Artery Research

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Volume 16, Issue C, December 2016, Pages 64 - 64

7.9 CAROTID ARTERY STIFFNESS IS ASSOCIATED WITH CT-MEASURED LUNG AIR-TRAPPING IN COPD PATIENTS AND CONTROLS INDEPENDENT OF AGE, BLOOD PRESSURE AND SMOKING HISTORY

Authors
Gary Pierce, John Newell, Alejandro Comellas, Eric Hoffman, Kelsey Warner, Anna Croghan, Lyndsey DuBose, Peg Nopoulos, Vince Magnotta, Stephan Arndt, Karin Hoth
University of Iowa, Iowa City, USA
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.055How to use a DOI?
Abstract

Background: Early stages of chronic obstructive pulmonary disease (COPD) are characterized by loss of the terminal bronchioles and ‘air trapping’ often before overt emphysema manifests (1). COPD patients are also at risk for cardiovascular disease (CVD), therefore, we hypothesized that the degree of air trapping on computed tomography (CT) (2) would be associated with higher aortic (carotid femoral pulse wave velocity, CFPWV) and carotid artery stiffness (β-stiffness), biomarkers of CVD risk.

Methods: Ten adults with COPD but little emphysema (age 66±8 yrs, 5F/5M, GOLD stage 1–3) and 9 adults without COPD (age 59±13 yrs, 5F/4M) that had a research chest CT were recruited.

Results: COPD patients had greater smoking history (45.9 ± 21 vs. 6.4 ± 12.9 pack-years, P<0.001) and air trapping (0.85± 0.07 vs. 0.78 ±0.05 Expiration/Inspiration attenuation ratio, p<0.05) (2) compared with non-COPD subjects, but did not differ by age, BMI, SaO2%, brachial BP or % emphysema (all p>0.05). COPD patients had significantly higher CFPWV (999± 293 vs. 760 ±147 cm/sec, p<0.05) but not carotid β-stiffness (13.3± 5.1 vs. 10.6 ±4.7 U, p=0.26). In the entire cohort (n=19), air trapping was associated with higher CFPWV (r=0.60, p<0.01) and carotid β-stiffness (r=0.75, p<0.001). After adjustment for age, mean BP and pack-years, the correlation between carotid β-stiffness and air-trapping remained significant (r=0.68, p<0.01).

Conclusions: Carotid artery stiffness is significantly associated with air trapping in COPD patients and controls, independent of age, smoking history and BP. This suggests a link between high CVD risk in COPD patients with small airway disease without predominant emphysema.

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This is an open access article distributed under the CC BY-NC license.

References

1.JE McDonough, R Yuan, M Suzuki, N Seyednejad, WM Elliott, PG Sanchez, AC Wright, WB Gefter, L Litzky, HO Coxson, PD Paré, DD Sin, RA Pierce, JC Woods, AM McWilliams, JR Mayo, SC Lam, JD Cooper, and JC Hogg, Small-airway obstruction and emphysema in chronic obstructive pulmonary disease, N Engl J Med, Vol. 365, No. 17, 2011, pp. 1567-75.
2.CP Hersh, GR Washko, RS Estépar, S Lutz, PJ Friedman, MK Han, JE Hokanson, PF Judy, DA Lynch, BJ Make, N Marchetti, JD Newell Jr, FC Sciurba, JD Crapo, and EK Silverman, COPDGene Investigators, Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD, Respir Res, Vol. 14, 8 Apr 2013, pp. 42.
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Journal
Artery Research
Volume-Issue
16 - C
Pages
64 - 64
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.055How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Gary Pierce
AU  - John Newell
AU  - Alejandro Comellas
AU  - Eric Hoffman
AU  - Kelsey Warner
AU  - Anna Croghan
AU  - Lyndsey DuBose
AU  - Peg Nopoulos
AU  - Vince Magnotta
AU  - Stephan Arndt
AU  - Karin Hoth
PY  - 2016
DA  - 2016/11/24
TI  - 7.9 CAROTID ARTERY STIFFNESS IS ASSOCIATED WITH CT-MEASURED LUNG AIR-TRAPPING IN COPD PATIENTS AND CONTROLS INDEPENDENT OF AGE, BLOOD PRESSURE AND SMOKING HISTORY
JO  - Artery Research
SP  - 64
EP  - 64
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.055
DO  - 10.1016/j.artres.2016.10.055
ID  - Pierce2016
ER  -