P4.37 COMPARING THE ASSOCIATION OF CARDIOVASCULAR REACTIVITY AND END-ORGAN DAMAGE IN AFRICAN AND CAUCASIAN MEN: THE SABPA STUDY
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- 10.1016/j.artres.2012.09.184How to use a DOI?
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Objectives: The cardiovascular system was challenged to evaluate the possible contribution of vascular resistance and stroke volume (SV) reactivity on left ventricular mass and intima-media thickness, in both African and Caucasian men. Increased afterload as a result of increased vascular resistance may lead to impaired stroke volume and vascular and/or ventricular hypertrophy.
Methods: We included 101 African and 101 Caucasian men. Ambulatory 24-hour blood pressure measurements were conducted. Vascular resistance, compliance (Cwk) and stroke volume resting and reactivity values were obtained during the application of the Stroop color word conflict test. Left ventricular mass was determined using the Cornell product. The carotid-IMT was obtained and the cross-sectional wall area (CSWA) calculated. PWV was measured.
Results: In African men it was found, besides higher blood pressure, PWV and Cornell product values, that vascular resistance showed higher resting values as well as positive reactivity values, compared to Caucasian men. Vascular compliance and stroke volume reactivity was suppressed in African men. Diastolic blood pressure reactivity was also higher in Africans. Stroke volume showed a consisted association with markers of end-organ damage only in African men, namely with left ventricular mass and CSWA in partial and multiple regression analysis (Table 1).
| CSWA (mm2) | Cornell product (mV) | |||||
|---|---|---|---|---|---|---|
| variables | Adj.R2 | β ± (SE) | P | Adj.R2 | β ± (SE) | P |
| SBP % | 0.238 | 0.115 ± 0.09 | 0.225 | 0.138 | 0.06 ± 0.13 | 0.64 |
| DBP % | 0.267 | 0.208 ± 0.09 | 0.027 | 0.168- | 0.206 ± 0.11 | 0.055 |
| SV % | 0.284 | −0.240 ± 0.09 | 0.008 | 0.178 | −0.212 ± 0.10 | 0.039 |
| Cwk % | 0.246 | −0.219 ± 0.09 | 0.023 | 0.171 | −0.196 ± 0.10 | 0.059 |
Multiple regression of CSWA and Cornell product in Africans.
Conclusion: African men showed an increased vascular resistance reactivity accompanied by an impaired stroke volume reactivity, that indicate restricted ventricular function. For the same age the African men showed impaired ventricular function and vascular hypertrophy.
Cite this article
TY - JOUR AU - H.W. Huisman AU - A.E. Schutte AU - R. Schutte AU - J.M. Van Rooyen AU - N.T. Malan AU - W. Smith AU - C.M.T. Fourie AU - C. Mels AU - R. Kruger AU - L. Malan PY - 2012 DA - 2012/11/17 TI - P4.37 COMPARING THE ASSOCIATION OF CARDIOVASCULAR REACTIVITY AND END-ORGAN DAMAGE IN AFRICAN AND CAUCASIAN MEN: THE SABPA STUDY JO - Artery Research SP - 193 EP - 193 VL - 6 IS - 4 SN - 1876-4401 UR - https://doi.org/10.1016/j.artres.2012.09.184 DO - 10.1016/j.artres.2012.09.184 ID - Huisman2012 ER -