7.10 AORTIC STIFFNESS AND BODY MASS INDEX (BMI) IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Nichola Gale; Ali Albarrati; Margaret Munnery; Dennis Shale; John Cockcroft

doi:10.1016/j.artres.2016.10.056

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Volume 16, Issue C, December 2016, Pages 64 - 65

7.10 AORTIC STIFFNESS AND BODY MASS INDEX (BMI) IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)

Authors

Nichola Gale¹, Ali Albarrati¹, Margaret Munnery², Dennis Shale³, John Cockcroft²

¹Cardiff University, Cardiff, UK

²Cardiff Metropolitan University, Cardiff, UK

³GSK, Uxbridge, UK

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.056 How to use a DOI?
Abstract: Background: Patients with COPD have increased Cardiovascular (CV) risk and commonly present with altered body composition. Patients with COPD and a low BMI have poorer health outcomes¹, while obesity may increase CV risk². The aim of this analysis was to explore BMI, CV risk, exercise capacity and systemic inflammation in COPD.

Methods: This analysis included 524 stable patients with COPD (confirmed with spirometry) from the ARCADE (Assessment of Risk in Chronic Airways Disease Evaluation) study. Assessments included lung function (forced expiratory volume in 1 second (FEV1)), smoking history, BMI, aortic pulse wave velocity (PWV) (SphygmoCor device), blood pressure (BP), 6-minute walking distance (6MWD). Inflammation was measured by high sensitivity C-reactive protein (HsCRP) and fibrinogen. Patients were classified by BMI as follows: low (<19.9 Kgm²), healthy (20–24.9Kgm²), overweight (25–29.9Kgm²) obese (>30Kg/m²).

Results: There was no difference in gender, age, lung function or smoking history between patients grouped according to BMI. However, there was a difference in PWV, systolic BP, 6MWD and inflammation between the groups (p<0.05). The difference in PWV remained after adjustment for age and mean BP (Table 1). Overweight and obese patients (BMI <25) had greater PWV and inflammation, while obese patients had the poorest 6MWD.

Conclusions: The findings suggest obese patients with COPD have greater CV risk which may be a result of poorer physical capacity and greater inflammation. Optimisation of BMI in COPD may improve outcomes further follow-up of this cohort will evaluate the prognostic value of arterial stiffness and possible therapeutic targets.
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.Landbo et al., Prognostic value of nutritional status in chronic obstructive pulmonary disease, Am JRespirCrit Care Med, Vol. 160, 1999, pp. 1856-61.

2.Mannino et al., Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD, Eur Respir J, Vol. 32, No. 4, 2008, pp. 962-969.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 64 - 65
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.056 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Nichola Gale
AU  - Ali Albarrati
AU  - Margaret Munnery
AU  - Dennis Shale
AU  - John Cockcroft
PY  - 2016
DA  - 2016/11/24
TI  - 7.10 AORTIC STIFFNESS AND BODY MASS INDEX (BMI) IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD)
JO  - Artery Research
SP  - 64
EP  - 65
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.056
DO  - 10.1016/j.artres.2016.10.056
ID  - Gale2016
ER  -

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