15.5 ASSOCIATION OF A NEW SURROGATE OF TOTAL ARTERIAL COMPLIANCE WITH LEFT VENTRICULAR MASS: THE SAFAR STUDY

Theodore Papaioannou; Athanase Protogerou; Antonis Argyris; Evangelia Aissopou; Eftymia Nasothymiou; Christos Tountas; Petros Sfikakis; Nikolaos Stergiopulos; Dimitrios Tousoulis

doi:10.1016/j.artres.2016.10.136

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Volume 16, Issue C, December 2016, Pages 86 - 87

15.5 ASSOCIATION OF A NEW SURROGATE OF TOTAL ARTERIAL COMPLIANCE WITH LEFT VENTRICULAR MASS: THE SAFAR STUDY

Authors

Theodore Papaioannou⁴, Athanase Protogerou², Antonis Argyris³, Evangelia Aissopou³, Eftymia Nasothymiou³, Christos Tountas³, Petros Sfikakis³, Nikolaos Stergiopulos⁴, Dimitrios Tousoulis¹

¹Biomedical Engineering Unit, 1st Department of Cardiology, “Hippokration” Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece

²Cardiovascular Prevention & Research Unit, Department of Pathophysiology; Medical School, National and Kapodistrian University of Athens, Greece

³Hypertension Center and Cardiovascular Research Laboratory, 1st Department of Propaedeutic Medicine, “Laiko” Hospital, Medical School, National and Kapodistrian University of Athens, Greece

⁴Laboratory of Hemodynamics and Cardiovascular Technology, Institute of Bioengineering, École Polytechnique Fédérale de Lausanne, Switzerland

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.136 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

We investigated the association of total arterial compliance (C_T) with left ventricular mass (LVM) and hypertrophy (LVH). The study hypothesis was that C_T may be better related with LVM compared to the gold-standard regional aortic stiffness.

Methods: Two hundred twenty six subjects with established hypertension (untreated or treated with antihypertensive drugs) or with suspected hypertension underwent blood pressure (BP) assessment, carotid-to-femoral pulse wave velocity (cf-PWV) and echocardiographic measurement of LVM. LVM index (LVMI) was calculated by the ratio of LVM to body surface area. C_T was estimated by a previously proposed and validated formula: C_T = 36.7 / PWV² [ml/mmHg], which is based on Bramwell-Hill equation.

Results: LVMI was significantly associated with age (r=0.207, p=0.002), systolic BP (r=0.248, p<0.001), diastolic BP (r=0.139, p=0.04), mean BP (r=0.212, p=0.002), pulse pressure (r=0.212, p=0.002), heart rate (r=−0.172, p=0.011), cf-PWV (r=0.268, p<0.001) and C_T (r=−0.317, p<0.001). The highest correlation was observed for C_T which was significantly stronger than the respective correlation of cf-PWV (p<0.001). Multivariate analysis showed that C_T was a stronger determinant, compared to cf-PWV, of LVMI and LVH.

Conclusion: Total (systemic) arterial compliance is better associated with left ventricular mass and hypertrophy than the cf-PWV. It remains to be further explored whether C_T has also a superior prognostic value beyond and above local or regional (segmental) estimates of pulse wave velocity.

References

1.O Vardoulis, TG Papaioannou, and N Stergiopulos, On the estimation of total arterial compliance from aortic pulse wave velocity, Ann Biomed Eng, Vol. 40, No. 12, 2012, pp. 2619-2626.

2.TG Papaioannou, AD Protogerou, N Stergiopulos, O Vardoulis, C Stefanadis, M Safar, and J Blacher, Total arterial compliance estimated by a novel method and all-cause mortality in the elderly: the PROTEGER study, AGE(Dotr), 2014, pp. 9661.

3.GC Verwoert, SE Elias-Smale, D Rizopoulos, MT Koller, EW Steyerberg, A Hofman, et al., Does aortic stiffness improve the prediction of coronary heart disease in elderly?, The Rotterdam Study. J Hum Hypertens, Vol. 26, 2012, pp. 28-34.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 86 - 87
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.136 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Theodore Papaioannou
AU  - Athanase Protogerou
AU  - Antonis Argyris
AU  - Evangelia Aissopou
AU  - Eftymia Nasothymiou
AU  - Christos Tountas
AU  - Petros Sfikakis
AU  - Nikolaos Stergiopulos
AU  - Dimitrios Tousoulis
PY  - 2016
DA  - 2016/11/24
TI  - 15.5 ASSOCIATION OF A NEW SURROGATE OF TOTAL ARTERIAL COMPLIANCE WITH LEFT VENTRICULAR MASS: THE SAFAR STUDY
JO  - Artery Research
SP  - 86
EP  - 87
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.136
DO  - 10.1016/j.artres.2016.10.136
ID  - Papaioannou2016
ER  -

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