Artery Research

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Volume 16, Issue C, December 2016, Pages 99 - 100

PO-37 THE IMPACT OF INTRADIALYTIC PEDALING EXERCISE ON ARTERIAL STIFFNESS IN A HEMODIALYSIS POPULATION

Authors
Alexandra B. Cooke1, Vincent Ta1, Yessica-Haydee Gomez2, Sameena Iqbal3, Stella S. Daskalopoulou1
1Division of Experimental Medicine, Department of Medicine, McGill University, Montreal, QC, Canada
2Division of Internal Medicine, Department of Medicine, McGill University Health Center, McGill University, Montreal, QC, Canada
3Division of Nephrology, Department of Medicine, McGill University Health Center, McGill University, Montreal, QC, Canada
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.08.040How to use a DOI?
Abstract

Objectives: Hemodialysis patients are at greater risk of increased arterial stiffness. Regular aerobic exercise has been shown to reduce arterial stiffness in hemodialysis patients. However, the impact of a more realistic intradialytic form of exercise, such as pedaling, is unclear. Therefore, we aimed to examine 1) the effect of intradialytic pedaling exercise on arterial stiffness over 4 months, and 2) the durability of the pedaling effect 4 months after finishing the exercise intervention.

Methods: We performed a 4-month randomized control trial in patients on a stable in-center hemodialysis regimen (3 days/week). Subjects were block randomized to either pedaling exercise (EX) or to a control group receiving usual dialysis (nonEX) for 4 months. At baseline and 4 months, augmentation index heart rate corrected (AIx75), and carotid-femoral pulse wave velocity (cfPWV) were assessed (applanation tonometry; SphygmoCor XCEL). Measurements were repeated in the EX group 4 months after the exercise intervention.

Results: 11 exercisers (58±16 years, BMI 26±5kg/m2, 3 female) and 10 controls (53±15 years, BMI 27±6kg/m2, 3 female) were included. Overall exercise compliance was 60±25%, and subjects exercised on average 47±25 mins per session. AIx75 was unchanged in the EX group, however an increase of 4.4±4.5% was noted in the nonEX group (P=0.020). We observed a greater absolute decrease in cfPWV in the EX group compared to the nonEX group: -1.44±2.06 vs. 0.27±0.55 m/s (P=0.037) (Figure 1). This difference in cfPWV was maintained after adjustments for age, Charlson comorbidity score, and the baseline cfPWV value (P=0.041). Interestingly, the decrease in cfPWV observed in the EX group was partially preserved 4 months after exercise cessation (Figure 2).

Conclusions: The relationship between intradialytic pedaling exercise and improved arterial stiffness is promising, and warrants further investigation. Moreover, we have demonstrated that pedaling exercise is a realistic form of aerobic training in hemodialysis patients.

Figure 1

Post-exercise absolute change in cfPWV.

Figure 2

cfPWV at baseline, post-exercise and 4 months after exercise cessation.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
99 - 100
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.08.040How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Alexandra B. Cooke
AU  - Vincent Ta
AU  - Yessica-Haydee Gomez
AU  - Sameena Iqbal
AU  - Stella S. Daskalopoulou
PY  - 2016
DA  - 2016/11/24
TI  - PO-37 THE IMPACT OF INTRADIALYTIC PEDALING EXERCISE ON ARTERIAL STIFFNESS IN A HEMODIALYSIS POPULATION
JO  - Artery Research
SP  - 99
EP  - 100
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.08.040
DO  - 10.1016/j.artres.2016.08.040
ID  - Cooke2016
ER  -