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Volume 2, Issue 3, June 2021, Pages 52 - 57

PVP-Induced Synthesis of Silica Nanoparticles with Tailored Size for pH-Controlled Drug Release

Authors
Wei Yang1, Zheng Yang2, *
1Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China
2School of Chemistry and Materials Engineering, Fuyang Normal University, Fuyang 236037, P. R. China
*Corresponding author. Email: zhengyang@fynu.edu.cn
Corresponding Author
Zheng Yang
Received 8 December 2020, Accepted 9 April 2021, Available Online 21 April 2021.
DOI
10.2991/mathi.k.210414.001How to use a DOI?
Keywords
PVP-induced synthesis; SiO2 nanoparticles; drug delivery; pH-controlled drug release; cancer treatment
Abstract

Traditional cancer therapy faces the main fail due to the effect of drug burst release, hindering the long-term therapeutic efficacy. SiO2 nano systems possess high-capacity and pH-controlled release for anti-cancer drug, improving the curative efficacy in cancer treatment. Thus, we designed a novel method to construct Silica Nanoparticles (SiO2 NPs) with diameters of ca. 150 nm by adding different amounts of PVP. The maximum drug-loading of the synthesized SiO2 NPs is about 30 μg·mg−1, exhibiting excellent pH-responsive drug releasing ability in the simulated physiological environment. Meanwhile, the prepared SiO2 NPs also harbor well biocompatibility, which are suitable for potential cancer therapy in clinic.

Copyright
© 2021 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
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Journal
Materials Highlights
Volume-Issue
2 - 3
Pages
52 - 57
Publication Date
2021/04/21
ISSN (Online)
2666-4933
DOI
10.2991/mathi.k.210414.001How to use a DOI?
Copyright
© 2021 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Wei Yang
AU  - Zheng Yang
PY  - 2021
DA  - 2021/04/21
TI  - PVP-Induced Synthesis of Silica Nanoparticles with Tailored Size for pH-Controlled Drug Release
JO  - Materials Highlights
SP  - 52
EP  - 57
VL  - 2
IS  - 3
SN  - 2666-4933
UR  - https://doi.org/10.2991/mathi.k.210414.001
DO  - 10.2991/mathi.k.210414.001
ID  - Yang2021
ER  -