11.1 ENDOTHELIAL FUNCTION IS IMPAIRED IN WOMEN WHO HAD PRE-ECLAMPSIA

DOI

10.1016/j.artres.2016.10.089How to use a DOI?

Abstract

Background: Women with a history of pre-eclampsia (PE) are at higher risk of cardiovascular disease later in life. We evaluated the cardiovascular health of women who had PE in comparison with women who had normotensive pregnancies.

Methods: We assessed heart rate-adjusted augmentation index (AIx SphygmoCor), carotid-femoral pulse wave velocity (PWV SphygmoCor), carotid intima-media thickness (CIMT ultrasound) and brachial flow-mediated dilatation (FMD ultrasound) in women who were pregnant 1–30 years ago.

Results: A total of 166 women (86 cases, 80 controls) attended for vascular studies. Women with a history of PE had higher systolic blood pressure (SBP) (130±14 vs 122±10 mmHg P<0.001) and diastolic blood pressure (DBP) (82±9 vs 78±7 mmHg P=0.001) compared with controls. They also had a higher BMI (29.4±6.1 vs 26.6±4.5 kg/m² P=0.002). We found impaired endothelial function (FMD 5.9±3.3 vs 7.0±3.3 %, P=0.017) and greater PWV (7.8±1.6 vs 7.1±1.1 m/s, P=0.002) and heart rate-adjusted AIx (25.7±11.0 vs 22.5± 9.6 %, P=0.023) in cases compared with controls. There was no difference in CIMT (P=0.110). After adjustment for age, BMI and SBP the difference in endothelial function remained statistically significant (P=0.014).

Conclusions: Women who had PE have higher blood pressure and BMI compared to women at similar age who had normotensive pregnancies. A history of PE is also associated with impaired endothelial function which could explain the higher cardiovascular risk in this group.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Christian Delles
AU  - Catriona Brown
AU  - Joanne Flynn
AU  - Shona Kerr
AU  - David Carty
PY  - 2016
DA  - 2016/11/24
TI  - 11.1 ENDOTHELIAL FUNCTION IS IMPAIRED IN WOMEN WHO HAD PRE-ECLAMPSIA
JO  - Artery Research
SP  - 74
EP  - 74
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.089
DO  - 10.1016/j.artres.2016.10.089
ID  - Delles2016
ER  -