Correlation Between Glutathione (GSH) Levels and Cognitive Function in People With Schizophrenia

DOI

10.2991/978-94-6463-310-8_25How to use a DOI?

Keywords

glutathione; cognitive function; schizophrenia

Abstract

Background: Cognitive impairment is a prevalent manifestation observed in people with schizophrenia and holds significant value in predicting the clinical and functional prognosis of the disease. Even though cognitive deficits are not the primary diagnostic criterion for schizophrenia, they can exacerbate the condition of patients and negatively impact their quality of life. A reduced concentration of glutathione (GSH) has been linked to this impairment in healthy individuals and numerous other neuropsychiatric conditions, such as Alzheimer’s and Parkinson’s disease. This study investigates whether a correlation exists between GSH levels and cognitive function in people with schizophrenia. It contributes to a better comprehension of the pathophysiology of schizophrenia and facilitates the development of more efficacious treatment strategies for cognitive impairment associated with this disease.

Method: This is a correlational analytic study with a cross-sectional approach, which assesses the correlation between GSH levels and cognitive function in people with schizophrenia. The sampling technique employed in this study is non-probability consecutive sampling. This method involves including all individuals who meet the predetermined selection criteria until the desired sample size is achieved. For this study, a total of 65 individuals were included, consisting of 43 males and 22 females.

Results: In this study, the male population accounted for the majority, comprising 66.15% of the total sample. The highest level of education attained by the participants was senior high school, with a prevalence of 75.38%, and the most frequently reported marital status was unmarried, at a proportion of 72.30%. Furthermore, 72.30% reported being unemployed, and regarding ethnic background, the Batak population had the highest representation, accounting for 78.46%. The median age of people with schizophrenia, PANSS, and median duration of illness was 34 years (range of 20-40 years), 65 (score range of 60-73), and four years (duration range of 2-10 years), respectively. The median GSH level in the study subjects was 9.00 μg/ml. Furthermore, there was a significant strong positive correlation (p <0.001) between GSH levels and cognitive function in people with schizophrenia. This indicated a relationship between GSH levels and MoCA-Ina scores (cognitive function).

Conclusion: This study found a correlation between GSH and cognitive function, where the two variables are directly proportional.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Riski Syahna
AU  - Elmeida Effendy
AU  - Nazli Mahdinasari Nasution
PY  - 2023
DA  - 2023/12/18
TI  - Correlation Between Glutathione (GSH) Levels and Cognitive Function in People With Schizophrenia
BT  - Proceedings of the 6th International Conference of Neuroscience, Neurology and Psychiatry Universitas Sumatera Utara (ICONAP 2023)
PB  - Atlantis Press
SP  - 166
EP  - 170
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-310-8_25
DO  - 10.2991/978-94-6463-310-8_25
ID  - Syahna2023
ER  -