P4.52 CORONARY ARTERY DISEASE AND STROKE IN TYPE 2 DIABETIC PATIENTS: POSSIBLE ROLE OF A RAISED CENTRAL PULSE PRESSURE

C. Palombo; C. Morizzo; G. Bini; C. Bianchi; E. Venturi; R. Miccoli; A. Natali; M. Kozakova

doi:10.1016/j.artres.2012.09.199

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Volume 6, Issue 4, December 2012, Pages 197 - 197

P4.52 CORONARY ARTERY DISEASE AND STROKE IN TYPE 2 DIABETIC PATIENTS: POSSIBLE ROLE OF A RAISED CENTRAL PULSE PRESSURE

Authors

C. Palombo¹, C. Morizzo¹, G. Bini¹, C. Bianchi¹, E. Venturi¹, R. Miccoli¹, A. Natali¹, M. Kozakova¹^{, 2}

¹University of Pisa, Pisa, Italy

²Esaote SpA, Genova, Italy

Available Online 17 November 2012.

DOI: 10.1016/j.artres.2012.09.199 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Background: Whether large artery static and dynamic properties are different in type 2 diabetics with coronary or cerebrovascular disease (DM-CVD) as compared to patients free of clinical complications (DM) is debated.

Aim: To evaluate common carotid (CCA) IMT, local and aortic stiffness in DM-CVD as compared to DM and controls (CTRL).

Methods: thirty-five nondiabetic normotensive CTRL, 130 diabetics without complications (DM) and 25 diabetics with CAD and/or previous stroke/TIA (DM-CVD) (Tab 1) underwent radiofrequency (RF)-based ultrasound (QIMT® and QAS®, Esaote) of CCA, that provides automatic measurement of far-wall IMT, local stiffness (β-index) and contour wave analysis yielding local pulse pressure (PPc). Carotid-femoral pulse-wave velocity (PWV) was also measured (Complior).

Groups	Age	BMI	Glycemia	SBPb	PPb
CTRL	56±8^*	26±4^*	88±10^*	123±12^*	46±8^*
DM	62±8	29±5	146±42	136±18	57±16
DM-CVD	66±7	29±4	138±42	136±23	62±18

Results: Adjusting for sex, age and smoking habit, CTRL and diabetics differed significantly (p<0.05) in PWV (9.0±1.9 vs. 11.4±2.5 m/s), CCA IMT (619±146 vs. 736±169 μm) and PPc (37±9 vs. 46±14 mmHg), but not in β-index (10.1±2.9 vs. 12.5±4.9; p=0.23). Within diabetics, after adjustment for confounders, DM-CVD showed higher (p<at least 0.05) PPc but not CCA IMT, β-index and brachial PP (PPb) than DM (Tab 2).

Groups	PWV	IMT	β-index	SBPc	PPc
CTRL	9.0±1.9^*	619±146^*	10.1±2.9^*	115±12^*	37±9^*
DM	11.3±2.4	726±173	12.4±4.3	123±16	44±13^°
DM-CVD	12.0±3.5	794±129	14.6±6.8	127±19	52±16

*:

p<0.05 in CTRL vs DM and DM-CVD;

°:

p< 0.05 in DM vs DM-CVD

Conclusions: central PP appears to be the only structural/functional large artery measure significantly different in diabetic patients with or without cardiovascular complications, despite similar glucose levels and BMI. Contour wave analysis by ultrasound provides additional information beyond IMT and local stiffness indices.

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Journal: Artery Research
Volume-Issue: 6 - 4
Pages: 197 - 197
Publication Date: 2012/11/17
ISSN (Online): 1876-4401
ISSN (Print): 1872-9312
DOI: 10.1016/j.artres.2012.09.199 How to use a DOI?
Open Access: This is an open access article distributed under the CC BY-NC license.

Cite this article

ris enw bib

TY  - JOUR
AU  - C. Palombo
AU  - C. Morizzo
AU  - G. Bini
AU  - C. Bianchi
AU  - E. Venturi
AU  - R. Miccoli
AU  - A. Natali
AU  - M. Kozakova
PY  - 2012
DA  - 2012/11/17
TI  - P4.52 CORONARY ARTERY DISEASE AND STROKE IN TYPE 2 DIABETIC PATIENTS: POSSIBLE ROLE OF A RAISED CENTRAL PULSE PRESSURE
JO  - Artery Research
SP  - 197
EP  - 197
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.199
DO  - 10.1016/j.artres.2012.09.199
ID  - Palombo2012
ER  -

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