Hypercrosslinked Polymers (HCPs) have received considerable attention in the field of catalysis, adsorption, separation, biomedical engineering, and energy storage/conversion, because of their permanent microporous structures and high surface areas. Up to now, various “bottom-up” and “top-down” methods...

Remdesivir is a broad spectrum antiviral agent meant to inhibit viral RNA polymerases against members of several virus families, including filoviruses. Although reported for significant clinical improvements in COVID-19, a detailed observation of the connection with the drawbacks of remdesivir therapy...

Cancer is a devastating disease that can be challenging to treat. Fortunately, immune cells called T-cells can be activated for tumour destruction. Signal 1 of T-cell activation is provided by antigen presentation through the (T-cell receptor/major histocompatibility complex) interaction. Signal 2 of...

Traditional cancer therapy faces the main fail due to the effect of drug burst release, hindering the long-term therapeutic efficacy. SiO2 nano systems possess high-capacity and pH-controlled release for anti-cancer drug, improving the curative efficacy in cancer treatment. Thus, we designed a novel...

A series of Polyaniline (PANI) nanoparticles doped with citric acid were synthesized by situ polymerization. It is interesting that uniform nanofibers with the diameter of 50 nm formed under a proper mass ratio (aniline:citric acid) of 5:4, which forms 3D conductive networks. XRD patterns show the nanofibers...

In this work, Cu–4.9% Al alloy with little Si (the weight percentage is 1.3%) and little Mn (the weight percentage is 0.8%) was deposited by wire arc additive manufacturing. Microstructure and properties of the deposited alloy was investigated. Microstructural characterization was done using optical...

This paper presents the synthesis of Barium Oxide Nanoparticles (BaO-NPs) on a large-scale by a simple and cost-effective co-precipitation method. The as-synthesized BaO-NPs were characterized in aspects of their structural, morphological, compositional, and optical properties. X-ray diffraction was...

Janus and core–shell nanostructures are the most fundamental structural characteristics for comprising all types of multiple-chamber structures. The facile preparation of Janus structure is one of the most difficult challenges in the field of nanofabrication, whose production can pave a broad way for...

The impairment in the Tympanic Membrane (TM) and the External Auditory Canal (EAC) results in otitis media, tympanos-clerosis, and perforations. The resulting reverberation of these pathologies is the loss of hearing, which eventually requires surgical treatment. The gold standard for the surgical procedures,...

There is a growing interest in the use of melatonin in preventing radiation-induced mucositis with potential beneficial effects including prevention of mucosal damage, the emergence of ulcers and the loss of proliferative progenitor stem cells caused by radiation. Local drug delivery to the oral cavity...

Dual-stage release, consisting of a first fast release for eliminating the uncomfortable symptoms and a later sustained release for a long time period for reducing the administration times, is highly welcomed by the patients. In the present investigation, a new type of core-shell Electrosprayed Nanoparticles...

Electrospinning is a potent “top-down” nanofabrication method and has been explored by many researchers in recent decades because it is an efficient, versatile, simple, and low-cost route to prepare nanofibers. Nanofiber membranes generated by electrospinning have been used in various fields including...