE ON SYSTEMIC ARTERIAL HEMODYNAMICS AND CEREBRAL BLOOD FLOW DYNAMICS: IS THERE A MISMATCH?
A. Rosenberg, S.O. Wee, E. Schroeder, K. Bunsawat, G. Grigoriadis, B. Fernhall, T. Baynard
Pages: 101 - 102
Resistance exercise (RE) is currently recommended for most adults and is important for reducing risk factors for cardiovascular and metabolic diseases, and improving quality of life. Despite functional and musculoskeletal benefits, high-intensity RE has been shown to acutely increase arterial stiffness...
Conference Abstract
183. OR-05 SEX DIFFERENCES IN VASCULAR STRUCTURE AND FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS AND HEALTHY CONTROLS
Thessa Hilgenkamp, Garett Griffith, Robert W. Motl, Tracy Baynard, Bo Fernhall
Pages: 102 - 103
Objectives: Cardiovascular disease is a leading cause of death in multiple sclerosis (MS), and recent data showed that subclinical markers of atherosclerosis are higher in MS as well. Prevalence of MS in men is much lower than in women, but their prognosis is much worse. Men with MS also have higher...