Artery Research

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Volume 6, Issue 4, December 2012, Pages 194 - 194

P4.38 LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 PREDICTS CORONARY ARTERY CALCIFICATION ASSESSED BY MULTISLICE COMPUTED TOMOGRAPHY

Authors
E. Kaczmarska, Z. Dzielinska, Z. Bilinska, C. Kepka, R. Pracon, K. Kryczka, J. Pregowski, M. Kruk, M. Demkow
Institute of Cardiology, Warsaw, Poland
Available Online 17 November 2012.
DOI
10.1016/j.artres.2012.09.185How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Background: Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) has been shown to be a highly specific biomarker for artery inflammation and for cardiovascular risk assessment. Coronary artery calcification defined as coronary artery calcium score (CAC score) is a marker of increased risk of coronary artery disease (CAD).

Aim: This study evaluates the association between Lp-PLA2 and presence of coronary artery calcification among patients with low and intermediate probability of CAD.

Methods: The analysis included 305 consecutive patients (61.3±10.59 yrs; 41.3% males) with intermediate probability of CAD. All patients were routinely assessed for traditional risk factors of CAD. Serum Lp-PLA2 mass was measured by ELISA-based method. CAC score was obtained by multi-detector computed tomography and calculated by Agatston method. Coronary artery calcification was defined as CAC score>0.

Results: Clinical characteristic of study population is summarized in the table. Coronary artery calcification was found in 187 (61.3%) patients (63.76±9.94 yrs; 48.7% males). In univariate analysis the predictors of coronary artery calcification were age (OR 1.07, 95%CI 1.04–1.09, p<0.0001), male gender (OR 2.42, 95%CI 1.38–3.66, p=0.0011), hypertension (OR 4.76, 95%CI 1.26–18.06, p=0.0217), diabetes (OR 4.28, 95%CI 1.37–13.36, p=0.0123), Lp-PLA2 (OR 1.008, 95%CI 1.0006–1.014, p=0.0325), eGFR (OR 0.97, 95%CI 0.955–0.99, p=0.0042), triglycerides (OR 1.55, 95%CI 1.03–2.32, p=0.0362). In multivariate analysis age (OR 1.08, 95%CI 1.02–1.12, p=0.0055) and Lp-PLA2 (OR 1.02, 95%CI 1.004–1.03, p=0.01) were the only independent predictors of coronary artery calcification.

Conclusions: Plasma Lp-PLA2 is independently related to coronary artery calcification which supports its potential clinical utility in identification of individuals at increased risk of CAD.

Hypertension, (%) 41.9
Hyperlipidemia, (%) 40.6
Diabetes (%) 7.5
Smoking history (%) 24.6
Family history of CAD (%) 23.6
CAC score (mean±SD) 193±413.2
Lp-PLA2 (ng/ml, mean±SD) 179.7±36.8
C-reactive protein (mg/dl, mean±SD) 0.23±0.34
eGFR (ml/min/1,73m2, mean±SD) 75.72±13.21
HDL (mmol/l, mean±SD) 1.66±1.87
Triglycerides (mmol/l, mean±SD) 1.27±0.68
LDL(mmol/l, mean±SD) 3.00±1.67
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Journal
Artery Research
Volume-Issue
6 - 4
Pages
194 - 194
Publication Date
2012/11/17
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.1016/j.artres.2012.09.185How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

risenwbib
TY  - JOUR
AU  - E. Kaczmarska
AU  - Z. Dzielinska
AU  - Z. Bilinska
AU  - C. Kepka
AU  - R. Pracon
AU  - K. Kryczka
AU  - J. Pregowski
AU  - M. Kruk
AU  - M. Demkow
PY  - 2012
DA  - 2012/11/17
TI  - P4.38 LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 PREDICTS CORONARY ARTERY CALCIFICATION ASSESSED BY MULTISLICE COMPUTED TOMOGRAPHY
JO  - Artery Research
SP  - 194
EP  - 194
VL  - 6
IS  - 4
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2012.09.185
DO  - 10.1016/j.artres.2012.09.185
ID  - Kaczmarska2012
ER  -