Chlorpromazine-Induced Anemia in Schizophrenia Patient: A Case-Report

DOI

10.2991/978-94-6463-070-1_13How to use a DOI?

Keywords

Chlorpromazine; Drug-induced anemia; Typical antipsychotic; Side effect

Abstract

Introduction: Chlorpromazine is a typical class of antipsychotics used in Indonesia for psychotic diseases. At the Ghrasia mental hospital in Yogyakarta, chlorpromazine is given to patients with manic-type schizophrenia. The side effects of chlorpromazine include extrapyramidal, agranulocytosis, leukocytosis, and hemolytic anemia. Anemia is one of the rare side effects of chlorpromazine. Case: We report a case of a 57-year-old male who was referred to Ghrasia Hospital for a second hospitalization on 19 December 2019. At the first hospitalization, the patient was diagnosed with undifferentiated schizophrenia. The patient prescribes risperidone, clozapine, and trihexyphenidyl for therapy. The patient was diagnosed with manic-type schizoaffective disorder in the second hospitalization. Currently, prescribed therapies are risperidone, chlorpromazine, trihexyphenidyl, and diazepam. The patient then developed anemia the day after with Hb of 11.5g/dL (14–18g/dL). The next day patient was recommended for a hematocrit examination. The result was hematocrit of 37% (38,8–50%). The physicians then stopped the administration of chlorpromazine on day two. The patient was treated with tablets containing iron fumarate 300 mg, magnesium sulfate 0.4 mg, copper sulfate 0.4 mg, vitamin C 100 mg, folic acid 2 mg, vitamin B12 15 mcg, and intrinsic factor 25 mg. Chlorpromazine was readministered on 30 December 2019 (day 12th) with an initial dose of 100 mg and a subsequent 25 mg. The physicians prescribe an iron-containing multivitamin tablet. From the analysis results using the Naranjo algorithm, a score of 7 was obtained, which means that chlorpromazine was probable to cause anemia. Conclusion: In this case, chlorpromazine probably caused anemia. The patient was still given chlorpromazine ten days later, so monitoring the complete blood count was necessary.

Copyright

© 2022 The Author(s)

Open Access

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TY  - CONF
AU  - Bangunawati Rahajeng
AU  - Astrit Ikafitriani
AU  - Nurul Maziyyah
PY  - 2022
DA  - 2022/12/26
TI  - Chlorpromazine-Induced Anemia in Schizophrenia Patient: A Case-Report
BT  - Proceedings of the International Conference on Sustainable Innovation on Health Sciences and Nursing (ICOSI-HSN 2022)
PB  - Atlantis Press
SP  - 90
EP  - 95
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-070-1_13
DO  - 10.2991/978-94-6463-070-1_13
ID  - Rahajeng2022
ER  -