Development of a Derivative of 1,4-Dihydropyridine Gels Using Solid Dispersion Technique

DOI

10.2991/isils-19.2019.43How to use a DOI?

Keywords

nifedipine, solid dispersions, gel, polyethylene glycol

Abstract

A method has been developed for obtaining samples of a derivative of 1,4-dihydropyridine-nifedipine gels using the solid dispersion technique. A quality assessment of the obtained soft dosage forms has been performed. The effectiveness of the proposed technique for obtaining nifedipine gels has been proved, which makes it possible to increase the pharmaceutical availability of the poorly water soluble investigational substance, providing better release by increasing its solubility and dissolution rate.

Copyright

© 2019, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ivan Krasnyuk (Jr.)
AU  - Viktoriya Grikh
AU  - Ivan Krasnyuk
AU  - Anastasiya Belyatskaya
AU  - Olga Stepanova
AU  - Vladimir Beketov
AU  - Galina Varenykh
PY  - 2019/11
DA  - 2019/11
TI  - Development of a Derivative of 1,4-Dihydropyridine Gels Using Solid Dispersion Technique
BT  - Proceedings of the 1st International Symposium Innovations in Life Sciences (ISILS 2019)
PB  - Atlantis Press
SP  - 281
EP  - 284
SN  - 2468-5747
UR  - https://doi.org/10.2991/isils-19.2019.43
DO  - 10.2991/isils-19.2019.43
ID  - Krasnyuk(Jr.)2019/11
ER  -