Artery Research

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Volume 16, Issue C, December 2016, Pages 78 - 78

12.7 THE RELATIONSHIP BETWEEN FUNCTIONAL ARTERIAL RESPONSE AND CIRCULATING BIOMARKERS OF PATIENTS WITH FIBROMUSCULAR DYSPLASIA

Authors
Thi-Phuong-Nhung Hoang1, Pierre Boutouyrie4, Hakim Hettab2, Louise Marais1, Aurelien Lorthioir4, Michael Frank4, Ralph Niarra4, Jean-Marie Renard2, Yann Chambon2, Xavier Jeunemaitre3, Pierre-François Plouin3, Stéphane Laurent4, Chantal Boulanger1, Michel Azizi4
1University Paris Descartes, Paris, France
2INSERM U970 Paris Cardiovascular Research Center, Paris, France
3Clinical Investigation Center, Paris, France
4Department of Genetics and Hypertension Unit, Paris, France
Available Online 24 November 2016.
DOI
10.1016/j.artres.2016.10.105How to use a DOI?
Abstract

Background: Fibromuscular dysplasia (FMD) is a rare idiopathic, non-atherosclerotic non-inflammatory vascular disease. This work represents the first study of the pathophysiology of FMD. We investigated the relationships between circulating biomarkers and the non-invasive vascular parameters.

Methods: We included 50 patients with FMD, 50 essential hypertensive patients (HT) and 50 healthy subjects (NT) matched for age, sex, ethnicity and blood pressure. We determined circulating levels of total microparticles (MPs) (annexinV+MPs), endothelial MPs (CD144+MPs, CD62E+MPs and CD31+CD41-MPs) and SMC-MPs by flow cytometry analysis. We measured forearm endothelial function by post-ischemic flow dependent vasodilation. Shear stress was estimated using the formula of Weaver (1–3). Aortic stiffness was assessed by measuring carotid-femoral pulse wave velocity. Triple signal score was assessed from 15-MHz echotracking system.

Results: There are no significant differences between rates of total MPs, endothelial MPs (CD144+MPs, CD62E+MPs and CD31+CD41-MPs) and SMC-MPs between 3 groups (with p-value 0.38 0.52 0.65 0.17 and 0.25 respectively). Endothelial MPs were not correlated with the endothelial dysfunction, nor with the shear stress, whether in FMD, NT or HT. We observed a strong negative correlation between aortic stiffness and nitroglycerin-mediated dilation in the group NT, HT and whole population (r= −0.43, p= 0.001 r= −0.29, p= 0.03 r = −0.35, p<0.001 respectively), but not in FD (p=0.5). SMC-MPs were not associated with the triple signal or any arterial parameter in the group FMD nor in the whole population.

Conclusions: The number of MPs was not correlated with large artery properties. Arterial stiffness is negatively related to endothelium-independent dilatation.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
16 - C
Pages
78 - 78
Publication Date
2016/11/24
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2016.10.105How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - Thi-Phuong-Nhung Hoang
AU  - Pierre Boutouyrie
AU  - Hakim Hettab
AU  - Louise Marais
AU  - Aurelien Lorthioir
AU  - Michael Frank
AU  - Ralph Niarra
AU  - Jean-Marie Renard
AU  - Yann Chambon
AU  - Xavier Jeunemaitre
AU  - Pierre-François Plouin
AU  - Stéphane Laurent
AU  - Chantal Boulanger
AU  - Michel Azizi
PY  - 2016
DA  - 2016/11/24
TI  - 12.7 THE RELATIONSHIP BETWEEN FUNCTIONAL ARTERIAL RESPONSE AND CIRCULATING BIOMARKERS OF PATIENTS WITH FIBROMUSCULAR DYSPLASIA
JO  - Artery Research
SP  - 78
EP  - 78
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.105
DO  - 10.1016/j.artres.2016.10.105
ID  - Hoang2016
ER  -