P11.30 HERITABILITY OF CENTRAL BLOOD PRESSURE AND PULSE PRESSURE – A TWIN STUDY

A.D. Tarnoki; D.L. Tarnoki; M.A. Stazi; E. Medda; R. Cotichini; L. Nistico; P. Lucatelli; E. Boatta; C. Zini; F. Fanelli; C. Baracchini; G. Meneghetti; G. Schillaci; G. Jermendy; J. Osztovits; A. Lannert; A.A. Molnar; L. Littvay; Z. Garami; V. Berczi

doi:10.1016/j.artres.2011.10.184

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Volume 5, Issue 4, December 2011, Pages 200 - 200

P11.30 HERITABILITY OF CENTRAL BLOOD PRESSURE AND PULSE PRESSURE – A TWIN STUDY

Authors

A.D. Tarnoki¹, D.L. Tarnoki¹, M.A. Stazi², E. Medda², R. Cotichini², L. Nistico², P. Lucatelli³, E. Boatta³, C. Zini³, F. Fanelli³, C. Baracchini⁴, G. Meneghetti⁴, G. Schillaci⁵, G. Jermendy⁶, J. Osztovits⁶, A. Lannert⁷, A.A. Molnar⁸, L. Littvay⁹, Z. Garami¹⁰, V. Berczi¹

¹Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary

²Genetic Epidemiology Unit, National Centre of Epidemiology, Istituto Superiore di Sanità, Rome, Italy

³Vascular and Interventional Radiology Unit, Department of Radiological Sciences, La Sapienza University of Rome, Rome, Italy

⁴Department of Neurosciences, University of Padua School of Medicine, Padua, Italy

⁵Unit of Internal Medicine, Angiology&Arteriosclerosis Disease, Dept.of Clinical and Experimental Medicine, Univ. of Perugia, Perugia, Italy

⁶Bajcsy Zsilinszky Hospital, 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

⁷Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of Sciences and Semmelweis University, Budapest, Hungary

⁸Faculty of Pharmacy, Semmelweis University, Budapest, Hungary

⁹Central European University, Budapest, Hungary

¹⁰The Methodist Hospital DeBakey Heart and Vascular Center, Houston, TX, United States of America

Available Online 29 November 2011.

DOI: 10.1016/j.artres.2011.10.184 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Objective: Central blood pressure (SBP_ao), peripheral and aortic pulse pressure (PP, PP_ao) are powerful predictor of cardiovascular events. No comprehensive twin study has investigated their heritabilities.

Methods: 389 Italian, Hungarian and American twin pairs (230 monozygotic and 159 dizygotic) underwent oscillometric arterial stiffness investigation (TensioMed Arteriograph, TensioMed Ltd., Budapest) to measure brachial and aortic augmentation index (Aix_bra,, Aix_ao), pulse wave velocity on aorta (PWV_ao) and SBP_ao. MPlus Version6 statistical softwer was used.

Results: Age, sex and country-adjusted heritability of SBP_ao, PP and PP_ao indicated 45.5% (95% confidence interval /CI/, 10.5 to 60.0%), 46.6% (95% CI, 29.8 to 58.0%), and 39.9% (95% CI, 1.4 to 53.9%). Unshared environmental effects accounted for the largest part of variance, respectively. Model fit was normal. Bivariate saturated model showed high and significant correlations between SBP_ao, PP_ao and arterial stiffness measures (r=0.588, p<0.001 between SBP_ao and Aix_bra; r=0.587, p<0.001 between SBP_ao and Aix_ao; r=0.475, p<0.001 between SBP_ao and PWV_ao; r=0.582, p<0.001 between PP_ao and Aix_bra; r=0.581, p<0.001 between PP_ao and Aix_ao; r=0.456, p<0.001 between PP_ao and PWV_ao). Non-significant correlations were estimated for PP and Aix (r=−0.077, p=0.057 between PP and Aix_bra; r=−0.078, p=0.055 between PP and Aix_ao; r=0.083, p<0.05 between PP and PWV_ao).

Conclusions: SBP_ao, PP and PP_ao are moderately heritable. High significant correlations were estimated between SBP_ao, PP_ao and arterial stiffness, suggesting a genetic background.

(The research was supported by Medexpert Ltd, Twins Days Festival Committee, Balassa Institute Hungarian Scholarship Board Office, Ministry for Foreign Affairs of Republic of Italy.)

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Journal: Artery Research
Volume-Issue: 5 - 4
Pages: 200 - 200
Publication Date: 2011/11/29
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2011.10.184 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

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ris enw bib

TY  - JOUR
AU  - A.D. Tarnoki
AU  - D.L. Tarnoki
AU  - M.A. Stazi
AU  - E. Medda
AU  - R. Cotichini
AU  - L. Nistico
AU  - P. Lucatelli
AU  - E. Boatta
AU  - C. Zini
AU  - F. Fanelli
AU  - C. Baracchini
AU  - G. Meneghetti
AU  - G. Schillaci
AU  - G. Jermendy
AU  - J. Osztovits
AU  - A. Lannert
AU  - A.A. Molnar
AU  - L. Littvay
AU  - Z. Garami
AU  - V. Berczi
PY  - 2011
DA  - 2011/11/29
TI  - P11.30 HERITABILITY OF CENTRAL BLOOD PRESSURE AND PULSE PRESSURE – A TWIN STUDY
JO  - Artery Research
SP  - 200
EP  - 200
VL  - 5
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2011.10.184
DO  - 10.1016/j.artres.2011.10.184
ID  - Tarnoki2011
ER  -

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