Artery Research
Volume 3, Issue 3, September 2009
2. 1. ACUTE INFLAMMATION INCREASES ARTERIAL STIFFNESS, CENTRAL SYSTOLIC BLOOD PRESSURE, AND ENDOTHELIAL DYSFUNCTION IN HEALTHY SUBJECTS
Sae Young Jae, Kevin S. Heffernan, Bo Fernhall
Pages: 92 - 92
Background: Acute systemic inflammation or infection transiently increases risk of cardiovascular events, but the underlying mechanisms are not fully understood. Although observational studies suggest that inflammation is positively associated with arterial stiffness and blood pressure, the causal relationship...
3. 3. ESTIMATION OF CORONARY FLOW RESERVE CAPACITY USING TRANSTHORACIC DOPPLER ECHOCARDIOGRAPHY AND THE COLD PRESSOR TEST IS USEFUL FOR DIAGNOSING VARIANT ANGINA
Hee-Jung Hwang, Ho-Joong Youn, Yun-Seok Choi, Jae-Beom Lee, Woo-Baek Chung, Jong-Won Chung, Chul-Soo Park, Yong-Seog Oh, Wook-Sung Chung, Jae-Hyung Kim
Pages: 92 - 92
Background: The cold pressor test (CPT) has been used to detect vasospastic angina, but its sensitivity for predicting vasospasm is low. The aim of this study was to determine if the estimation of coronary flow reserve capacity in the left anterior descending coronary artery using transthoracic Doppler...
Conference Abstract
4. 2. DECELERATION TIME OF THE LEFT VENTRICULAR OUTFLOW TRACT FLOW VELOCITY: A SURROGATE DOPPLER ECHOCARDIOGRAPHIC PARAMETER FOR CENTRAL PULSE PRESSURE
Chi Young Shim, Sungha Park, Woo-in Yang, Sung-Ai Kim, Sang-Jae Rhee, Sun-Ha Moon, Hyun-Jin Lee, Jin-Mi Kim, Eui-Young Choi, Namsik Chung, Jong-Won Ha
Pages: 92 - 92
Background: Central pulse pressure (PP) is an independent predictor of cardiovascular outcomes. However, a Doppler echocardiographic parameter reflecting central PP and arterial stiffness is not known yet. The aim of this study was to evaluate whether the left ventricular outflow tract (LVOT) flow deceleration...
5. 5. THE EFFECT OF CILOSTAZOL TO ARTERIAL STIFFNESS IN THE HYPERTENSIVE PATIENT
Jin Oh Na, Chang-Gyu Park, Cheol-Ung Choi, Soon-Yong Suh, Eung-Ju Kim, Seung-Woon Rha, Jin-Won Kim, Hong-Seog Seo, Dong-Joo Oh
Pages: 93 - 93
Background: Cilostazol is a potent antiplatelet agent that selectively inhibits phosphodiesterase III, and also it has beneficial effect to peripheral arterial disease, like intermittent claudication, by direct vasodilative action. But the effect of cilostazol on arterial stiffness is unclear. We investigated...
6. 7. KOREAN PANAX RED GINSENG IMPROVES ENDOTHELIAL DYSFUNCTION AND ARTERIAL STIFFNESS IN PATIENTS WITH CORONARY ARTERY DISEASE PROBABLY BY DECREASING RHO-ASSOCIATED KINASE ACTIVITY OF PERIPHERAL BLOOD MONONUCLEAR CELLS
Ick-Mo Chung, Joo Weon Lim, Hae-Yun Chung, Jeong Yeon Seo, Gil-Ja Shin, Si-Hoon Park, Hyeyoung Kim
Pages: 93 - 93
Background: Korean Panax Red Ginseng (KPRG) is known to enhance endothelium-dependent vasorelaxation by activating eNOS. Activation of Rho-associated kinase (ROCK) is implicated in endothelial dysfunction in part through destabilization of eNOS mRNA. This study, a randomized, double-blind, placebo-controlled,...
Conference Abstract
7. 4. CAROTID FLOW VELOCITY DIFFERENCE AS A SURROGATE FOR ISCHEMIC STROKE
Hyun Ju Yoon, Min Gu Lee, Jum Seok Ko, Ju Han Kim, Younggeun Ahn, Myung Ho Jeong, Jung Gwan Cho, Jung Chaee Kang, Jong Chun Park
Pages: 93 - 93
Background: Carotid flow peak velocity is increased in carotid artery stenosis. Carotid intima-media thickness (IMT) have been associated with an increased risk of ischemic stroke. We performed this study to evaluate the relationship between carotid flow velocity and carotid IMT in ischemic stroke without...
Conference Abstract
8. 6. BERBERINE -INDUCED UPREGULATION OF CIRCULATING ENDOTHELIAL PROGENITOR CELLS IMPROVES ENDOTHELIAL FUNCTION AND ARTERIAL ELASTICITY IN HEALTHY SUBJECTS
Su Chen, Jun Tao
Pages: 93 - 93
Background: It has been proved that Berberine(BR) can improve endothelial function recently. However, the underlying mechanisms about the effect of berberine on endothelial function are not completely clear. The number and function of circulating endothelial progenitor cells(EPC) are involved in the...
9. 1. ARTERIAL STIFFNESS IN MASKED HYPERTENSION AND TRUE HYPERTENSION
Young-Soo Lee, Kee Sik Kim, Myung Jun Seung, Jung Hyun Kim, So-Yeon Kim, Jin-Bae Lee, Jae-Kean Ryu, Ji-Yong Choi, Kee-Sik Kim, Sung-Gug Chang
Pages: 94 - 94
Background: Masked hypertension (MH) has been drawing attention recently because this condition is often seen in untreated and treated individuals and is associated with target organ damage and a poor cardiovascular prognosis. Arterial stiffness is associated with organ damage in patients with primary...
10. 9. NORMAL VALUE OF COMMON CAROTID INTIMA-MEDIA THICKNESS IN KOREAN GENERAL POPULATION
Young Jin Youn, Jang-Young Kim, Kyung-Hoon Choe, Junghan Yoon, Seung-Hwan Lee, Kyounghoon Lee, Jun-Won Lee, Sang-Beak Koh, Jongku Park
Pages: 94 - 94
Background: Carotid intima-media thickness (CIMT) is a surrogate marker of cardiovascular disease (CVD). CIMT values ≥75th percentile of normal subjects are considered high and indicative of increased CVD risk. It is a rare data about normal CIMT values in Asian subjects without conventional CVD risk...
11. 8. EXAGGERATED BLOOD PRESSURE RESPONSE TO EXERCISE IS ASSOCIATED WITH ARTERIAL STIFFENING IN PRE-HYPERTENSIVE PATIENTS
Kyungdon Ryu, Young-Sub Byun, Byoung Kwon Lee, Choong-Won Goh, Kun-Joo Rhee
Pages: 94 - 94
Background: Individuals with a systolic BP of 120 to 139 mmHg or a diastolic BP of 80 to 89 mmHg should be considered as pre-hypertensive. however limited evidence exists on whether the early drug intervention is needed according to identification of other cardiovascular risk factors except diabetes....
Conference Abstract
12. 10. OXIDATIVE STRESS AND ARTERIAL STIFFNESS IN STRENGTH- AND ENDURANCE-TRAINED ATHLETES
Youngju Choi, Takeshi Otsuki, Asako Miyaki, Nobutake Shimojo, Mutsuko Yoshizawa, Maiko Misono, Hitoshi Shiraki, Ryuichi Ajisaka, Seiji Maeda
Pages: 94 - 94
Background: Endurance exercise training decreases arterial stiffness, whereas high-intensity strength exercise training increases arterial stiffness. However, the mechanisms underlying the different adaptations to these two types of exercise training are unclear. Oxidative stress induces vasoconstriction...
13. 2. INCREASED ARTERIAL STIFFNESS FOLLOWING ACUTE RESISTANCE EXERCISE IS ASSOCIATED WITH CHANGES IN AUTONOMIC TONE
Eun Sun Yoon, Su Jin Jung, Sung Kun Cheun, Kevin S. Heffernan, Sae Young Jae
Pages: 95 - 95
Background: Although acute and chronic resistance exercise is associated with increases in arterial stiffness, the underlying mechanisms are not completely understood. Autonomic nervous system function is associated with arterial stiffness. Therefore, the purpose of this study was to test the hypothesis...
14. 5. BRACHIAL-ANKLE AND REGIONAL PULSE WAVE VELOCITY AS A PROGNOSTIC IMPACT IN HYPERTENSION
Mitsuru Ohishi, Takashi Takagi, Miyuki Onishi, Yuji Tatara, Nozomi Kato, Hiromi Rakugi
Pages: 95 - 96
Background: Many reports have shown that brachial-ankle pulse wave velocity (baPWV) as well as carotid-femoral PWV would be one of the prognostic factors for hypertension. We can evaluate heart-carotid PWV (hcPWV), heart-femoral PWV (hfPWV), femoral-ankle PWV (faPWV) using carotid and femoral sensor...
15. 4. CORONARY CALCIUM SCORE, RATHER THAN CAROTID INTIMA-MEDIA THICKNESS, IS MORE PREDICTIVE OF CORONARY RESTENOSIS AFTER DES IMPLANTATION
Yun-Seok Choi, Ho-Joong Youn, Hee-Jung Hwang, Jae-Beom Lee, Woo-Baek Chung, Jong-Won Chung, Chul-Soo Park, Yong-Seog Oh, Sang-Hong Baek, Wook-Sung Chung, Ki-Bae Seung, Jae-Hyung Kim
Pages: 95 - 95
Background: Calcium scoring on MDCT and carotid intima-media thickness (IMT) have been widely used as indices of atherosclerosis. However, the clinical correlation between carotid IMT and the severity of coronary artery disease (CAD) is relatively poorly established. The aim of this study was to determine...
16. 3. MECHANISMS FOR AGE-CHANGE IN AORTIC AUGMENTATION PRESSURE
Michael F. O’Rourke, Mayooran Namasivayam, Audrey Adji
Pages: 95 - 95
Augmentation index (AIx) is a widely used measure of wave reflection and aortic stiffness. It rises with age in a curvilinear manner whereas central augmentation pressure (AP) and pulse pressure (PP) from which it is determined (as AIx=AP ÷ PP) rise linearly with age. Apparent flattening of AIx over...
17. 9. HMG-COA REDUCTASE INHIBITOR IMPROVES ENDOTHELIAL DYSFUNCTION IN SPONTANEOUS HYPERTENSIVE RATS VIA DOWN-REGULATION OF CAVEOLIN-1 AND ACTIVATION OF ENOS
Dong-Ju Choi, Eun-Ji Kim, Min-Jung Park, Jung-Won Suh, Hyuk-Jae Chang, Young-Seok Cho, Tae-Jin Yeon, In-Ho Chae, Kwang-Il Kim, Cheol-Ho Kim, Hyo-soo Kim, Buyng-Hee Oh, Young-Bae Park
Pages: 96 - 97
Hypertension is associated with endothelial dysfunction and increased cardiovascular risk. Caveolin-1 regulates nitric oxide(NO) signaling by modulating endothelial nitric oxide synthase(eNOS). The purpose of this study was to examine whether HMG-CoA reductase inhibitor improves impaired endothelial...
18. 8. USEFULNESS OF BRACHIAL-ANKLE AND CAROTID-FEMORAL PULSE WAVE VELOCITY AS PREDICTIVE VALUES OF CARDIOVASCULAR EVENTS
Takashi Takagi, Mitsuru Ohishi, Miyuki Onishi, Yuji Tatara, Hiromi Rakugi
Pages: 96 - 96
Background: The measurement of carotid-femoral pulse wave velocity (cfPWV) is useful to predict storke and cardiovascular events in hypetensive patients as our previous cohort study Non-invasive Atheroslerotic evaluation in Hypertension (NOAH) sutdy. As the cfPWV is useful, but not easy to measure, it...
19. 7. THE VALUE OF PULSE WAVE VELOCITY AS AN INDEX FOR THE PREDICTION OF CORONARY ATHEROSCLEROSIS
Won-woo Seo, IkSung Cho, Yeonyee E. Yoon, Jung-Won Suh, Kwang-Il Kim, Yong-Seok Cho, Tae-Jin Youn, In-Ho Chae, Dong-Ju Choi, Cheol-Ho Kim, Eun-J. Chun, Hyuk-Jae Chang
Pages: 96 - 96
Background: Arterial stiffness has been known as an independent contributory factor for coronary artery disease (CAD). Pulse wave velocity (PWV) is widely accepted as a simple non-invasive measure of arterial stiffness. The aim of our study was to test whether abnormal PWV could identify patients with...
20. 6. BRACHIAL-ANKLE PULSE WAVE VELOCITY AND CHRONIC KIDNEY DISEASE AS A PROGNOSTIC IMPACT IN HYPERTENSION
Miyuki Onishi, Mitsuru Ohishi, Takashi Takagi, Yuji Tatara, Nozomi Kato, Hiromi Rakugi
Pages: 96 - 96
Background: Many reports have shown that brachial-ankle pulse wave velocity (baPWV) has an effect on evaluation of atherosclerotic change and would be one of the prognostic factors for hypertension (HT). It has been reported that chronic kidney disease (CKD) would influence the prognosis of HT or diabetes...
21. 11. THE EFFECT OF LONG-TERM ADMINISTRATION OF HYDROCHLOROTHIAZIDE ON CENTRAL BLOOD PRESSURE
Yang Qian, Jiang Xiongjing, Zhang Yuqing, Liu Lisheng
Pages: 97 - 97
Background: It’s unknown wheather there is much benefit on central aortic pressure than brachial pressure while long-term administration of hydrochlorothiazide in patients with essential hypertension.
Methods: The retrograde analysis was conducted at three of the participating centers in the Felodipine...
22. 10. THE USEFULNESS OF ESTIMATED CAROTID SYSTOLIC BLOOD PRESSURE USING FORM PWV/ABI IN BLOOD PRESSURE LOWERING THERAPY
Hisayo Yasuda, Kei Kamide, Yoshio Iwashima, Takeshi Horio, Hidenori Nishida, Fumiki Yoshihara, Satoko Nakamura, Yuhei Kawano
Pages: 97 - 97
Background: Central systolic blood pressure (central-SBP) can be estimated noninvasively and antihypertensive drugs may exert different effects on central-SBP. We investigated the usefulness of carotid systolic blood pressure (carotid-SBP) estimated by form PWV/ABI in blood pressure lowering therapy.
Methods:...
23. 13. THE LONG-TERM EFFECT BETWEEN CO-ADMINISTRATION OF SIMVASTATIN AND EZETIMIBE AND ATORVASTATIN ON CENTRAL PULSE WAVE VELOCITY IN ADULTS WITH HYPERCHOLESTEROLEMIA
Young Soo Lee, Kee Sik Kim, Myung Jun Seong, Jung Hyun Kim, So Yeon Kim, Jin Bae Lee, Jae keun Ryu, Ji Yong Choi, GUg Sung Chang
Pages: 97 - 97
Background: The various statin might contribute to a change in arterial stiffness independent of the cholesterol-lowering effects of statin therapy. The aim of this study was to compare the short-term effect between co-administration of simvastatin and ezetimibe (vytorin) and atorvastatin (lipitor) on...
24. 14. USING CENTRAL BLOOD PRESSURE TO GUIDE THERAPY IN HYPERTENSION: BP GUIDE STUDY DESIGN AND INITIAL FINDINGS
James E. Sharman, Michael Stowasser, Deborah T. Gilroy, Thomas H. Marwick
Pages: 97 - 98
Background: Estimated central blood pressure (BP) predicts cardiovascular mortality independent of brachial BP, but whether central BP may be useful in clinical practice is unknown. This study aimed to test the value of central BP as a management tool for physicians treating patients with essential hypertension.
Methods:...
Conference Abstract
25. 12. THE EFFECT OF ORALLY SINGLE DOSE OF SLOW-RELEASE ISOSORBIDE-5-MONONITRATE ON CENTRAL BLOOD PRESSURE IN HEALTHY VOLUNTEERS
Shu-xian Du, Xiongjing Jiang, Ping Wang, Liu Yu-qing, Yi-shi Li
Pages: 97 - 97
Background: The cuff sphygmomanometer failed to show consistent alteration in brachial blood pressure with slow-release isosorbide-5-mononitrate(IS-5-MN), even though the drug proved very effective in relieving angina pectoris.Sofar, the effect of orally single dose of slow-release isosorbide-5-mononitrate...
26. 15. OPEN LABEL, RANDOMIZED, ACTIVE DRUG COMPARATIVE, PARALLEL GROUP, MULTI-CENTER, PHASE IV STUDY TO COMPARE THE EFFECT OF BENIDIPINE AND LOSARTAN ON ARTERIAL STIFFNESS AND CENTRAL BLOOD PRESSURE IN MILD TO MODERATE ESSENTIAL HYPERTENSIVE PATIENTS (BELASCO TRIAL)
Sang-Hyun Ihm, Shung Chull Chae, Do Sun Lim, Kee Sik Kim, Dong Ju Choi, Jong Won Ha, Dong Soo Kim, Kye Hun Kim, Myeong Chan Cho, Hui Kyung Jeon, Sang Hong Baek, The BELASCO trial investigators, Korea
Pages: 98 - 98
Objectives: The purpose of this study was to compare the effect of benidipine (calcium channel blocker) and losartan (angiotensin receptor blocker) on arterial stiffness and central blood pressure (BP) in mild to moderate essential hypertensives.
Methods and Results: This 24 weeks, multi-center, open...
27. 17. CAROTID INTIMA-MEDIA THICKNESS IN A LARGE COHORT STUDY AND REALLY NORMAL SUBJECTS
Woo-Baek Chung, Ho-Joong Youn, Yun-Seok Choi, Hee-Jung Hwang, Jae-Beom Lee, Jong-Won Chung, Chul-Soo Park, Yong-Seog Oh, Sang-Hong Baek, Wook-Sung Chung, Ki-Bae Seung, Jae-Hyung Kim
Pages: 98 - 98
Background: Carotid intima-media thickness (IMT) has been widely used as a surrogate of early atherosclerosis. However, the characteristics of patients in cohort-based studies of carotid IMT are very heterogeneous. We evaluated the carotid intima, media, and IMT in really normal (RN) subjects who had...
28. 16. IS IT POSSIBLE TO PREDICT CORONARY ARTERY STENOSIS BASED ON CAROTID ARTERY INTIMA MEDIA THICKNESS IN DIABETIC PATIENTS
Jong-Won Chung, Ho-Joong Youn, Yun-Seok Choi, Hee-Jung Hwang, Jae-Beom Lee, Woo-Baek Chung, Chul-Soo Park, Yong-Seog Oh, Wook-Sung Chung, Jae-Hyung Kim
Pages: 98 - 98
Background: Noninvasive measurement of carotid artery intima media thickness (IMT) has been widely used as a surrogate marker of coronary atherosclerosis. However, evidence for the clinical implications of increased carotid IMT in diabetic patients is not well established. The aim of this study was to...
Research Article
29. 18.ARTERIAL STIFFNESS IN GERIATRIC MEDICINE
Jeong Bae Park, Kee Sik Kim, Ho Joong Youn, Sang Hong Baek, Kyu Hyung Ryu, Shung Chull Chae, Jang Ho Bae, Jang Ho Bae, Chang Gyu Park, Moo Yong Rhee, Soo Yeun Choi, Dong Ju Choi, Sung Ha Park, Se Joong Rim, Dong Gu Shin, Gae Hoon Kim, Jong Chun Park, Won Ho Kim, Wang Seong Ryu, Kyung Ho Youn, Jin Won Jeong, Young Moo Ro, Young Dae Kim, Dong Soo Kim, Myeng Chan Cho, Byung Hee Oh, Nam Sik Chung, on behalf of Korean Vascular Research Working Group
Pages: 98 - 99
30. 22. BP VARIABILITY AS WELL AS MEAN BP FROM AMBULATORY BLOOD PRESSURE AND HOME BLOOD PRESSURE CORRELATES WELL WITH TARGET ORGAN DAMAGE IN UNTREATED HYPERTENSIVE PATIENTS
Ae-Young Her, Se-Joong Rim, Pil-Ki Min, Young Won Yoon, Bum-Kee Hong, Hyuck Moon Kwon
Pages: 99 - 99
Background: We sought to assess the relation of ambulatory blood pressure(ABP) measurement and home blood pressure(HBP) measurement with target organ damage using BP variability(BPV) as well as mean BP in untreated hypertensive patients.
Methods: Seventy-nine untreated patients with hypertension(men...
31. 21. THE ASSOCIATION OF BETWEEN CORONARY SPASM AND B-TYPE NATRIURETIC PEPTIDE AND PULSE WAVE VELOCITY
Jin Oh Na, Chang Gyu Park, Jae Hyoung Park, Cheol Ung Choi, Hong Euy Lim, Jin Won Kim, Eung Ju Kim, Seung-Woon Rha, Hong Seog Seo, Dong Joo Oh
Pages: 99 - 99
Background: Coronary spasm cause transient LV dysfunction and consequently may increase BNP by chance. However, the correlation between coronary spasm and BNP has not been verified. We investigated the association between coronary spasm and BNP and pulse wave velocity (PWV) in patients with preserved...
32. 20. CORRELATION OF AORTIC DISTENSIBILITY WITH CORONARY ATHEROSCLEROSIS IN ANGINA PATIENTS
Gwang-Sil Kim, Young-Sub Byun, Byoung Kwon Lee, Choong-Won Goh, Kun-Joo Rhee
Pages: 99 - 99
Background: Arterial stiffness is associated with an increased risk of cardiovascular disease. However, limited evidence exists on whether arterial stiffening correlates not only with cardiovascular events, but also with subclinical atherosclerotic lesions. This study aimed to provide information on...
Conference Abstract
33. 19. AORTIC DISTENSIBILITY IS MORE CLOSELY ASSOCIATED WITH CAROTID INTIMA MEDIA THICKNESS THAN AORTIC INTIMA-MEDIA THICKNESS IN THE PATIENTS WITH ISCHEMIC STROKE
Hyun Ju Yoon, Min Gu Lee, Jum Seok Ko, Kun Ho Park, Ju Han Kim, Younggeun Ahn, Myung Ho Jeong, Jung Gwan Cho, Jung Chaee Kang, Jong Chun Park
Pages: 99 - 99
Background: The aorta plays a central role for a modulator in whole cardiovascular system by its elasticity. If the elasticity was decreased, aortic distensibility was also decreased and stiffness index was elevated. In this study, we investigated the relationship between aortic distensibility calculated...
Commentary
34. HIV, pressure wave reflections, and arterial stiffness: It’s a matter of time
Giuseppe Schillaci, Giacomo Pucci, Giuseppe V.L. De Socio
Pages: 100 - 103
Research Article
35. Impact of human immunodeficiency virus infection on arterial stiffness and wave reflections in the early disease stages
Charalambos Vlachopoulos, Helen Sambatakou, Dimitris Tsiachris, Ilias Mariolis, Konstantinos Aznaouridis, Nikolaos Ioakeimidis, Athanasios J. Archimandritis, Christodoulos Stefanadis
Pages: 104 - 110
Background: Human immunodeficiency virus (HIV) infection is associated with subclinical inflammation and increased cardiovascular risk. Arterial stiffness and enhanced wave reflections are markers of cardiovascular disease and independent predictors of cardiovascular risk. The effect of HIV infection,...
Research Article
36. Vascular function is impaired early after the initiation of chronic cigarette smoking
Brian R. Weil, Shannon A. Byrne, Tracy Baynard, Jill A. Kanaley
Pages: 111 - 114
Background: The aim of this study was to assess resistance artery function in short-term chronic cigarette smokers and non-smoking control subjects.
Methods: Reactive hyperemia was assessed in 19 cigarette smokers (age 23±1 years) and 19 non-smokers (age 23±1 years).
Results: Cigarette smokers demonstrated...
Research Article
37. Inflammatory status, arterial stiffness and central hemodynamics in hypertensive patients with metabolic syndrome
Panagiota Pietri, Charalambos Vlachopoulos, Konstantinos Aznaouridis, Katerina Baou, Panagiotis Xaplanteris, Ioanna Dima, Gregory Vyssoulis, Christodoulos Stefanadis
Pages: 115 - 121
Introduction: Inflammatory state is activated in metabolic syndrome and may explain part of the adverse prognosis of this entity. Arterial stiffness, central blood pressures and wave reflections are independent predictors of cardiovascular risk. This study investigates the relation between low-grade...
Short Communication
38. Anterior chamber bevacizumab for rubeotic glaucoma secondary to retinal artery occlusion☆
Rajan Bhojwani, Simon P. Kelly
Pages: 122 - 123
A 73-year-old Caucasian female, presented with sudden loss of vision in the right eye due to a central retinal artery occlusion (CRAO). The patient presented acutely 10-weeks later with a painful right eye due to rubeosis; intraocular pressure (IOP) was 67mmHg. A single anterior chamber injection of...