Differences in Interleukin-4-590 C/T Variants Between Batak People with Schizophrenia and Healthy Control

DOI

10.2991/978-94-6463-310-8_18How to use a DOI?

Keywords

Schizophrenia; Interleukin-4; Polymorphism; Alleles; Genotype

Abstract

Background: Schizophrenia is a severe mental disorder characterized by disturbances in thinking, perception, emotion, and behaviour. Although the exact causes are unknown, research suggests that genetic and environmental factors contribute to its development. Besides, the interleukin-4 (IL-4) 590 C/T polymorphism comprises a variation in the DNA sequence at position 590 of the IL-4 gene. The IL-4 gene encodes interleukin-4, a cytokine involved in immune response and inflammation. This genetic polymorphism has been associated with various medical conditions, including neurological and psychiatric disorders. The relationship between IL-4 590 C/T polymorphism and schizophrenia has been previously examined.

Method: This comparative analytic research used a cross-sectional design to compare the Batak people with Schizophrenia (ODS) group and healthy control. DNA isolation and examination of Polymerase Chain Reaction – Restriction Fragment Length Polymorphism (PCR-RFLP) were performed.

Results: The Chi-Square test with Yates' correction showed no significant differences in the frequency of allele occurrence between ODS and control groups (p=0.1). Additionally, logistic regression analysis indicated a p-value of 0.415 for genotype (CC vs CT), with an odds ratio (OR) of 0.743 and a 95% confidence interval (CI) ranging from 0.364-1.517. The p-value for genotype CC vs. TT was 0.002, with an OR=0.433 and a 95% CI of 0.257-0.730.

Conclusion: This research identified a significant relationship, specifically in the TT genotype, when compared to CC

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Margreth Abletara Banurea
AU  - Mustafa M. Amin
AU  - Elmeida Effendy
PY  - 2023
DA  - 2023/12/18
TI  - Differences in Interleukin-4-590 C/T Variants Between Batak People with Schizophrenia and Healthy Control
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 121
EP  - 125
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_18
DO  - 10.2991/978-94-6463-310-8_18
ID  - Banurea2023
ER  -