Physical Stability Test, Penetration Efficiency and Absorption of Leaf Ethosome Extracts Tekelan (Chromolaena odorata L.)
- DOI
- 10.2991/978-94-6463-310-8_29How to use a DOI?
- Keywords
- Etosome; Physical Stability; Flavonoids; Adsorption Efficiency; Penetration
- Abstract
Ethosomes are innovative lipid-based vesicular systems containing relatively high concentrations of phospholipids, ethanol, and relatively high air. The presence of phospholipids and ethanol can enhance the permeation and penetration of the drug more profoundly into the skin layers. This study aimed to test the physical stability, penetration and adsorption efficiency of autosomal ethanol extract of tekelan leaves. Methods. The method used in this study was the physical stability test of ethosomal preparations with varying concentrations of F1 (autosomal quote without extract), F2 (0.5 g autosomal extract in 10 mL ethanol), F3 (2 g autosomal extract in 20 mL ethanol) and F4 (1.5 g autosomal extract in 30 mL ethanol). Test Physical stability test includes pH, viscosity, storage stability at room temperature, low temperature, high temperature and cycle test. High temperature and cycle test. In addition, the total flavonoid content in the extract was replaced, expressed as mgEQ/g ethosome and entrapment test and penetration efficiency were performed. The results obtained in this study showed that all formulas met the skin pH requirement (4.5-6.5) after 12 weeks of storage and were stable during 12 weeks of storage at room temperature. Stable during 12 weeks of storage at room temperature, low and high temperatures. F4 has the lowest pH after 12 weeks of storage (4.10 ± 0.00) with viscosity (3519.33 ± 55.72 cP). Per cent binding efficiency in F4 (68.44%) and total quercetin compound collection (11210.204 ± 815.049 mcg/cm2), per cent collection of quercetin compounds (38.824 ± 0.446%) and flux of inhibition of quercetin compound (23.014 ± 1.732 mcg.cm-2.hour-1 ). This study concluded that the ethanol preparation (1.5 g extract in 30 mL) was physically stable during storage at various temperatures with the best entrapment and penetration efficiency.
- Copyright
- © 2023 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Sofia Rahmi AU - Julia Reveny AU - Anayanti Arianto AU - Panal Sitorus PY - 2023 DA - 2023/12/18 TI - Physical Stability Test, Penetration Efficiency and Absorption of Leaf Ethosome Extracts Tekelan (Chromolaena odorata L.) BT - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023) PB - Atlantis Press SP - 187 EP - 197 SN - 2468-5739 UR - https://doi.org/10.2991/978-94-6463-310-8_29 DO - 10.2991/978-94-6463-310-8_29 ID - Rahmi2023 ER -