6.5 ASSOCIATION BETWEEN INCREASED ARTERIAL STIFFNESS AND HBA1C AND LDL CHOLESTEROL LEVEL IN TYPE 2 DIABETES PATIENTS

Ilona Hegyi; Terez Szabo; Eszter Szele; Istvan Vasas

doi:10.1016/j.artres.2016.10.041

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Volume 16, Issue C, December 2016, Pages 60 - 60

6.5 ASSOCIATION BETWEEN INCREASED ARTERIAL STIFFNESS AND HBA1C AND LDL CHOLESTEROL LEVEL IN TYPE 2 DIABETES PATIENTS

Authors

Ilona Hegyi, Terez Szabo, Eszter Szele, Istvan Vasas

Kardirex Healthcare Centre, Gyor, Hungary

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.041 How to use a DOI?
Abstract: Background: In patient with type 2 diabetes mellitus (T2DM) the atherosclerosis apper in younger age, in both gender and the cardiovascular risk is much higher. The aim of our study was to examine the association between pulse wave velocity (PWV) and glycated haemoglobin (HbA1c) and low density lipoprotein (LDL-C) level in patient with T2DM. (1,2)

Methods: We performed a prospective observational study, outpatient measurement included: aorta PWV measured by arteriograph, HbA1c and LDL-C level. The cut off-points are: PWV: 9 m/s, LDL-C: 2,5 mmol/l, HbA1c: 6%. In the first part of the analysis were included 169 patients with T2DM (106 men, 63 women, average age: 59 year), and were 152 patients (99 men, 53 women, average age: 59 year) in the second part. Linear regression analysis was carried using SPSS software.Values of p<0.05 were considered to be statistically significant.

Results: In the first investigation we found signicantly higher PWV in 87 patients (51%), mean: 9,27 m/s. The LDL-C level was higher than 2,5 mmol/l in 67% of cases, mean: 2,935 mmol/l. The second investigation underline a strict linear association between PWV and HbA1c (means: PWV: 9,286 m/s, HbA1c: 6,792 %.)

Conclusion: Our studies show parallel association between elevated HbA1c and PWV, as well as between higher LDL-C and PWV, which represent the elevated arterial stiffness (AS). Measurement of arterial stiffness can provide additional information about cardiovascular risk in patient with T2DM, which support the importance of arteriograph the only type of non-invasive method for AS measurement. (3,4)
Open Access: This is an open access article distributed under the CC BY-NC license.

References

1.AL Catapano, Z Reiner, G De Backer, I Graham, MR Taskinen, O Wiklund, S Agewall, E Alegria, MJ Chapman, P Durrington, S Erdine, J Halcox, R Hobbs, J Kjekshus, P Perrone Filardi, G Riccardi, RF Storey, and D Wood, Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS), Atherosclerosis, Vol. 217, No. 1, Jul 2011, pp. 1-44.

2.Y Wang, CJ Lammi-Keefe, L Hou, and G Hu, Impact of low-density lipoprotein cholesterol on cardiovascular outcomes in people with type 2 diabetes: a meta-analysis of prospective cohort studies, Diabetes Res Clin Pract, Vol. 102, No. 1, Oct 2013, pp. 65-75.

3.HH Chiang, FY Tseng, CY Wang, CL Chen, YC Chen, TT See, and HF Chen, All-cause mortality in patients with type 2 diabetes in association with achieved hemoglobin A(1c), systolic blood pressure, and low-density lipoprotein cholesterol levels, PLoS One, Vol. 9, No. 10, 27 Oct 2014, pp. e109501.

4.M Nakamura, T Yamashita, J Yajima, Y Oikawa, K Sagara, A Koike, H Kirigaya, K Nagashima, H Sawada, and T Aizawa, Shinken Database Study Group, Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease, Hypertens Res, Vol. 33, No. 10, Oct 2010, pp. 1018-1024.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 60 - 60
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.041 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - Ilona Hegyi
AU  - Terez Szabo
AU  - Eszter Szele
AU  - Istvan Vasas
PY  - 2016
DA  - 2016/11/24
TI  - 6.5 ASSOCIATION BETWEEN INCREASED ARTERIAL STIFFNESS AND HBA1C AND LDL CHOLESTEROL LEVEL IN TYPE 2 DIABETES PATIENTS
JO  - Artery Research
SP  - 60
EP  - 60
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.041
DO  - 10.1016/j.artres.2016.10.041
ID  - Hegyi2016
ER  -

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