Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

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Resistin Protein Analysis Using Receiver Operating Characteristics Curve in Predicting the Occurrence of Type 2 Diabetes Mellitus in Respondents of Cohort Study of Risk Factors for Noncommunicable Diseases in Bogor

Authors
Uly Alfi Nikmah, Asri Werdhasari, Frans Dany, Tati Febrianti, Dwi Febriyana, Ni Ketut Susilarini
Corresponding Author
Uly Alfi Nikmah
Available Online 22 February 2020.
DOI
10.2991/ahsr.k.200215.105How to use a DOI?
Keywords
diabetes mellitus, ROC, resistin
Abstract

Resistin is a hormone that involved in obesity and type 2 diabetes mellitus. High resistin level in pre-DM respondents with obesity will cause insulin resistance. ROC analysis is used as an initial screening to predict chronic diseases precisely and accurately to look for high specificity values. The method was carried out in cross sectional method by examining protein in 744 respondents in the cohort study. Blood plasma was examined with an ELISA kit and analyzed with a Receiver Operating Characteristic curve (ROC Curve). The cutoff point results of pre-DM Resistin levels of respondents compared to normal respondents were 5.9 ng / ml with AUC (Area Under Curve) 0.68 (0.63-0.73), (P <0.001), sensitivity 74.8% and specificity 62.4%. While the Area Under Curve in the combined protein (resistin, insulin, adiponectin and c-peptide) increased to 0.86 (0.82-0.9) (P <0.001), sensitivity 77.7% and specificity 78.8%. Conclusion = resistin can be used as a biomarker in Prediabetes respondents to predict becoming diabetes.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
Series
Advances in Health Sciences Research
Publication Date
22 February 2020
ISBN
978-94-6252-911-3
ISSN
2468-5739
DOI
10.2991/ahsr.k.200215.105How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Uly Alfi Nikmah
AU  - Asri Werdhasari
AU  - Frans Dany
AU  - Tati Febrianti
AU  - Dwi Febriyana
AU  - Ni Ketut Susilarini
PY  - 2020
DA  - 2020/02/22
TI  - Resistin Protein Analysis Using Receiver Operating Characteristics Curve in Predicting the Occurrence of Type 2 Diabetes Mellitus in Respondents of Cohort Study of Risk Factors for Noncommunicable Diseases in Bogor
BT  - Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
PB  - Atlantis Press
SP  - 545
EP  - 548
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200215.105
DO  - 10.2991/ahsr.k.200215.105
ID  - Nikmah2020
ER  -