Artery Research

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Volume 16, Issue C, December 2016, Pages 59 - 60

6.3 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOW-DENSITY NON-CALCIFIED CORONARY PLAQUES IN PATIENTS WITH TYPE 2 DIABETES AND HEALTHY CONTROLS

Authors
Kristian L. Funck1, Esben Laugesen2, Kristian Oevrehus5, Jesper M. Jensen3, Bjarne L. Noergaard3, Damini Dey4, Troels K. Hansen1, Per L. Poulsen1
1Department of Internal Medicine and Endocrinology, Aarhus University Hospital, Aarhus, Denmark
2Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
3The Danish Diabetes Academy, Odense, Denmark
4Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark
5Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.039How to use a DOI?
Abstract

Background: Arterial stiffness may provide non-invasive information about cardiovascular risk in patients with type 2 diabetes. We investigated the association between arterial stiffness and subclinical coronary atherosclerosis in patients with type 2 diabetes and healthy controls.

Methods: Patients with type 2 diabetes and controls were recruited from an on-going study on diabetes complications. Arterial stiffness (carotid-femoral pulse wave velocity [PWV]) was obtained by applanation tonometry (SphygmoCor®, Australia) whereas volumes [mm3] of total [TP], calcified [CP], non-calcified [NCP], and low density non-calcified coronary plaques [LD-NCP]) were obtained by coronary CT-angiography and analyzed by semi-automative software (Autoplaq®, USA). A two-part model was used to describe the association between PWV and 1) the presence of plaques in all participants and 2) the extent of plaques in participants with coronary atherosclerosis.

Results: PWV and coronary atherosclerosis data were available for 49 patients and 63 controls (age 63±10 years, 49% males, diabetes duration 7.7±1.5 years). Patients had higher PWV than controls (9.6±2.4m/s vs. 8.4±1.8m/s, p<0.01). PWV was associated with the presence of plaques in crude analysis (odds ratio per 1m/s increase in PWV: TP 1.5, p<0.01, CP 1.4 p<0.01, NCP 1.4 p<0.01 and LD-NCP 1.3 p=0.03) but not in analysis adjusted for age, sex, blood pressure, and diabetes. In the presence of coronary plaques, PWV was associated with the extent of LDNCP (crude: 1.2 mm3/m/s, p<0.01 adjusted: 1.2mm3/m/s, p=0.02).

Conclusion: The presence and the extent of coronary atherosclerosis is associated with PWV in patients with type 2 diabetes and healthy controls.

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This is an open access article distributed under the CC BY-NC license.

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Journal
Artery Research
Volume-Issue
16 - C
Pages
59 - 60
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.039How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Kristian L. Funck
AU  - Esben Laugesen
AU  - Kristian Oevrehus
AU  - Jesper M. Jensen
AU  - Bjarne L. Noergaard
AU  - Damini Dey
AU  - Troels K. Hansen
AU  - Per L. Poulsen
PY  - 2016
DA  - 2016/11/24
TI  - 6.3 ARTERIAL STIFFNESS IS ASSOCIATED WITH LOW-DENSITY NON-CALCIFIED CORONARY PLAQUES IN PATIENTS WITH TYPE 2 DIABETES AND HEALTHY CONTROLS
JO  - Artery Research
SP  - 59
EP  - 60
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.039
DO  - 10.1016/j.artres.2016.10.039
ID  - Funck2016
ER  -