Proceedings of the 4th International Symposium on Health Research (ISHR 2019)

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Polymorphism UCP2 Gene in Predicting the Occurrence of Type 2 Diabetes Mellitus in Respondents Cohort Study of Risk Factors for Non-communicable Diseases in Bogor, West Java, Indonesia

Authors
Asri Werdhasari, Uly Alfi Nikmah, Frans Dany, Holy Arif Wibowo, Ratih Rinendyaputri
Corresponding Author
Asri Werdhasari
Available Online 22 February 2020.
DOI
10.2991/ahsr.k.200215.108How to use a DOI?
Keywords
SNP, UCP2, rs660339, diabetes, prediabetes
Abstract

Diabetes mellitus type 2 (DM) is a risk factor for other non-communicable diseases and is a problem, along with the increasing prevalence in Indonesia. One of the proteins involved in the occurrence of diabetes is UCP2, which is produced by the UCP2 gene. So that the polymorphism in this gene is likely to affect the incidence of diabetes. This study uses a cross-sectional method in a population study cohort of risk factors for non-communicable diseases (RF-NCD) conducted in the city of Bogor, West Java, Indonesia. This analysis aims to determine the relationship of UCP2 gene polymorphisms rs660339 on the incidence of DM and pre-DM. SNP examination was performed using the Taqman method and analyzed by Taqman Genotyper. Hardy-Weinberg Equilibrium (HWE) analysis and odds ratios (OR) using online software from www.oege.org. Taqman Genotyper analysis results show the minor alleles in the UCP2 rs660339 gene are A and the lowest frequency is the A/A genotype. The calculation of OR shows that the G/G genotype in the UCP2 rs660339 gene has the potential to become pre-DM.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
Series
Advances in Health Sciences Research
Publication Date
22 February 2020
ISBN
978-94-6252-911-3
ISSN
2468-5739
DOI
10.2991/ahsr.k.200215.108How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Asri Werdhasari
AU  - Uly Alfi Nikmah
AU  - Frans Dany
AU  - Holy Arif Wibowo
AU  - Ratih Rinendyaputri
PY  - 2020
DA  - 2020/02/22
TI  - Polymorphism UCP2 Gene in Predicting the Occurrence of Type 2 Diabetes Mellitus in Respondents Cohort Study of Risk Factors for Non-communicable Diseases in Bogor, West Java, Indonesia
BT  - Proceedings of the 4th International Symposium on Health Research (ISHR 2019)
PB  - Atlantis Press
SP  - 559
EP  - 562
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200215.108
DO  - 10.2991/ahsr.k.200215.108
ID  - Werdhasari2020
ER  -