Artery Research

Background: Essential hypertension is characterised by alterations in haemodynamics. Hence haemodynamic profiling could lead to improved blood pressure (BP) control in these patients. We tested if baseline haemodynamic indices predict the BP lowering effects of different classes of antihypertensive drugs...

Background. Experimental cerebral ischemia and organ culture of cerebral arteries result in enhanced expression of endothelin ETB receptors in smooth muscle cells. The present study was designed to evaluate the involvement of calcium-calmodulin dependent protein kinase (CAMK) on the expression of endothelin...

An age-related increase in systolic blood pressure and similarities in the consequences of hypertension and aging on arterial structure/mechanics have been reported, particularly in larger arteries. As the structural/mechanical properties of smaller resistance vessels in the context of advancing physiological...

To define the vascular role of the mineralocorticoid receptor (MR) in cardiovascular pathophysiology, we generated a conditional transgenic mouse model with MR overexpression in the endothelium. We previously described increase sensitivity to several vasoconstrictors in mesenteric arteries such as in...

Low serum vitamin D is linked with higher vascular risk. It is unclear how. Objective: to test whether 1,25(OH)2D3 (active vitamin D) modifies contractility of proximal resistance vessels, dose-dependently. Methods: Male Wistar rat mesenteric arteries were investigated by wire myography. 60mM High...

In Type 1 and 2 diabetes tissue stiffening is evident from measurements of the gross mechanical properties of the vasculature. In general, pathological glycosylation of extracellular matrix proteins may play an important role in increasing stiffness in diabetic patients. However, the effects of diabetes...

Epidemiologic studies have clearly demonstrated that cardiovascular risk is not only determined by conventional risk factors of importance in adult life, but also by early life events resulting of re-settings of key physiological functions. In our model of rats exposed in utero to maternal diabetes,...

The light energy absorption of whole blood in the visible and infrared range is partly caused by the oxidized and reduced haemoglobin. The measurement principle can be applied for photoplethysmography (PPG). Our PPG measures the blood flux in human vessels with means of red and infrared light absorption....

Vascular calcification (VC) has been sporadically reported in horses, but little is known regarding cause, pathogenesis and clinical significance. We hypothesized that in horses, structural and molecular changes may occur during VC that are comparable to human and mouse models. We surveyed Thoroughbred...

Background: Augmentation index (AIx) is regarded as a marker of systemic arterial stiffness. Patients with type 2 diabetes mellitus (T2DM) have increased arterial stiffness, but not AIx, which suggests that mechanisms contributing to AIx in T2DM may differ from healthy individuals and be unrelated to...

Background: Sex differences in arterial stiffness and wave reflections may lead to disproportionate increases in afterload and myocardial work in women. We examined sex differences in arterial stiffness, pressure from wave reflections, measures of left ventricular (LV) energetics and myocardial work. Methods:...

Apart from peculiarities of the cerebral circulation, required to perfuse the brain with the subject erect, the principles established for function of the human systemic circulation (pulsatile flow at input and steady flow at output in capillaries) are identical to those established for other mammals....