7.2 POOR SLEEP QUALITY RELATED TO WORSE VASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS

DOI

10.1016/j.artres.2016.10.048How to use a DOI?

Abstract

Background: Poor sleep quality has been related to poor vascular function and higher risk of cardiovascular disease in the general population. Persons with multiple sclerosis (MS) exhibit a high cardiovascular risk, and report poor sleep quality. To date, the association between sleep quality and vascular health in MS has not been investigated. Objective: To investigate differences in vascular health between good and poor quality sleepers with MS. Methods: After a 10 minute rest in the supine position, resting heart rate (HR) and brachial blood pressure (BP) were collected.Aortic SBP, augmentation index (AIX), HR normalized AIX (AIX@HR75), subendocardial viability ratio (SEVR), end systolic pressure (ESP), and central pulse wave velocity (PWVc) were measured with applanation tonometry in individuals with MS (n=49). Carotid intima-media thickness (IMT) and beta-stiffness were measured with carotid ultrasound, and peak forearm blood flow (FBF Peak) was measured with strain gauge plethysmography. Sleep quality was measured with the Pittsburgh Sleep Quality Index (>5 was categorized as poor sleep quality). Age was used as a covariate.

Results: AIX@HR75 and SEVR were different between groups, even with age as a covariate, suggesting higher vascular risk for the poor quality sleepers with MS.

Conclusions: This study shows that within the MS population, poor quality sleepers have a higher cardiovascular risk than good quality sleepers. Whether poor sleep raises their cardiovascular risk more than in the general population is an area of future investigation.

	Good quality sleepers with MS (n=23)	Poor quality sleepers with MS (n=26)	Effect of sleep quality		Effect of age
	Mean (SD)	Mean (SD)	p	Partial Eta2	p	Partial Eta2
N Female (%)	18 (75%)	22 (82%)
PSQI score	2.9 (1.5)	9.7 (3.1)
Age	44 ±13	52 ±10
BMI	26.9 ±5.4	28.1± 5.6	.582	0.007	.584	0.007
HR	64 ±10	65± 8	.136	0.048	.014*	0.125
SBP	116 ±14	122 ±14	.384	0.017	.025*	0.105
DBP	72 ±9	74 ±10	.457	0.012	.559	0.007
MAP	86± 10	90 ±11	.403	0.015	.175	0.040
Aortic SBP	106 ±14	114 ±14	.223	0.032	.001**	0.200
AIX	21.1 ±13.7	30.0± 9.0	.082	0.064	<.001**	0.282
AIX@HR75	15.1± 12.0	25.5± 7.6	.007**	0.150	.001**	0.211
SEVR	158± 21	147 ±18	.026*	0.103	.160	0.042
ESP	96 ±12	103± 14	.213	0.034	.007**	0.148
PWVc	6.7± 1.4	7.5± 1.4	.200	0.036	.007**	0.146
PWVc/MAP	0.078± 0.014	0.084 ±0.016	.376	0.017	.063	0.073
IMT	0.51± 0.11	0.53 ±0.12	.571	0.007	<.001**	0.342
Beta	7.3 ±2.3	8.1± 2.7	.785	0.002	.002**	0.193
FBF Peak	17.8 4.4	17.2 6.6	.988	0.000	.185	0.038

*

p<0.05

**

p<0.01

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Thessa Hilgenkamp
AU  - Garett Griffith
AU  - Robert Motl
AU  - Tracy Baynard
AU  - Bo Fernhall
PY  - 2016
DA  - 2016/11/24
TI  - 7.2 POOR SLEEP QUALITY RELATED TO WORSE VASCULAR FUNCTION IN INDIVIDUALS WITH MULTIPLE SCLEROSIS
JO  - Artery Research
SP  - 62
EP  - 62
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.048
DO  - 10.1016/j.artres.2016.10.048
ID  - Hilgenkamp2016
ER  -