Correlation between Glutathione Levels and Severity Symptoms among Bataknese Male patients with Schizophrenia

DOI

10.2991/978-94-6463-310-8_28How to use a DOI?

Keywords

Schizophrenia; Oxidative Stress; Glutathione; GSH; Positive-Negative Symptoms; Positive and Negative Syndrome Scale (PANSS)

Abstract

Background: Oxidative stress has been implicated as a part of the pathophysiological mechanisms of Schizophrenia. Oxidative stress occurs due to the imbalance of antioxidants and oxidants. Glutathione is one of the primary antioxidants that contribute to the oxidative-stress-preventable mechanism. The correlation between oxidative stress, glutathione deficiency, and schizophrenic pathophysiology has been reported in previous clinical studies. The reduction of glutathione, particularly in schizophrenic symptomatology (especially in negative and positive symptoms), has been characterized.

Methods: A cross-sectional study recruited 48 Bataknese males with Schizophrenia who have been administered atypical antipsychotic medications for at least a year. The glutathione levels were measured by the ELISA Method to calculate the quantitative results of GSH concentration within the blood plasm in vitro. The severity of symptoms was characterized via the Positive and Negative Syndrome Scale (PANSS).

Results: Our study found a significant correlation between glutathione levels and the severity of symptoms of Schizophrenia (p<0.05). The Pearson correlation value was -0.587, a negative value with medium correlation strength.

Conclusion: Our findings support the fact that oxidative stress is one of the pathophysiological mechanisms of Schizophrenia. This study also showed that a low glutathione level is associated with the severity of symptoms of Bataknese males with Schizophrenia.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Shela Gustirani
AU  - Elmeida Effendy
AU  - Vita Camellia
PY  - 2023
DA  - 2023/12/18
TI  - Correlation between Glutathione Levels and Severity Symptoms among Bataknese Male patients with Schizophrenia
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 181
EP  - 186
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_28
DO  - 10.2991/978-94-6463-310-8_28
ID  - Gustirani2023
ER  -