Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)

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The Role of TGF Beta 1 and PDGF BB in Wound Healing of the Palate

Authors
Olivia Avriyanti Hanafiah, Reevanash Poravi, Devina Angga, Trimurni Abidin, Syafrudin Ilyas, Marline Nainggolan, Endang Syamsudin
Corresponding Author
Olivia Avriyanti Hanafiah
Available Online February 2018.
DOI
10.2991/idcsu-17.2018.57How to use a DOI?
Keywords
Transforming Growth Factor Beta-1 (TGF-1), Platelet-Derived Growth Factor-BB (PDGF-BB), wound healing, palate
Abstract

Oral wound healing is a process that consists of three highly integrated and overlapping phases inflammation, proliferation and tissue remodelling. These phases involve the interaction between many cells and growth factors that work together from the beginning of an injury to complete tissue formation either through regeneration of tissue or by scar formation. At the point of injury, circulating platelets are capable of secreting growth factors needed during the wound healing phases. Growth factors such as transforming growth factor beta-1(TGF-1) and platelet-derived growth factor-BB (PDGF-BB) involved in oral wound healing stimulates epithelial proliferation and angiogenesis within the injured tissue.Proliferation of epithelial cells in wound healing and formation of new blood vessels (angiogenesis) plays a significant role in healing of keratinized mucosa such as the palate and gingiva. Therefore, TGF- and PDGF, being one of the major growth factors in oral wound healing is found to play a pivotal role in tissue healing of the palatal mucosa after an injury.

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
Series
Advances in Health Sciences Research
Publication Date
February 2018
ISBN
978-94-6252-474-3
ISSN
2468-5739
DOI
10.2991/idcsu-17.2018.57How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

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TY  - CONF
AU  - Olivia Avriyanti Hanafiah
AU  - Reevanash Poravi
AU  - Devina Angga
AU  - Trimurni Abidin
AU  - Syafrudin Ilyas
AU  - Marline Nainggolan
AU  - Endang Syamsudin
PY  - 2018/02
DA  - 2018/02
TI  - The Role of TGF Beta 1 and PDGF BB in Wound Healing of the Palate
BT  - Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
PB  - Atlantis Press
SP  - 219
EP  - 225
SN  - 2468-5739
UR  - https://doi.org/10.2991/idcsu-17.2018.57
DO  - 10.2991/idcsu-17.2018.57
ID  - AvriyantiHanafiah2018/02
ER  -