11.6 THE AORTIC-TO-BRACHIAL STIFFNESS GRADIENT AND AORTIC RESERVOIR-EXCESS PRESSURE IN A DIALYSIS POPULATION

DOI

10.1016/j.artres.2016.10.094How to use a DOI?

Abstract

Background: Aortic reservoir function is associated with increased cardiovascular events. Patients with chronic kidney disease in need of dialysis have increased aortic stiffness and reversal of the aortic-to-brachial stiffness gradient, which could impair aortic reservoir function. The aim of this study was to determine the relationship between the aortic-to-brachial stiffness gradient and aortic reservoir function.

Methods: Among 310 patients with chronic kidney disease on dialysis, aortic and brachial stiffness were measured by pulse wave velocity (PWV), with the aortic-to-brachial stiffness gradient calculated by the ratio of aortic and brachial PWV (PWV ratio). Aortic reservoir function was measured by radial tonometry-derived reservoir pressure (RP) and excess pressure (XSP) integrals.

Results: RP was significantly and positively associated with PWV ratio (Standardized β=0.168 p<0.001) independent from age, sex, height, mean blood pressure, heart rate, treatment by hemodialysis and diabetes status (Model adjusted R²=0.68 p<0.001). On the other hand, XSP, which was significantly correlated to PWV ratio (Standardized β=0.20 p<0.001), lost its relation in multivariable adjusted model, and instead was predicted by age, heart rate, mean blood pressure and diabetes status, but this was only a weak model (Adjusted R²=0.15 p<0.001).

Conclusion: Among patients with chronic kidney disease on dialysis, the aortic-to-brachial stiffness gradient is an independent predictor of adverse aortic reservoir function.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Catherine Fortier
AU  - Marie-Pier Desjardins
AU  - Aboubacar Sidibe
AU  - Mathieu Allard
AU  - Martin G. Schultz
AU  - James E. Sharman
AU  - Mohsen Agharazii
PY  - 2016
DA  - 2016/11/24
TI  - 11.6 THE AORTIC-TO-BRACHIAL STIFFNESS GRADIENT AND AORTIC RESERVOIR-EXCESS PRESSURE IN A DIALYSIS POPULATION
JO  - Artery Research
SP  - 75
EP  - 75
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.094
DO  - 10.1016/j.artres.2016.10.094
ID  - Fortier2016
ER  -