12.10 REDUCED VENTRICULAR-ARTERIAL COUPLING AS AN EARLY MARKER OF CARDIOVASCULAR REMODELING IN HYPERTENSIVE MEN

DOI

10.1016/j.artres.2016.10.108How to use a DOI?

Abstract

Objective: To evaluate ventricular-arterial coupling (VAC), left ventricular hypertrophy (LVH), diastolic function and arterial stiffness in young and middle-aged men with uncomplicated arterial hypertension

Methods: 97 young men aged 18–27 years (21,2±1,9 years, BP 156,5±14,0/98,5±9,1 mmHg) and 68 middle-aged men aged 40–60 years (n=68, age 53,9±7,2 years, BP 152,7±9,6/94,8±7,8 mmHg) (M) underwent simultaneous EchoCG, blood pressure (BP) and pulse wave velocity measurement. VAC index was calculated arterial elastance (Ea) and left ventricular elastance (Ees) ratio. Ea=end-systolic pressure/stroke volume, Ees=end-systolic pressure/end-systolic volume. LVH was diagnosed if LV mass index was >115 g/m2, Increased arterial stiffness -if PWV >10 m/s, diastolic dysfunction – if E/A <1,0 and E/E’<7 m/s.

Results: In young men Eea 1,86±0,32 and index VAC (0,52±0,10) was similar to that in middle-aged (1,9±0,47 and 0,48±0,19, respectively), despite that Ees in young men was significantly lower (3,67±0,85) than in middle-aged men (4,6±2,1, p<0,01). VAC index <0,5 was found in 34% young men and in 57% middle-aged men (p<0,05), LVH in 7,4% and 67% (p<0,05), diastolic dysfunction 4,1% and 62%, respectively. VAC index was similar in those with and without LVH or diastolic dysfunction in the both age groups. In young men with LVH VAC index was 0,63±0,26, without LVH 0,54±0,12, in middle-aged patients with LVH – 0,45±0,16, without LVH – 0,49±0,21. In young men with diastolic dysfunction VAC index was 0,61±0,13, without diastolic dysfunction – 0,58±0,16. In middle-aged men 0,45±0,14 and 0,48±0,16, respectively. PWV>10 m/s was found in 22,7% of young men and in 80,1% of middle-aged (p<0,05). No significant correlation between VAC index and BP, LVMI, PWV, E/A, E/E’ was found.

Conclusion: Decrease in the VAC index<0,5 indicating LV-arterial uncoupling may be an early marker of cardiovascular remodeling in hypertensive men that may be observed before development of LVH, diastolic dysfunction or increased arterial stiffness.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Anna Bogomaz
AU  - Yulia Kotovskaya
AU  - Zhanna Kobalava
PY  - 2016
DA  - 2016/11/24
TI  - 12.10 REDUCED VENTRICULAR-ARTERIAL COUPLING AS AN EARLY MARKER OF CARDIOVASCULAR REMODELING IN HYPERTENSIVE MEN
JO  - Artery Research
SP  - 79
EP  - 79
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.108
DO  - 10.1016/j.artres.2016.10.108
ID  - Bogomaz2016
ER  -