6.6 AORTIC-BRACHIAL STIFFNESS MISMATCH IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS

DOI

10.1016/j.artres.2016.10.042How to use a DOI?

Abstract

Background: Patients with type 2 diabetes have a high risk of CVD. Arterial stiffness gradient is a new prognostic predictor of mortality previously assessed only in dialysis population^1–2.

The aim of the study was to assess arterial stiffness and stiffness gradient in diabetic patients with arterial hypertension (AH).

Methods: The study included 55 patients with AH and DM (38% male, mean age 61.6±12.7 years), mean office BP 142.5±25.5/82.7±10.7mmHg. All patients receive combination antihypertensive therapy, 7.27% of patients received statins. Target BP values (<140/85 mmHg) were achieved in 52.7% of patients. Target HbA1c levels were achieved in 10.9% of patients. Carotid-femoral (CF) and carotid-radial (CR) PWV were assessed and increased arterial stiffness was defined as an elevation of pulse pressure (PP)>60 mmHg,PWV>10 m/s. Stiffness gradient was assessed by CF-PWV/CR-PWV ratio, with values>1 indicating the stiffness mismatch.p<0.05 was considered significant.

Results: Mean PP was 47.6±12.7mmHg. PP>60mmHg was observed in 18,1%.Group with PP>60 mmHg was characterized by higher HbA1c (9.8±1.8vs8.4±2.0%) and stiffness gradient (1.4±0.4vs1.2±0.1)p<0.05 for trend. Mean CR-PWV was 7.7±1.2 m/s, mean CF-PWV was 10.3±2.0 m/s. CF-PWV>10m/s was observed in 27.2% of patients. Groups with PWV above and below 10m/s were similar by age, gender, metabolic risk factors and haemodynamic parameters. Mean stiffness gradient was 1.3±0.4, gradient >1 was observed in 92,7%. Patients with high stiffness gradient were older (63.3±11.6vs54.0±10.2,p<0.05). All other parameters were similar.

Conclusion: Patients with AH and type 2DM are characterized by aortic-brachial stiffness mismatch. Thus it can be used as early marker of vascular ageing in this patients’ population.

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TY  - JOUR
AU  - Ekaterina Starostina
AU  - Elena Troitskaya
AU  - Yulia Kotovskaya
AU  - Zhanna Kobalava
PY  - 2016
DA  - 2016/11/24
TI  - 6.6 AORTIC-BRACHIAL STIFFNESS MISMATCH IN PATIENTS WITH ARTERIAL HYPERTENSION AND TYPE 2 DIABETES MELLITUS
JO  - Artery Research
SP  - 60
EP  - 61
VL  - 16
IS  - C
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2016.10.042
DO  - 10.1016/j.artres.2016.10.042
ID  - Starostina2016
ER  -