12. THE EFFECT OF ORALLY SINGLE DOSE OF SLOW-RELEASE ISOSORBIDE-5-MONONITRATE ON CENTRAL BLOOD PRESSURE IN HEALTHY VOLUNTEERS

DOI

10.1016/j.artres.2009.06.024How to use a DOI?

Abstract

Background: The cuff sphygmomanometer failed to show consistent alteration in brachial blood pressure with slow-release isosorbide-5-mononitrate(IS-5-MN), even though the drug proved very effective in relieving angina pectoris.Sofar, the effect of orally single dose of slow-release isosorbide-5-mononitrate on central blood pressure is not known.

Methods: Using self-control study before and after treatment in a total of 22 healthy volunteers, the effects of slow-release IS-5-MN 60mg in single dose form were assessed over a tweenty four hour period through analysis of the radial pulse waveform, calibrated against conventional cuff sphygmomanometry. Ascending aortic pressure waveforms were generated from the radial waves, using a validated generalised transfer function. The concentration of 5-ISMN were measured by HPLC-MS.

Results: After taken the drug, the concentration of 5-ISMN was rapidly increased to peak at 4h, then linearly decreased to 187.6 ng/ml at 24h. There was no consistent change in heart rate or brachial pressures except for a decrease in systolic pressures and a increase in heart rate (p<0.01) at 2-6hour. In contrast, there were substantial and significant decreases in aortic systolic pressures, augmented pressures, augmentation index and ejection duration (p<0.001) at 0.5h-16h.

Conclusion: Pulse waveform analysis exposes concentration dependent effects of 5-ISMN on the aortic waveform, suggesting muscular conduit arterial dilatation with reduced wave reflection and venous dilatation with reduced ejection duration at the low and intermediate concentration, arteriolar dilatation and decreased peripheral resistance at the high concentration.

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TY  - JOUR
AU  - Shu-xian Du
AU  - Xiongjing Jiang
AU  - Ping Wang
AU  - Liu Yu-qing
AU  - Yi-shi Li
PY  - 2009
DA  - 2009/10/31
TI  - 12. THE EFFECT OF ORALLY SINGLE DOSE OF SLOW-RELEASE ISOSORBIDE-5-MONONITRATE ON CENTRAL BLOOD PRESSURE IN HEALTHY VOLUNTEERS
JO  - Artery Research
SP  - 97
EP  - 97
VL  - 3
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.06.024
DO  - 10.1016/j.artres.2009.06.024
ID  - Du2009
ER  -