8.3 QUANTIFYING HEART AND ARTERIAL CONTRIBUTIONS TO CENTRAL BLOOD PRESSURE IN SYSTOLE

DOI

10.1016/j.artres.2016.10.059How to use a DOI?

Abstract

Background: A recent study has shown that the central pressure waveform could be determined by a very small set of parameters accounting for the physical properties of the heart and the arteries [1]. Particularly, main pressure features like first systolic shoulder (P1) and systolic (P2) pressures were estimated accurately.

Methods: By combining a numerical virtual population (n=3,325) similar to [2] and experimental data acquired from a pressure/Doppler flow velocity transducer place in the ascending aorta in 18 patients (meanSD: age 63±11 yr, aortic BP 136±23/73±13 mmHg) at the time of cardiac catheterization, we assessed the accuracy of those predictions for magP1 (P1-DBP) and P2 using respectively a water hammer [3] and a 3-element Windkessel models [4]. Contributions of the heart and arterial properties to these estimates though respectively blood velocity, volume and pulse wave velocity, compliance, resistance were then derived from the theoretical models used.

Results: P1 and P2 estimates agreed well with theoretical pressure both in the numerical dataset (mean+//0-SD difference, 1.1±3.2 mmHg and -1.6±3.1 mmHg respectively) and the clinical cohort (mean+//0-SD difference, -2.4±5.5 mmHg and 1.9±6.5 mmHg respectively). The ratio arterial-to-heart contribution has been shown to be fairly constant as magP1 was increasing.

Conclusions: Arteries and heart contribute as much to rise in P1. More clinical data are being collected to quantify the contributions of the heart and arteries to P2.

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TY  - JOUR
AU  - Samuel Vennin
AU  - Ye Li
AU  - Marie Willemet
AU  - Henry Fok
AU  - Brian Clapp
AU  - Jordi Alastruey
AU  - Phil Chowienczyk
PY  - 2016
DA  - 2016/11/24
TI  - 8.3 QUANTIFYING HEART AND ARTERIAL CONTRIBUTIONS TO CENTRAL BLOOD PRESSURE IN SYSTOLE
JO  - Artery Research
SP  - 65
EP  - 65
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.059
DO  - 10.1016/j.artres.2016.10.059
ID  - Vennin2016
ER  -