Artery Research

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Volume 16, Issue C, December 2016, Pages 51 - 52

3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION

Authors
Junjing Su1, Charlotte Manisty2, Kim H. Parker3, Soren Mellemkjaer4, Luke Howard5, Ulf Simonsen1, Alun Hughes2
1Department of Biomedicine, Aarhus University, Denmark
2Institute of Cardiovascular Science, University College London, UK
3Department of Bioengineering, Imperial College London, UK
4Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
5National Heart and Lung Institute, Imperial College London, UK
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.014How to use a DOI?
Abstract

Background: The objective of the study was to apply wave intensity analysis (WIA) in the pulmonary artery to characterise the magnitude, origin, type and timing of arterial waves in individuals with and without pulmonary hypertension (PH).

Methods: Right heart catheterisation was performed using a pressure and Doppler flow sensor tipped catheter to obtain simultaneous pressure and flow velocity measurements in the pulmonary artery. WIA was applied to the acquired data (1).

Results: In controls (n = 10), the wave speed in the pulmonary artery was 3.03 m/s (2.69 – 3.91 m/s) and this increased in pulmonary arterial hypertension (PAH, n = 11, 11.9 m/s [10.5 – 16.4 m/s]) and chronic thromboembolic pulmonary hypertension patients (CTEPH, n = 10, 15.1 m/s [11.5 – 16.8 m/s]). Wave intensity was significantly greater in PH patients compared to controls. Wave reflection index (WRI) was 3.81 % (3.58 – 6.24 %) in controls, 23.4 % (17.5 – 29.7 %) in PAH and 30.4 % (11.9 – 35.6 %) in CTEPH patients. WRI was not related to pulmonary vascular resistance or right ventricular fractional area change and patients with mildly and severely elevated pulmonary pressure had similar WRI.

Conclusions: Wave speed, wave intensity and wave reflection in the pulmonary artery was higher in PH patients indicating increased arterial stiffness, right ventricular work and vascular impedance mismatch, respectively. While WRI does not reflect the severity of PH in established disease, the presence of increased wave reflection could be a novel early marker of pulmonary vascular disease.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
51 - 52
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.014How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Junjing Su
AU  - Charlotte Manisty
AU  - Kim H. Parker
AU  - Soren Mellemkjaer
AU  - Luke Howard
AU  - Ulf Simonsen
AU  - Alun Hughes
PY  - 2016
DA  - 2016/11/24
TI  - 3.4 WAVE INTENSITY ANALYSIS PROVIDES NOVEL INSIGHTS INTO PULMONARY HYPERTENSION
JO  - Artery Research
SP  - 51
EP  - 52
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.014
DO  - 10.1016/j.artres.2016.10.014
ID  - Su2016
ER  -