11.10 ARTERIAL ELASTANCE IS ASSOCIATED WITH CENTRAL BLOOD PRESSURE AND ARTERIAL PERIPHERAL RESISTANCE IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION

DOI

10.1016/j.artres.2016.10.098How to use a DOI?

Abstract

Objective of the study was to assess ventricular-arterial coupling (VAC), parameters of left ventricular (LV) work efficiency and their determinants in patients with arterial hypertension (HTN) and stable heart failure with reduced ejection fraction (HFrEF).

Methods: In 93 stable patients with HTN and HFrEF 2-dimentional echocardiography was used to assess arterial elastance (Ea) and end systolic LV elastance (Ees). VAC was assessed as the ratio Ea/Ees. Mann-Witney test and multivariate analysis was performed. P<0.05 was considered significant.

Results: The range of VAC was 0.9–4.7. VAC >1.2 (upper optimal level) was revealed in 87%. Ea positively correlated with aortic systolic BP, office diastolic BP, arterial peripheral resistance, systole duration, negatively – with body mass index (BMI). Ees positively correlated with EF, office systolic and diastolic BP, negatively – with LV mass index (LVMI). Increased VAC was associated with decrease of office and aortic systolic BP, BMI, LV EF, increase of LVMI and NT-proBNP.

Conclusions: Impairment of functioning of cardio-vascular system assessed by increased value of VAC> 1.2 was revealed in 87% of patients with HTN and stable HFrEF. Increase of VAC was associated predominantly with decrease of Ees and LV work efficiency (SW/PVA). In HFrEF LV and arterial system matched to maximize SW. VAC and its components are associated with echocardiographic parameters and markers of arterial stiffness.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Evgeny Tyukhmenev
AU  - Svetlana Villevalde
AU  - Zhanna Kobalava
PY  - 2016
DA  - 2016/11/24
TI  - 11.10 ARTERIAL ELASTANCE IS ASSOCIATED WITH CENTRAL BLOOD PRESSURE AND ARTERIAL PERIPHERAL RESISTANCE IN PATIENTS WITH HEART FAILURE WITH REDUCED EJECTION FRACTION
JO  - Artery Research
SP  - 76
EP  - 76
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.098
DO  - 10.1016/j.artres.2016.10.098
ID  - Tyukhmenev2016
ER  -