Differences in Selenium Levels between People with Schizophrenia and Control Groups

DOI

10.2991/978-94-6463-310-8_20How to use a DOI?

Keywords

selenium levels; PANSS; people with schizophrenia; control

Abstract

Background

Cognitive, emotional, and behavioural symptoms of schizophrenia affect various areas of mental function. Schizophrenia is a mental condition. The lifetime prevalence of this condition ranges from 0.3% to 0.7%, with rates fluctuating depending on migration, urbanization, and socioeconomic position. The oxidative stress theory, which contends that it contributes to brain damage, is one of many hypotheses addressing the pathophysiology of schizophrenia. Through selenoproteins, Selenium, an essential element for the body, participates in the defence against oxidative stress. According to earlier research, selenium supplementation can help persons with schizophrenia (PWS) have better memory. However, it was discovered that PWS had lower levels of Selenium than the control groups. Cognitive impairment is an essential aspect of the clinical course of schizophrenia. Therefore, this study aims to examine the correlation between selenium levels and schizophrenia in Indonesia.

Method

This comparative analytical observational study with a cross-sectional approach assessed differences in selenium levels between PWS and control groups. Selenium levels were evaluated using the Inductively Coupled Plasma Mass Spectrometry (ICP-MS) technique on the sample, comprising 100 people with schizophrenia and 100 controls. The Mann-Whitney U and Chi-Square tests were used for data analysis in the Statistical Package for the Social Sciences (SPSS).

Results

The demographic data showed no significant differences in gender (p=0.887) and age (p=0.509). The PANSS score and selenium levels did not significantly correlate with one another (r=0.188, p=0.061). However, selenium levels between the PWS and control groups differed significantly (z= -2.324, p=0.020).

Conclusion

The findings offer insightful early data on the possible involvement of Selenium in PWS development. Additional research is required to validate these results and deepen our understanding of the relationship between Selenium and PWS.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Nabilah Aulia Hasanuddin
AU  - Elmeida Effendy
AU  - Vita Camellia
PY  - 2023
DA  - 2023/12/18
TI  - Differences in Selenium Levels between People with Schizophrenia and Control Groups
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 135
EP  - 140
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_20
DO  - 10.2991/978-94-6463-310-8_20
ID  - Hasanuddin2023
ER  -