P11.15 ANGIOTENSIN CONVERTING ENZYME -2 (ACE-2) POLYMORPHISMS RS4646156 AND RS4646174 ARE ASSOCIATED WITH CENTRAL PULSE PRESSURE, BRAIN NATRIURETIC PEPTIDE AND NYHA CLASSIFICATION IN PATIENTS WITH CHRONIC HEART FAILURE
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The pulse pressure (PP) is an independent predictor of cardiovascular morbidity and mortality. The PP level increases with the age and this increase is due to stiffness of large arteries. Angiotensin I converting enzyme 2 cleaves angiotensin I to angiotensin - (1–7) with vasodilatation and antiproliferative effects. In human medicine, the ACE-2 relation to the pulse pressure has not been studied yet. The aim of the study was to test possible association among phenotypes (central pulse pressure evaluated by invasive method in stable patients with well-preserved systolic function of the left ventricle, BNP as a marker of a severity of the disease and NYHA classification) and genotypes in two polymorphisms of ACE–2 gene.
Methods: A group of 312 patients with chronic heart failure (170 men and 142 women, median age 63 years) was enrolled in the study. The rs4646156 and rs4646174 polymorphisms in ACE-2 gene were detected by Tasman SNP genotyping.
Results: The central pulse pressure was highly significantly correlated with BNP, NT- proBNP and big endothelin levels. We observed significant differences in central pulse pressure among carriers of different genotypes of both ACE-2 polymorphisms (P=0.01 and 0.03, respectively). For the heterozygote genotype AT (rs4646156) a and CG (rs46461745) we report the higher risk for women in all NYHA groups compared to men (P<0.04–0.000001) with average sensitivity of 0.550 and specify of 0.980.
Conclusion: The heterozygote genotypes in ACE-2 polymorphisms are more risky for women with chronic heart failure compared to men.
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TY - JOUR AU - A. Vašků AU - J. Pařenica AU - M. Pávková-Goldbergová AU - P. Kala AU - M. Poloczek AU - J. Špinar PY - 2011 DA - 2011/11/29 TI - P11.15 ANGIOTENSIN CONVERTING ENZYME -2 (ACE-2) POLYMORPHISMS RS4646156 AND RS4646174 ARE ASSOCIATED WITH CENTRAL PULSE PRESSURE, BRAIN NATRIURETIC PEPTIDE AND NYHA CLASSIFICATION IN PATIENTS WITH CHRONIC HEART FAILURE JO - Artery Research SP - 196 EP - 196 VL - 5 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2011.10.171 DO - 10.1016/j.artres.2011.10.171 ID - Vašků2011 ER -