11.3 ATHEROMATOSIS AND ENDOTHELIAL RESPONSE OF THE SMALL PERIPHERAL ARTERIES: A PERITONEAL DIALYSIS VERSUS HEMODIALYSIS PATIENTS MISMATCH

Athanasios Angelis; Nikolaos Ioakimidis; Penny Giannou; Ioannis Felekos; Vasiliki Kakiouzi; Konstantina Aggeli; Dimitrios Petras; Charalampos Vlachopoulos; Dimitrios Tousoulis

doi:10.1016/j.artres.2016.10.091

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Volume 16, Issue C, December 2016, Pages 74 - 74

11.3 ATHEROMATOSIS AND ENDOTHELIAL RESPONSE OF THE SMALL PERIPHERAL ARTERIES: A PERITONEAL DIALYSIS VERSUS HEMODIALYSIS PATIENTS MISMATCH

Authors

Athanasios Angelis¹, Nikolaos Ioakimidis¹, Penny Giannou², Ioannis Felekos¹, Vasiliki Kakiouzi¹, Konstantina Aggeli¹, Dimitrios Petras², Charalampos Vlachopoulos¹, Dimitrios Tousoulis¹

¹Hippokration University Hospital, 1st Department of Cardiology, Athens, Greece

²Hippokration General Hospital, Department of Nephrology, Athens, Greece

Available Online 24 November 2016.

DOI: 10.1016/j.artres.2016.10.091 How to use a DOI?
Abstract: Background: Peritoneal dialysis (PD) and hemodialysis (HD) are treatment options for end stage renal disease (ESRD). However, few are known on the cardiovascular impose of those therapeutic modalities. Our aim is to uncover endothelial damage and subclinical atheromatous process in male patients on chronic ESRD treated by either of those methods.

Methods: 84 male ESRD patients, 46 on HD and the rest 38 on PD without apparent cardiovascular disease enrolled the study. The two groups did not differ statistically in age, (64,9 vs 64) prevalence of hypertension, diabetes mellitus, smoking and lipid profile. All underwent common carotid ultrasound intima –media thickness (cIMT) evaluation to uncover subclinical atheromatosis. Endothelial function was estimated by the SHIM-5 score (theoretical range 0–25) that grades erectile potency, a nitric oxide depended phenomenon based on vasodilator ability of the penile vasculature. Higher grading indicates a healthier endothelial vascular status.

Results: HD patients had statistically higher cIMT (1.5 vs 0.85) and lower SHIM-5 score grading (8.8 vs 12.8) compering to PD patients. Statistics remained significant after adjustment for age, body mass index, presence of hypertension, diabetes mellitus, tobacco use and statin therapy.

Conclusion: Peritoneal dialysis ESRD male patients appear to have a favorable endothelial function and a mild atheromatous load as compared to hemodialysis patients. Our data may offer clinical information guiding further therapeutic efforts in patients with end stage renal disease, a special population where cardiovascular morbidity remains typically high.
Open Access: This is an open access article distributed under the CC BY-NC license.

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Journal: Artery Research
Volume-Issue: 16 - C
Pages: 74 - 74
Publication Date: 2016/11/24
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2016.10.091 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - Athanasios Angelis
AU  - Nikolaos Ioakimidis
AU  - Penny Giannou
AU  - Ioannis Felekos
AU  - Vasiliki Kakiouzi
AU  - Konstantina Aggeli
AU  - Dimitrios Petras
AU  - Charalampos Vlachopoulos
AU  - Dimitrios Tousoulis
PY  - 2016
DA  - 2016/11/24
TI  - 11.3 ATHEROMATOSIS AND ENDOTHELIAL RESPONSE OF THE SMALL PERIPHERAL ARTERIES: A PERITONEAL DIALYSIS VERSUS HEMODIALYSIS PATIENTS MISMATCH
JO  - Artery Research
SP  - 74
EP  - 74
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.091
DO  - 10.1016/j.artres.2016.10.091
ID  - Angelis2016
ER  -

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