11. THE EFFECT OF LONG-TERM ADMINISTRATION OF HYDROCHLOROTHIAZIDE ON CENTRAL BLOOD PRESSURE

DOI

10.1016/j.artres.2009.06.023How to use a DOI?

Abstract

Background: It’s unknown wheather there is much benefit on central aortic pressure than brachial pressure while long-term administration of hydrochlorothiazide in patients with essential hypertension.

Methods: The retrograde analysis was conducted at three of the participating centers in the Felodipine Event Reduction (FEVER) study. 76 of 129 patients in placebo group, who kept hydrochlorothiazide monotherapy over 36 months period, and took pulse wave recording at randomization, 12 month, 24 month and 36 month, were included into the final analysis. Radial artery pressure waveforms were measured with applanation tonometry, and convolved into the ascending aortic pressure waveforms, using the FDA-approved SphygmoCor system. The analysed parameters in aortic pressure waveform included first peak pressure, secondary peak pressure, diastolic pressure, pulse pressure, augmentation and augmentation index.

Results: In comparison with baseline, there were substantial falls (P<0.001) in brachial SP/DP and in central aortic SP/DP with no difference, slight falls (P<0.05) in aortic augmentation, and no significant falls (P>0.05) in augmentation index and heart rate.

Conclusion: Long-term administration of hydrochlorothiazide resulted in the similar reduction of both brachial pressure and central aortic pressure without the change of augmentation index, which could exclude definite benefit on central aortic pressure than brachial pressure.

Open Access

This is an open access article distributed under the CC BY-NC license.

TY  - JOUR
AU  - Yang Qian
AU  - Jiang Xiongjing
AU  - Zhang Yuqing
AU  - Liu Lisheng
PY  - 2009
DA  - 2009/10/31
TI  - 11. THE EFFECT OF LONG-TERM ADMINISTRATION OF HYDROCHLOROTHIAZIDE ON CENTRAL BLOOD PRESSURE
JO  - Artery Research
SP  - 97
EP  - 97
VL  - 3
IS  - 3
SN  - 1876-4401
UR  - https://doi.org/10.1016/j.artres.2009.06.023
DO  - 10.1016/j.artres.2009.06.023
ID  - Qian2009
ER  -