Artery Research

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Volume 16, Issue C, December 2016, Pages 92 - 92

PO-12 RELATIONS BETWEEN AORTIC STIFFNESS AND LEFT VENTRICULAR MECHANICAL FUNCTION

Authors
Vanessa C. Bell1, Elizabeth L. McCabe2, Martin G. Larson2, 3, Jian Rong3, Allison A. Merz4, Ewa Osypiuk3, Birgitta T. Lehman3, Plamen Stantchev3, Jayashri Aragam5, Emelia J. Benjamin3, 6, 7, Naomi M. Hamburg7, 8, Ramachandran S. Vasan3, 6, 7, Gary F. Mitchell1, Susan Cheng3, 4
1Cardiovascular Engineering, Inc., Norwood, MA, United States
2Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States
3Framingham Heart Study, Framingham, MA, United States
4Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, United States
5Veterans Administration Hospital, West Roxbury, MA, United States
6Department of Epidemiology, Boston University School of Public Health, Boston, MA, United States
7Whitaker Cardiovascular Institute, Preventive Medicine and Cardiology Sections, Boston University School of Medicine, Boston, MA, United States
8Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.08.020How to use a DOI?
Abstract

Objectives: Left ventricular contraction produces longitudinal strain in the proximal aorta. As a result, aortic stiffening may impair optimal mechanical ventricular-vascular coupling and left ventricular (LV) systolic function, particularly in the long axis. LV global longitudinal strain (GLS) has recently emerged as a sensitive measure of early cardiac dysfunction. In this study, we investigated the relation between aortic stiffness and GLS in a large community-based sample.

Methods: In 2516 participants (age 39–90 years, 57% women) of the Framingham Offspring and Omni cohorts, free of cardiovascular disease, we performed tonometry to measure aortic stiffness and echocardiography to assess cardiac function. Aortic stiffness was evaluated as carotid-femoral pulse wave velocity (CFPWV) and as characteristic impedance (Zc), and GLS was calculated using speckle tracking-based measurements.

Results: In multivariable analyses adjusting for age, sex, height, systolic blood pressure, augmentation index, LV structure, and additional cardiovascular disease risk factors, increased CFPWV (β±SE: 0.122±0.030 SD strain per SD CFPWV, P<0.0001) and Zc (0.091±0.029 SD/SD, P=0.002) were both associated with worse (less negative) GLS. We observed effect modification by sex of the relation between Zc and GLS (P=0.004); in sex-stratified multivariable analyses, the relation between greater Zc and worse GLS persisted in women (0.145±0.040, P=0.0003) but not in men (P=0.73).

Conclusion: Higher aortic stiffness was associated with worse GLS after adjusting for hemodynamic variables. Parallel reductions in LV long axis shortening and proximal aortic longitudinal strain in individuals with a stiffened proximal aorta may represent a manifestation of abnormal direct mechanical ventricular-vascular coupling.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
92 - 92
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.08.020How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Vanessa C. Bell
AU  - Elizabeth L. McCabe
AU  - Martin G. Larson
AU  - Jian Rong
AU  - Allison A. Merz
AU  - Ewa Osypiuk
AU  - Birgitta T. Lehman
AU  - Plamen Stantchev
AU  - Jayashri Aragam
AU  - Emelia J. Benjamin
AU  - Naomi M. Hamburg
AU  - Ramachandran S. Vasan
AU  - Gary F. Mitchell
AU  - Susan Cheng
PY  - 2016
DA  - 2016/11/24
TI  - PO-12 RELATIONS BETWEEN AORTIC STIFFNESS AND LEFT VENTRICULAR MECHANICAL FUNCTION
JO  - Artery Research
SP  - 92
EP  - 92
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.08.020
DO  - 10.1016/j.artres.2016.08.020
ID  - Bell2016
ER  -