Artery Research

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Volume 8, Issue 4, December 2014, Pages 197 - 204

Sex differences in noninvasive estimates of left ventricular pressure energetics but not myocardial oxygen demand in young adults

Authors
William E. Hughes, Nicole L. Spartano, Wesley K. Lefferts, Jaqueline A. Augustine, Kevin S. Heffernan*
Department of Exercise Science, Syracuse University, Syracuse, NY, USA
*Corresponding author. The Human Performance Laboratory, Department of Exercise Science, Syracuse University, Syracuse, NY, 13244, USA. E-mail address: ksheffer@syr.edu (K.S.Heffernan).
Corresponding Author
Kevin S. Heffernan
Received 25 April 2014, Accepted 30 July 2014, Available Online 28 August 2014.
DOI
10.1016/j.artres.2014.07.003How to use a DOI?
Keywords
Pressure wave reflections; Blood pressure; Women; Pulse wave analysis
Abstract

Background: Sex differences in arterial stiffness and wave reflections may lead to disproportionate increases in afterload and myocardial work in women. We examined sex differences in arterial stiffness, pressure from wave reflections, measures of left ventricular (LV) energetics and myocardial work.

Methods: 99 Healthy adults participated in this study 84 were selected (42 females, 42 males) to be matched for potential confounders of central hemodynamic burden such as age, BMI, and mean arterial pressure. Aortic pressure waves were derived from the radial artery using a generalized transfer function. Pulse contour analysis and wave separation analysis were used to obtain: pulse wave velocity (PWV) as a measure of aortic stiffness, augmentation index (AIx) and reflection index (RIx) as measures of global wave reflections, LV pressure effort (ΔEw) as a measure of LV energy required to overcome wave reflections and the subendocardial viability ratio (SEVR) as a proxy of myocardial work.

Results: Women exhibited higher ΔEw (p < 0.05), heart rate corrected AIx (p < 0.05) and RIx (p < 0.01), and lower PWV (p < 0.001) compared to men. Pressure from wave reflections (Pb) was significantly associated with ΔEw in women (r = 0.81, p < 0.001), but not in men (r = 0.14, p > 0.05). There were no sex differences for SEVR (p = 0.4).

Conclusion: Women had higher pressure from wave reflections which was associated with greater LV pressure effort compared to men. Although women had increased LV pressure effort, proxies of myocardial perfusion and work were not affected.

Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
8 - 4
Pages
197 - 204
Publication Date
2014/08/28
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2014.07.003How to use a DOI?
Copyright
© 2014 Association for Research into Arterial Structure and Physiology. Published by Elsevier B.V. All rights reserved.
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - William E. Hughes
AU  - Nicole L. Spartano
AU  - Wesley K. Lefferts
AU  - Jaqueline A. Augustine
AU  - Kevin S. Heffernan
PY  - 2014
DA  - 2014/08/28
TI  - Sex differences in noninvasive estimates of left ventricular pressure energetics but not myocardial oxygen demand in young adults
JO  - Artery Research
SP  - 197
EP  - 204
VL  - 8
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2014.07.003
DO  - 10.1016/j.artres.2014.07.003
ID  - Hughes2014
ER  -