Artery Research

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Volume 16, Issue C, December 2016, Pages 70 - 71

9.10 STRUCTURAL AND FUNCTIONAL ARTERIAL ABNORMALITIES IN FIBROMUSCULAR DYSPLASIA ARE IN THE CONTINUUM OF HYPERTENSION: AN IMAGING AND BIOMECHANICAL STUDY

Authors
Louise Marais2, Pierre Boutouyrie2, Hakim Khettab2, Chantal Boulanger2, Aurelien Lorthioir5, Mickael Franck3, Ralph Niarra3, Jean-Marie Renard2, Yann Chambon3, Xavier Jeunemaitre4, Mustapha Zidi1, Pierre-François Plouin5, Stéphane Laurent2, Michel Azizi3
1University Paris Est Creteil, Paris, France
2INSERM U970, Paris Cardiovascular Research Center, Paris, France
3AP-HP – European Hospital Georges Pompidou, Clinical Investigation Center, Paris, France
4University Paris Descartes, Paris, France
5AP-HP – European Hospital Georges Pompidou, Cardiovascular Genetic Unit, Paris, France
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.077How to use a DOI?
Abstract

Fibromuscular dysplasia (FMD) is a non-atherosclerotic non-inflammatory arterial disease of unknown origin. We previously showed the presence of triple signal (TS) at ultrasound within common carotid artery (CCA) wall. We aimed at coupling TS presence with microconstituents of the vessel wall.

We included 50 patients with multifocal FMD, 50 essential hypertensive (HT) patients and 50 healthy subjects (HS) matched for age, sex, ethnicity and BP (HT and FMD). TS score from the right and left CCA were assessed from 15-MHz echotracking system coupled with aplanation tonometry. 14 microconstituents of the CCA, representing geometry, perivascular tethering, and wall material coefficients were derived from fitting of the pressure-diameter curve.

In multivariate analysis, age, hypercholesterolemia and IMT were significantly associated with TS, explaining 9.5% of its variance. TS was more frequent in FMD than HS (49% vs 16%, p<0.01), and HT (32%, p=0.08). When considering the whole population (n=150), several microconstituents appeared correlated with age and BP: particularly, residual stress was higher, and collagen fibers were stiffer with increasing age and BP (p<0.01). TS was positively associated with circular collagen mediated-stiffness (p<0.01), independently of age and BP.

We confirmed that FMD is associated with higher frequency of TS, but with overlap with matched HT and HS. The strong association between TS and carotid remodeling, independently of age and BP, suggests that it corresponds to the muscular transition of an elastic artery [1]. The association of TS with circular collagen stiffness suggests that TS has subtle but measurable mechanical consequences.

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<Previous Article In Issue
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Journal
Artery Research
Volume-Issue
16 - C
Pages
70 - 71
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.077How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Louise Marais
AU  - Pierre Boutouyrie
AU  - Hakim Khettab
AU  - Chantal Boulanger
AU  - Aurelien Lorthioir
AU  - Mickael Franck
AU  - Ralph Niarra
AU  - Jean-Marie Renard
AU  - Yann Chambon
AU  - Xavier Jeunemaitre
AU  - Mustapha Zidi
AU  - Pierre-François Plouin
AU  - Stéphane Laurent
AU  - Michel Azizi
PY  - 2016
DA  - 2016/11/24
TI  - 9.10 STRUCTURAL AND FUNCTIONAL ARTERIAL ABNORMALITIES IN FIBROMUSCULAR DYSPLASIA ARE IN THE CONTINUUM OF HYPERTENSION: AN IMAGING AND BIOMECHANICAL STUDY
JO  - Artery Research
SP  - 70
EP  - 71
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.077
DO  - 10.1016/j.artres.2016.10.077
ID  - Marais2016
ER  -