Artery Research

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Volume 16, Issue C, December 2016, Pages 90 - 90

PO-03 IMPROVEMENT IN POST-TRANSPLANT HYPERTENSION IN LIVING DONOR RENAL TRANSPLANTATION

Authors
Ekamol Tantisattamo1, Weera Sukhumthammarat2, Prapaipan Putthapiban3, Wasawat Vutthikraivit4, Siwadon Pitukweerakul5
1Multi-Organ Transplant Center, Division of Nephrology, Department of Internal Medicine, Oakland University William Beaumont School of Medicine, Royal Oak, MI, United States
2Department of Oral Medicine and Periodontics, Faculty of Dentristry, Mahidol University, Bangkok, Thailand
3Department of Pharmacology, Faculty of Sciences, Mahidol University, Bangkok, Thailand
4Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
5Department of Internal Medicine, Presence St. Francis Hospital, Evanston, IL, United States
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.08.011How to use a DOI?
Abstract

Objectives: Since genetic factor determines part of hypertensive phenotype, we aim to demonstrate the role of transplanted kidney from normotensive living donors in post-transplant hypertension (HTN).

Methods: From 1.5-year-medical record review yielded 103 kidney transplant recipients in whom living-donor renal transplantation (LDRT) was performed in 32 (15 living-related renal transplantation (LRRT) and 17 living-unrelated renal transplantation (LURT)).

Results: Of all 32 recipients, mean age was 51.30 years old (21.42–79.53) and 50% were male. Mean duration of follow-up was 8.4 months (0.63–16.33). Up to 93.75% of recipients had pre-transplant hypertension, and 56.25% became non-hypertensive after transplantation, which was defined as SBP≤140, DBP≤90, or being on≤2 BP agents regardless SBP or DBP (Figure 1). Mean post-transplant systolic blood pressure (SBP) was lower than pre-transplant SBP but not statistically significant (132.88+/−2.54 vs. 134.75+/−3.01, p= 0.6366) as same as mean DBP (77.84+/−1.88 vs. 82.25+/−2.39, p= 0.1520). The number of pre- and post-transplant blood pressure medications was 1.94 and 1.28, respectively. in LRRT group, 5 of 13 (38.46%) pre-transplant hypertensive patients became normotensive while 11 of 17 (64.71%) patients in LURT group were non-hypertensive(Figure 2). Mean post-transplant SBP was higher than mean pre-transplant SBP in LRRT group (1.33.73+/−3.33 vs. 129.67+/−4.40, p=0.4680); however, mean post-transplant DBP in LRRT group (77.93+/−2.68 vs. 79.40+/−3.20, p=0.7273) as well as mean SBP (132.12+/−3.85 vs. 139.24+/−3.93, p=0.2049) and mean DBP (77.76+/−2.71 vs. 84.76+/−3.48, p=0.1223) in LURT were lower than those during pre-transplant periods. The mean number of antihypertensive medications was decreased in post-transplant compared to pre-transplant in both LRRT (1+/−0.24 vs. 1.73+/−0.33, p=0.0844) and LURT (1.53+/−0.12 vs. 2.12+/−0.28, p=0.0616) groups.

Conclusion: Hypertension was resolved in more than half of the pre-transplant hypertensive patients after kidney transplantation. Since higher number of LURT recipients becomes normotensive, the possibility of hypertensive genotype in living-related donor kidneys may contribute to post-transplant HTN in some LRRT recipients.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
90 - 90
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.08.011How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Ekamol Tantisattamo
AU  - Weera Sukhumthammarat
AU  - Prapaipan Putthapiban
AU  - Wasawat Vutthikraivit
AU  - Siwadon Pitukweerakul
PY  - 2016
DA  - 2016/11/24
TI  - PO-03 IMPROVEMENT IN POST-TRANSPLANT HYPERTENSION IN LIVING DONOR RENAL TRANSPLANTATION
JO  - Artery Research
SP  - 90
EP  - 90
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.08.011
DO  - 10.1016/j.artres.2016.08.011
ID  - Tantisattamo2016
ER  -