3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION

Junjing Su; Charlotte Manisty; Kim H. Parker; Soren Mellemkjaer; Luke Howard; Ulf Simonsen; Alun Hughes

doi:10.1016/j.artres.2016.10.014

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Volume 16, Issue C, December 2016, Pages 51 - 52

3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION

Authors

Junjing Su¹, Charlotte Manisty², Kim H. Parker³, Soren Mellemkjaer⁴, Luke Howard⁵, Ulf Simonsen¹, Alun Hughes²

¹Department of Biomedicine, Aarhus University, Denmark

²Institute of Cardiovascular Science, University College London, UK

³Department of Bioengineering, Imperial College London, UK

⁴Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark

⁵National Heart and Lung Institute, Imperial College London, UK

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.014 How to use a DOI?
Abstract: Background: The objective of the study was to apply wave intensity analysis (WIA) in the pulmonary artery to characterise the magnitude, origin, type and timing of arterial waves in individuals with and without pulmonary hypertension (PH).

Methods: Right heart catheterisation was performed using a pressure and Doppler flow sensor tipped catheter to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery. WIA was applied to the acquired data (1).

Results: In controls (n = 10), the wave speed in the pulmonary artery was 3.03 m/s (2.69 – 3.91 m/s) and this increased in pulmonary arterial hypertension (PAH, n = 11, 11.9 m/s [10.5 – 16.4 m/s]) and chronic thromboembolic pulmonary hypertension patients (CTEPH, n = 10, 15.1 m/s [11.5 – 16.8 m/s]). Wave intensity was significantly greater in PH patients compared to controls. Wave reflection index (WRI) was 3.81 % (3.58 – 6.24 %) in controls, 23.4 % (17.5 – 29.7 %) in PAH and 30.4 % (11.9 – 35.6 %) in CTEPH patients. WRI was not related to pulmonary vascular resistance or right ventricular fractional area change and patients with mildly and severely elevated pulmonary pressure had similar WRI.

Conclusions: Wave speed, wave intensity and wave reflection in the pulmonary artery was higher in PH patients indicating increased arterial stiffness, right ventricular work and vascular impedance mismatch, respectively. While WRI does not reflect the severity of PH in established disease, the presence of increased wave reflection could be a novel early marker of pulmonary vascular disease.
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.KH Parker, An introduction to wave intensity analysis, Med Biol Eng Comput, Vol. 47, 2009, pp. 175.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 51 - 52
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.014 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Junjing Su
AU  - Charlotte Manisty
AU  - Kim H. Parker
AU  - Soren Mellemkjaer
AU  - Luke Howard
AU  - Ulf Simonsen
AU  - Alun Hughes
PY  - 2016
DA  - 2016/11/24
TI  - 3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION
JO  - Artery Research
SP  - 51
EP  - 52
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.014
DO  - 10.1016/j.artres.2016.10.014
ID  - Su2016
ER  -

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