Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

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Correlation Between Lipid Profiles with Pancreatic β-Cell Function in Patients with Type 2 Diabetes Mellitus

Authors
Dwi Sarbini, Emy Huriyati, Ahmad Hamim Sadewa, Mae Sri Hartati Wahyuningsih
Corresponding Author
Dwi Sarbini
Available Online 22 February 2020.
DOI
10.2991/ahsr.k.200215.057How to use a DOI?
Keywords
HOMA-β, lipid profiles, type 2 diabetes
Abstract

Type 2 Diabetes Mellitus (T2DM) is characterized by 2 times higher blood glucose and lipid profile than non-diabetic people. Several studies indicated that pancreatic β cell dysfunction due to dyslipidemia is an independent risk factor T2DM. Dyslipidemia on T2DM can lead pancreatic β cell dysfunction. Objective: This study aimed to determine the correlation between lipid profiles (triglyceride, total cholesterol, LDL, and HDL) with pancreatic β cell function (HOMA-β) in patients with T2DM. Methods: This research method is a cross-sectional study of 50 patients with T2DM at Community Health Center (45-65 years old). Lipid profiles level were analized by glycerol-3-phosphate-oxidase (GPO) PAP method (Genius) and insulin level was analized by using ELISA. β cell function is measured using HOMA-β. Pearson Correlation test was used to assess the correlation between lipid profiles with HOMA-β (p value <0.05) Results: This study showed no significant relationship between triglyceride and HOMA-β (p= 0,430), total cholesterol with HOMA-β (p=0,717), LDL with HOMA-β (p=0,633), HDL with HOMA-β (p=0,754). There is no significant relationship between lipid profiles (triglyceride, total cholesterol, LDL, and HDL) and β cell function. For further research, it is recommended to examine other factors such as food intake by taking into account the drugs consumed.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
Series
Advances in Health Sciences Research
Publication Date
22 February 2020
ISBN
978-94-6252-911-3
ISSN
2468-5739
DOI
10.2991/ahsr.k.200215.057How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Dwi Sarbini
AU  - Emy Huriyati
AU  - Ahmad Hamim Sadewa
AU  - Mae Sri Hartati Wahyuningsih
PY  - 2020
DA  - 2020/02/22
TI  - Correlation Between Lipid Profiles with Pancreatic β-Cell Function in Patients with Type 2 Diabetes Mellitus
BT  - Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
PB  - Atlantis Press
SP  - 298
EP  - 304
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200215.057
DO  - 10.2991/ahsr.k.200215.057
ID  - Sarbini2020
ER  -