Artery Research

Volume 16, Issue C, December 2016, Pages 76 - 76

11.9 PARAMETERS OF ARTERIAL STIFFNESS HAVE INDEPENDENT PROGNOSTIC VALUE IN STABLE PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION

Authors
Evgeny Tyukhmenev, Svetlana Villevalde, Zhanna Kobalava
RUDN University, Moscow, Russia
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.097How to use a DOI?
Abstract

The purpose of the study was to determine the prognostic value of ventricular-arterial coupling (VAC) in patients with arterial hypertension (AH) and stable heart failure with reduced ejection fraction (HFrEF).

Methods: In prospective study (follow-up 12–24 months, median 18 months) prognosis of 93 stable patients with controlled hypertension and HFrEF was evaluated. Adverse outcomes included all cause death or first HF hospitalization. 2-dimentional echocardiography was used to assess arterial elastance (Ea) and end-systolicLV elastance (Ees). VAC was assessed as the ratio Ea/Ees. Arterial stiffness was assessed using applanation tonometry. Clinical and demographic parameters, parameters of LV function, VAC and arterial stiffness were included in multivariate analysis. P<0.05 was considered significant.

Results: Adverse outcomes were revealed in 39% of patients (15% deaths, 24% HF hospitalizations). The following factors increased the risk of adverse outcomes: LVEF <25%, index of VAC 33.3, stroke work (SW)/pressure volume area (PVA) (LV work efficiency) <38%, augmentation index (AI) ≥25%, time to reflected wave(Tr) <135. Pulse wave velocity ≥15 m/s, office systolic BP <120 mmHg were associated with increased risk of HF hospitalizations. AI >35%, office systolic BP <120 and diastolic BP <70, Tr <116, SW/PVA <48% were associated with increased risk of all-cause death.

Conclusions: Parameters of VAC and arterial stiffness have independent prognostic value as well as LVEF and BP in patients with AH and HFrEF. Assessment of VAC via Ea/Elv, an additional noninvasively derived metric, can be used for risk stratification of patients with HFrEF.

Open Access
This is an open access article distributed under the CC BY-NC license.

Journal
Artery Research
Volume-Issue
16 - C
Pages
76 - 76
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.097How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - JOUR
AU  - Evgeny Tyukhmenev
AU  - Svetlana Villevalde
AU  - Zhanna Kobalava
PY  - 2016
DA  - 2016/11/24
TI  - 11.9 PARAMETERS OF ARTERIAL STIFFNESS HAVE INDEPENDENT PROGNOSTIC VALUE IN STABLE PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.097
DO  - 10.1016/j.artres.2016.10.097
ID  - Tyukhmenev2016
ER  -