12.2 HIGH PULSE WAVE VELOCITY IS ASSOCIATED WITH INCREASED VISIT-TO-VISIT SYSTOLIC BLOOD PRESSURE VARIABILITY IN CONTROLLED ARTERIAL HYPERTENSION

Elena Troitskaya; Yulia Kotovskaya; Zhanna Kobalava

doi:10.1016/j.artres.2016.10.100

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Volume 16, Issue C, December 2016, Pages 77 - 77

12.2 HIGH PULSE WAVE VELOCITY IS ASSOCIATED WITH INCREASED VISIT-TO-VISIT SYSTOLIC BLOOD PRESSURE VARIABILITY IN CONTROLLED ARTERIAL HYPERTENSION

Authors

Elena Troitskaya, Yulia Kotovskaya, Zhanna Kobalava

Peoples’ Friendship University of Russia, Moscow, Russia

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.100 How to use a DOI?
Abstract: Background: Visit-to-visit blood pressure variability (BPV) is associated with adverse cardiovascular outcomes in different patients’ populations^1–2. Arterial stiffness is a potential mechanism of increased visit-to-visit BPV³. Carotid–femoral PWV has become increasingly important for total cardiovascular risk estimation.

Materials and methods: 52 pts (20 men, age 58.9±9.0 yrs 4 smokers 6 diabetics) were treated to target BP<140/90mmHg with a RAAS-inhibitor/amlodipine combination for 14 months. Baseline brachial BP was 163.4±8.1/100.9±4.2mmHg achieved-123.7±9.7/76.8±6.7mmHg. Central BP and PWV were measured at baseline and after 14 months. Individual values of PWV were assessed according to age and BP categories⁴. BPV was calculated as SD for 5 visits during 8 months after target BP achievement.p<0.05 was considered significant.

Results: Baseline central BP was 137.8±17.3/86.6±12.0mmHg, achieved 125.2±13.5/80.3±6.6mmHg (p<0.05). Baseline PWV varied from 7.6 to 19.2 m/s (median 12.2 m/s), achieved – from 9.9 to 17.4 m/s (median 13.4 m/s),p>0.05. Normal values of PWV according to individual reference values were observed in 25.5% of patients (group1, mean PWV 10.0±1.5 m/s), increased – in 74.5% (group2, mean PWV 13.8±2.4 m/s). Groups were similar by age, gender, metabolic risk factors, baseline and achieved BP and visit-to-visit BPV. SBPV range was 1.79–16.79 mmHg (tertile I<5.38 II 5.38 – 7.78 III>7.78 mmHg). Increased PWV value was more often observed in the III tercile of visit-to-visit SBPV (90.3% comparing to 58.8% in tercile I and 73.3% in tercile II, Pearson (χ²)=5.9,p<0.05).

Conclusion: Elevation of PWV above individual reference values in patients with uncomplicated AH is associated with higher visit-to-visit SBPV. This finding confirms role of arterial stiffness in visit-to-visit BPV increase.
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.PM Rothwell, SC Howard, E Dolan, E O’Brien, JE Dobson, B Dahlof, PS Sever, and NR Poulter, Prognostic significance of visit-to-visit variability, maximum systolic blood pressure, and episodic hypertension, Lancet, Vol. 375, No. 9718, 13 Mar 2010, pp. 895-905. Copyright 2010 Elsevier Ltd

2.C Tai, Y Sun, N Dai, D Xu, W Chen, J Wang, A Protogerou, TT van Sloten, J Blacher, ME Safar, Y Zhang, and Y Xu, Prognostic significance of visit-to-visit systolic blood pressure variability: a meta-analysis of 77,299 patients, J Clin Hypertens (Greenwich), Vol. 17, No. 2, Feb 2015, pp. 107-15. © 2015 Wiley Periodicals, Inc

3.H Song, F Wei, Z Liu, Y Zhao, L Ye, F Lu, H Zhang, Y Diao, Z Qi, and J Xu, Visit-to-visit variability in systolic blood pressure: correlated with the changes of arterial stiffness and myocardial perfusion in on-treated hypertensive patients, Clin Exp Hypertens, Vol. 37, No. 1, 2015, pp. 63-9.

4.Reference Values for Arterial Stiffness’ Collaboration, Determinants of pulse wave velocity in healthy people and in the presence of cardiovascular risk factors: ‘establishing normal and reference values’, Eur Heart J, Vol. 31, No. 19, Oct 2010, pp. 2338-50.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 77 - 77
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.100 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Elena Troitskaya
AU  - Yulia Kotovskaya
AU  - Zhanna Kobalava
PY  - 2016
DA  - 2016/11/24
TI  - 12.2 HIGH PULSE WAVE VELOCITY IS ASSOCIATED WITH INCREASED VISIT-TO-VISIT SYSTOLIC BLOOD PRESSURE VARIABILITY IN CONTROLLED ARTERIAL HYPERTENSION
JO  - Artery Research
SP  - 77
EP  - 77
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.100
DO  - 10.1016/j.artres.2016.10.100
ID  - Troitskaya2016
ER  -

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