Artery Research

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Volume 16, Issue C, December 2016, Pages 76 - 76

11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE

Authors
Rasmus K. Carlsen1, Christian D. Peters1, Esben Laugesen2, Simon Winther3, Dinah S. Khatir1, Hans E. Boetker3, Morten Boettcher4, Per Ivarsen1, My Svensson5, Niels H. Buus6
1Department of Renal Medicine, Aarhus University Hospital, Aarhus, Denmark
2Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark
3Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark
4The Danish Diabetes Academy, Odense University Hospital, Odense, Denmark
5Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
6Department of Internal Medicine, Hospital Unit West, Herning, Denmark
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.095How to use a DOI?
Abstract

Background: We recently reported that central blood pressure (BP) obtained non-invasively in chronic kidney disease (CKD) patients significantly underestimated the central BP with decreasing eGFR in comparison with invasively measured true central BP in the aorta. This post-hoc analysis investigated whether the presence of aortic calcification affected non-invasive estimates of central BP.

Methods: CKD stage 4–5 patients undergoing coronary angiography were included. Invasive aortic BP was measured through angiography catheters. Non-invasive central BP was obtained with the SphygmoCor device. Calcium score (CS) in the aorta was quantified using CT.

Results: Twenty-four patients were enrolled (meanSD): 63% males, age 53±11 years, and eGFR 95 ml/min/1.73 m2. Invasive aortic SBP was 152±23 mmHg. Estimated central SBP was 133±20 mmHg. Ten patients had a CS=0 in both ascending and descending aorta, 2 patients had ascending aortic CS>0 while 8 patients had descending aortic CS>0 and 4 patients had both ascending and descending aortic CS>0. In patients with CS>0 in the descending aorta, central SBP was underestimated by 4(117) mmHg (P=0.02) compared to patients with CS=0. No significant difference was found between patients with and without calcium in the ascending aorta (P=0.13). In patients with CS>0 in both descending and ascending aorta central SBP was underestimated by 14(326) mmHg (P=0.02) compared to patients with CS=0 in both segments.

Conclusion: In advanced CKD, aortic calcification significantly affected the difference between estimated and invasively measured central BP. This may question the usefulness of non-invasive estimates of central BP in high-risk patients with severe aortic calcification.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
76 - 76
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.095How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Rasmus K. Carlsen
AU  - Christian D. Peters
AU  - Esben Laugesen
AU  - Simon Winther
AU  - Dinah S. Khatir
AU  - Hans E. Boetker
AU  - Morten Boettcher
AU  - Per Ivarsen
AU  - My Svensson
AU  - Niels H. Buus
PY  - 2016
DA  - 2016/11/24
TI  - 11.7 AORTIC CALCIUM SCORE AFFECTS NON-INVASIVELY OBTAINED ESTIMATES OF CENTRAL BLOOD PRESSURE IN PATIENTS WITH ADVANCED CHRONIC KIDNEY DISEASE
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.095
DO  - 10.1016/j.artres.2016.10.095
ID  - Carlsen2016
ER  -