8.1 ARTERIAL STIFFNESS, BLOOD PRESSURE AND CARDIAC OUTPUT STUDY

DOI

10.1016/j.artres.2016.10.057How to use a DOI?

Abstract

We are planning a prospective study in 200 patients with an abdominal artery aneurysm (AAA). Non-invasive measurements will be performed including tonometry-based pulse wave analysis (PWA) and pulse wave velocity (PWV), echocardiography, and 24-hour blood pressure measurements.

This study will provide insight in how PWV/PWA-parameters can help identify characteristics of prostheses used to treat AAA that best match native aortic characteristics and will lead to the best long-term outcome after aneurysm repair. Also the interaction between blood pressure (and control) and cardiac output will be evaluated. These results will form the basis for evidence-based practice for stent choice and lead to better outcomes after AAA treatment. First we will validate non-invasive against invasive central pressure in 20 patients treated with endovascular aneurysm repair (EVAR).

This study will provide insight if arterial stiffness parameters change over time after treatment of AAA and the possible role of PWV/PWA for the surveillance after treatment. We expect to provide insight in the various determinants of the PWV/PWA-parameters pre- and post-repair of AAA evaluation also includes graft material, intraluminal thrombus, and inflammation. We will study whether the different PWV/PWA parameters predict outcome after AAA repair for different prostheses.

Finally, this study will reveal whether parameters of cardiac output obtained by tonometry correspond with parameters obtained by echocardiography in AAA patients. If so, the PWV/PWA measurement can detect cardiologic problems at an early stage during follow-up. By early treatment, the development of heart failure can be delayed or even prevented. We look forward to input on our study-plan.

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TY  - JOUR
AU  - Suzanne Holewijn
AU  - Erik Groot Jebbink
AU  - Wim Aengevaeren
AU  - Jasper Martens
AU  - Marcel Hovens
AU  - Michel Reijnen
PY  - 2016
DA  - 2016/11/24
TI  - 8.1 ARTERIAL STIFFNESS, BLOOD PRESSURE AND CARDIAC OUTPUT STUDY
JO  - Artery Research
SP  - 65
EP  - 65
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.057
DO  - 10.1016/j.artres.2016.10.057
ID  - Holewijn2016
ER  -