BDNF Val66Met Polymorphism and Incidence of Childhood Trauma in Bataknese Schizophrenia Patient

DOI

10.2991/978-94-6463-310-8_8How to use a DOI?

Keywords

BDNF Val66Met; polymorphism; schizophrenia; childhood trauma; Bataknese

Abstract

Background

Schizophrenia is a severe brain disease with severe and persistent psychotic manifestations accompanied by dysfunction of cognitive and psychosocial variables. Numerous studies indicate that a mix of genetic and environmental variables may be responsible for the aetiology of schizophrenia. BDNF Val66Met, functional polymorphism is a candidate genetics, and childhood trauma is an environmental factor thought to be associated with the incidence of schizophrenia. This study aimed to analyze the relationship between BDNF Val66Met polymorphism and childhood trauma between Bataknese people with schizophrenia (SP) and Bataknese healthy people.

Method

This is a multivariate comparative analytical study with a case-control design. Blood samples were taken from a total of 200 subjects (n = 100) for each Schizophrenia patient (SP) and control group (CO), then BDNF Val66Met allele and genotype identification was carried out using the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) technique. The WHO-ACE IQ is used as an instrument for childhood trauma.

Results

There was no significant difference between the BDNF Val66Met polymorphism allele in SP and healthy controls with a value of p = 0.107, OR 1.413 IK95% (0.951-2.099). There was no significant difference between the BDNF Val66Met polymorphism genotype in SP and healthy controls of Met/Met vs Val/Val genotypes with p values of 0.063, OR 0.486 (0.227-1.039)CI95%, Val/Met vs Val/Val with p =0.291, OR 1.414 (0.744-3.689)CI95%. There is a significant difference between the incidence of childhood in the CM and FD domains with p<0.001, in the CM domain with an OR 5.096 (2.473-10.5)CI95% and in the FD domain with OR 10.778 (3.135-37.054)CI95%, in the VIO domain, there is no significant difference of p=0.056 with OR 4.846 (1.020-23.028) CI95%. There was no significant difference between Val66Met's BDNF polymorphism and the incidence of childhood trauma, domains CM, FD and VIO, with a p>0.05 value.

Conclusions

There was no difference between allele and genotype polymorphism BDNF Val66Met between SP and healthy controls. A significant difference between CM and FD, domain childhood trauma, exists between SP and healthy controls. There was no association between BDNF Val66Met polymorphism and childhood trauma in SP and control.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Diana ILC
AU  - Mustafa M. Amin
AU  - M. Surya Husada
AU  - M. Hanip Fahri
AU  - Reny Barus
AU  - Catherine
PY  - 2023
DA  - 2023/12/18
TI  - BDNF Val66Met Polymorphism and Incidence of Childhood Trauma in Bataknese Schizophrenia Patient
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 58
EP  - 67
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_8
DO  - 10.2991/978-94-6463-310-8_8
ID  - ILC2023
ER  -