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Volume 1, Issue 1-2, September 2020, Pages 14 - 21

Dual-stage Release of Ketoprofen from Electrosprayed Core–Shell Hybrid Polyvinyl Pyrrolidone/Ethyl Cellulose Nanoparticles

Authors
Pu Wang1, 2, Meng-long Wang1, Xi Wan1, Honglei Zhou1, Heng Zhang1, Deng-Guang Yu1, *
1School of Material Science and Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China
2School of Advanced Vocational Education, Shanghai University of Engineering Science, Shanghai 200437, China
*Corresponding author. Email: ydg017@usst.edu.cn
Corresponding Author
Deng-Guang Yu
Received 20 April 2020, Accepted 20 July 2020, Available Online 31 August 2020.
DOI
10.2991/mathi.k.200825.001How to use a DOI?
Keywords
Electrospraying; core–shell nanoparticles; dual-stage release; polymeric nanohybrids
Abstract

Dual-stage release, consisting of a first fast release for eliminating the uncomfortable symptoms and a later sustained release for a long time period for reducing the administration times, is highly welcomed by the patients. In the present investigation, a new type of core-shell Electrosprayed Nanoparticles (ENPs) were developed for providing a dual-stage controlled release profile of Ketoprofen (KET). A coaxial electrospraying process was explored to prepare the core–shell particles in a directly and straightforward manner. The resultant ENPs were tested in terms of morphology and inner structure, physical state and compatibility between KET and the core matrix of ethyl cellulose, between KET and the shell matrix of polyvinyl pyrrolidone, and the dual-stage controlled release performances. The results from scanning electron microscopy and transmission electron microscope observations demonstrated that the core–shell polymeric nanohybrids had a round morphology with an average diameter of 570 ± 120 nm, and a clear core–shell structure with an estimated shell thickness of 70 nm. KET presented in the ENPs in an amorphous state thanks to the fine compatibility of the hybrid components, as verified by X-ray diffraction and fourier transform infrared spectroscopy (FTIR) tests. In vitro dissolution tests exhibited that the ENPs were able to provide a designed dual-stage controlled release profile with an amount of 45.1 ± 4.5% for the first stage.

Copyright
© 2020 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
Materials Highlights
Volume-Issue
1 - 1-2
Pages
14 - 21
Publication Date
2020/08/31
ISSN (Online)
2666-4933
DOI
10.2991/mathi.k.200825.001How to use a DOI?
Copyright
© 2020 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Pu Wang
AU  - Meng-long Wang
AU  - Xi Wan
AU  - Honglei Zhou
AU  - Heng Zhang
AU  - Deng-Guang Yu
PY  - 2020
DA  - 2020/08/31
TI  - Dual-stage Release of Ketoprofen from 	Electrosprayed Core–Shell Hybrid Polyvinyl Pyrrolidone/Ethyl Cellulose Nanoparticles
JO  - Materials Highlights
SP  - 14
EP  - 21
VL  - 1
IS  - 1-2
SN  - 2666-4933
UR  - https://doi.org/10.2991/mathi.k.200825.001
DO  - 10.2991/mathi.k.200825.001
ID  - Wang2020
ER  -